FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104148554> ?p ?o ?g. }

• W2104148554 endingPage "4511" @default.
• W2104148554 startingPage "4504" @default.
• W2104148554 abstract "Abstract To define specific pathways important in the multistep transformation process of normal plasma cells (PCs) to monoclonal gammopathy of uncertain significance (MGUS) and multiple myeloma (MM), we have applied microarray analysis to PCs from 5 healthy donors (N), 7 patients with MGUS, and 24 patients with newly diagnosed MM. Unsupervised hierarchical clustering using 125 genes with a large variation across all samples defined 2 groups: N and MGUS/MM. Supervised analysis identified 263 genes differentially expressed between N and MGUS and 380 genes differentially expressed between N and MM, 197 of which were also differentially regulated between N and MGUS. Only 74 genes were differentially expressed between MGUS and MM samples, indicating that the differences between MGUS and MM are smaller than those between N and MM or N and MGUS. Differentially expressed genes included oncogenes/tumor-suppressor genes (LAF4, RB1, and disabled homolog 2), cell-signaling genes (RAS family members, B-cell signaling and NF-κB genes), DNA-binding and transcription-factor genes (XBP1, zinc finger proteins, forkhead box, and ring finger proteins), and developmental genes (WNT and SHH pathways). Understanding the molecular pathogenesis of MM by gene expression profiling has demonstrated sequential genetic changes from N to malignant PCs and highlighted important pathways involved in the transformation of MGUS to MM. (Blood. 2003;102:4504-4511)" @default.
• W2104148554 created "2016-06-24" @default.
• W2104148554 creator A5006765393 @default.
• W2104148554 creator A5010021766 @default.
• W2104148554 creator A5012712111 @default.
• W2104148554 creator A5015401462 @default.
• W2104148554 creator A5016246851 @default.
• W2104148554 creator A5021405478 @default.
• W2104148554 creator A5022598327 @default.
• W2104148554 creator A5029509953 @default.
• W2104148554 creator A5031533686 @default.
• W2104148554 creator A5032464400 @default.
• W2104148554 creator A5034560778 @default.
• W2104148554 creator A5038161372 @default.
• W2104148554 creator A5039072697 @default.
• W2104148554 creator A5045740077 @default.
• W2104148554 creator A5047596320 @default.
• W2104148554 creator A5052174968 @default.
• W2104148554 creator A5055000089 @default.
• W2104148554 creator A5063099799 @default.
• W2104148554 creator A5066614617 @default.
• W2104148554 creator A5069470809 @default.
• W2104148554 creator A5072411803 @default.
• W2104148554 creator A5082564754 @default.
• W2104148554 creator A5091207345 @default.
• W2104148554 date "2003-12-15" @default.
• W2104148554 modified "2023-10-14" @default.
• W2104148554 title "Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis" @default.
• W2104148554 cites W138362336 @default.
• W2104148554 cites W1602983699 @default.
• W2104148554 cites W1672219033 @default.
• W2104148554 cites W1777794242 @default.
• W2104148554 cites W1970341138 @default.
• W2104148554 cites W1970854602 @default.
• W2104148554 cites W1976564639 @default.
• W2104148554 cites W1977707370 @default.
• W2104148554 cites W1984534203 @default.
• W2104148554 cites W1993756327 @default.
• W2104148554 cites W2025846979 @default.
• W2104148554 cites W2028150271 @default.
• W2104148554 cites W2032616537 @default.
• W2104148554 cites W2038437697 @default.
• W2104148554 cites W2102750142 @default.
• W2104148554 cites W2103114868 @default.
• W2104148554 cites W2119413986 @default.
• W2104148554 cites W2131554133 @default.
• W2104148554 cites W2144894933 @default.
• W2104148554 cites W2147246240 @default.
• W2104148554 cites W2158415042 @default.
• W2104148554 cites W2162188410 @default.
• W2104148554 cites W2331840806 @default.
• W2104148554 cites W3143387670 @default.
• W2104148554 doi "https://doi.org/10.1182/blood-2003-01-0016" @default.
• W2104148554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12947006" @default.
• W2104148554 hasPublicationYear "2003" @default.
• W2104148554 type Work @default.
• W2104148554 sameAs 2104148554 @default.
• W2104148554 citedByCount "226" @default.
• W2104148554 countsByYear W21041485542012 @default.
• W2104148554 countsByYear W21041485542013 @default.
• W2104148554 countsByYear W21041485542014 @default.
• W2104148554 countsByYear W21041485542015 @default.
• W2104148554 countsByYear W21041485542016 @default.
• W2104148554 countsByYear W21041485542017 @default.
• W2104148554 countsByYear W21041485542018 @default.
• W2104148554 countsByYear W21041485542019 @default.
• W2104148554 countsByYear W21041485542020 @default.
• W2104148554 countsByYear W21041485542021 @default.
• W2104148554 countsByYear W21041485542022 @default.
• W2104148554 countsByYear W21041485542023 @default.
• W2104148554 crossrefType "journal-article" @default.
• W2104148554 hasAuthorship W2104148554A5006765393 @default.
• W2104148554 hasAuthorship W2104148554A5010021766 @default.
• W2104148554 hasAuthorship W2104148554A5012712111 @default.
• W2104148554 hasAuthorship W2104148554A5015401462 @default.
• W2104148554 hasAuthorship W2104148554A5016246851 @default.
• W2104148554 hasAuthorship W2104148554A5021405478 @default.
• W2104148554 hasAuthorship W2104148554A5022598327 @default.
• W2104148554 hasAuthorship W2104148554A5029509953 @default.
• W2104148554 hasAuthorship W2104148554A5031533686 @default.
• W2104148554 hasAuthorship W2104148554A5032464400 @default.
• W2104148554 hasAuthorship W2104148554A5034560778 @default.
• W2104148554 hasAuthorship W2104148554A5038161372 @default.
• W2104148554 hasAuthorship W2104148554A5039072697 @default.
• W2104148554 hasAuthorship W2104148554A5045740077 @default.
• W2104148554 hasAuthorship W2104148554A5047596320 @default.
• W2104148554 hasAuthorship W2104148554A5052174968 @default.
• W2104148554 hasAuthorship W2104148554A5055000089 @default.
• W2104148554 hasAuthorship W2104148554A5063099799 @default.
• W2104148554 hasAuthorship W2104148554A5066614617 @default.
• W2104148554 hasAuthorship W2104148554A5069470809 @default.
• W2104148554 hasAuthorship W2104148554A5072411803 @default.
• W2104148554 hasAuthorship W2104148554A5082564754 @default.
• W2104148554 hasAuthorship W2104148554A5091207345 @default.
• W2104148554 hasBestOaLocation W21041485541 @default.
• W2104148554 hasConcept C104317684 @default.
• W2104148554 hasConcept C137620995 @default.
• W2104148554 hasConcept C150194340 @default.

• next