Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104146721> ?p ?o ?g. }
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- W2104146721 abstract "G-protein-coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophage-restricted expression profile, which provide avenues for further exploration. We also review an emerging literature, which documents novel roles for GPCR signaling components in GPCR-independent signaling in macrophages. In particular, we examine the crosstalk between GPCR and TLR signaling pathways and highlight GPCR signaling molecules which are likely to have uncharacterized functions in this cell lineage." @default.
- W2104146721 created "2016-06-24" @default.
- W2104146721 creator A5006993794 @default.
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- W2104146721 creator A5026924357 @default.
- W2104146721 creator A5029662334 @default.
- W2104146721 creator A5073429131 @default.
- W2104146721 creator A5086500057 @default.
- W2104146721 date "2007-04-23" @default.
- W2104146721 modified "2023-10-16" @default.
- W2104146721 title "G-protein-coupled receptor expression, function, and signaling in macrophages" @default.
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