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- W2104145514 abstract "Evaluation of: Rubio RM, Mora SI, Romero P, Arias CF, Lopez S. Rotavirus prevents the expression of host responses by blocking the nucleocytoplasmic transport of polyadenylated mRNAs. J. Virol. 87(11), 6336–6345 (2013). Rotaviruses are a leading cause of pediatric diarrhea worldwide and are estimated to be responsible for approximately 450,000 deaths each year. Although the incidence of severe diarrhea induced by rotavirus has fallen sharply in developed countries due to the introduction of vaccines, it remains a leading cause of diarrhea leading to death in low-income countries. A key feature of rotavirus replication is the robust production of viral proteins and simultaneous inhibition of host protein synthesis in infected cells. Studies have shown an accumulation of cytoplasmic poly(A)-binding protein (PABPC) in the nucleus of rotavirus-infected cells, but the consequences of this were unknown. Here, Rubio and colleagues show that the nuclear accumulation of PABPC inhibits the export of polyadenylated ..." @default.
- W2104145514 created "2016-06-24" @default.
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- W2104145514 date "2013-09-01" @default.
- W2104145514 modified "2023-09-27" @default.
- W2104145514 title "Sequestration strikes again: rotavirus-induced accumulation of cellular transcripts in the nucleus inhibits host protein translation" @default.
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- W2104145514 doi "https://doi.org/10.2217/fvl.13.72" @default.
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