FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104156244> ?p ?o ?g. }

• W2104156244 endingPage "35" @default.
• W2104156244 startingPage "1327" @default.
• W2104156244 abstract "Mesothelin, a cell surface glycoprotein, is an attractive candidate for targeted therapy given its overexpression, as detected by immunohistochemistry, in mesotheliomas. The goal of this study was to evaluate mesothelin expression in fresh tumor cells obtained from ascites of patients with peritoneal mesothelioma, as well as to determine the sensitivity of these cells to an immunotoxin targeting mesothelin.Tumor cells were evaluated for mesothelin expression by flow cytometry using the murine anti-mesothelin monoclonal antibody K1. The sensitivity of these tumor cells to SS1(dsFv)PE38, an immunotoxin consisting of the anti-mesothelin Fv linked to a mutated Pseudomonas exotoxin, was evaluated using a cell proliferation assay.Of the 7 tumor cell lines established from ascites of 12 patients with peritoneal mesothelioma, 6 expressed mesothelin while one cell line did not. Cell lines that expressed mesothelin were very sensitive to SS1(dsFv)PE38 with IC50s ranging between 0.08-3.9 ng/ml, while the cell line that was mesothelin-negative was resistant to SS1(dsFv)PE38.High expression of mesothelin is seen on tumor cells of patients with peritoneal mesothelioma and correlates with sensitivity to SS1(dsFv)PE38. Clinical studies of SS1(dsFv)PE38 in patients with peritoneal mesotheliomas are ongoing." @default.
• W2104156244 created "2016-06-24" @default.
• W2104156244 creator A5029872582 @default.
• W2104156244 creator A5063990130 @default.
• W2104156244 creator A5077168338 @default.
• W2104156244 creator A5077968671 @default.
• W2104156244 date "2004-07-28" @default.
• W2104156244 modified "2023-09-23" @default.
• W2104156244 title "Cytotoxic activity of the recombinant anti-mesothelin immunotoxin, SS1(dsFv)PE38, towards tumor cell lines established from ascites of patients with peritoneal mesotheliomas." @default.
• W2104156244 cites W1607832269 @default.
• W2104156244 cites W1927730613 @default.
• W2104156244 cites W1930738953 @default.
• W2104156244 cites W1968231240 @default.
• W2104156244 cites W1968564858 @default.
• W2104156244 cites W1973926629 @default.
• W2104156244 cites W1974247505 @default.
• W2104156244 cites W1977122810 @default.
• W2104156244 cites W1978653793 @default.
• W2104156244 cites W1979568379 @default.
• W2104156244 cites W1981411649 @default.
• W2104156244 cites W1985613060 @default.
• W2104156244 cites W2015783493 @default.
• W2104156244 cites W2020402295 @default.
• W2104156244 cites W2024423737 @default.
• W2104156244 cites W2031243108 @default.
• W2104156244 cites W2040500107 @default.
• W2104156244 cites W2050658031 @default.
• W2104156244 cites W2120353092 @default.
• W2104156244 cites W2137479474 @default.
• W2104156244 cites W2171923478 @default.
• W2104156244 cites W2172175430 @default.
• W2104156244 cites W2257197146 @default.
• W2104156244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15274292" @default.
• W2104156244 hasPublicationYear "2004" @default.
• W2104156244 type Work @default.
• W2104156244 sameAs 2104156244 @default.
• W2104156244 citedByCount "14" @default.
• W2104156244 countsByYear W21041562442014 @default.
• W2104156244 countsByYear W21041562442016 @default.
• W2104156244 countsByYear W21041562442017 @default.
• W2104156244 countsByYear W21041562442018 @default.
• W2104156244 countsByYear W21041562442019 @default.
• W2104156244 countsByYear W21041562442020 @default.
• W2104156244 countsByYear W21041562442021 @default.
• W2104156244 countsByYear W21041562442022 @default.
• W2104156244 countsByYear W21041562442023 @default.
• W2104156244 crossrefType "journal-article" @default.
• W2104156244 hasAuthorship W2104156244A5029872582 @default.
• W2104156244 hasAuthorship W2104156244A5063990130 @default.
• W2104156244 hasAuthorship W2104156244A5077168338 @default.
• W2104156244 hasAuthorship W2104156244A5077968671 @default.
• W2104156244 hasConcept C109316439 @default.
• W2104156244 hasConcept C115085202 @default.
• W2104156244 hasConcept C142724271 @default.
• W2104156244 hasConcept C153911025 @default.
• W2104156244 hasConcept C159654299 @default.
• W2104156244 hasConcept C182179738 @default.
• W2104156244 hasConcept C202751555 @default.
• W2104156244 hasConcept C203014093 @default.
• W2104156244 hasConcept C204232928 @default.
• W2104156244 hasConcept C2777045440 @default.
• W2104156244 hasConcept C2777407522 @default.
• W2104156244 hasConcept C502942594 @default.
• W2104156244 hasConcept C542903549 @default.
• W2104156244 hasConcept C54355233 @default.
• W2104156244 hasConcept C55493867 @default.
• W2104156244 hasConcept C71924100 @default.
• W2104156244 hasConcept C81885089 @default.
• W2104156244 hasConcept C86803240 @default.
• W2104156244 hasConceptScore W2104156244C109316439 @default.
• W2104156244 hasConceptScore W2104156244C115085202 @default.
• W2104156244 hasConceptScore W2104156244C142724271 @default.
• W2104156244 hasConceptScore W2104156244C153911025 @default.
• W2104156244 hasConceptScore W2104156244C159654299 @default.
• W2104156244 hasConceptScore W2104156244C182179738 @default.
• W2104156244 hasConceptScore W2104156244C202751555 @default.
• W2104156244 hasConceptScore W2104156244C203014093 @default.
• W2104156244 hasConceptScore W2104156244C204232928 @default.
• W2104156244 hasConceptScore W2104156244C2777045440 @default.
• W2104156244 hasConceptScore W2104156244C2777407522 @default.
• W2104156244 hasConceptScore W2104156244C502942594 @default.
• W2104156244 hasConceptScore W2104156244C542903549 @default.
• W2104156244 hasConceptScore W2104156244C54355233 @default.
• W2104156244 hasConceptScore W2104156244C55493867 @default.
• W2104156244 hasConceptScore W2104156244C71924100 @default.
• W2104156244 hasConceptScore W2104156244C81885089 @default.
• W2104156244 hasConceptScore W2104156244C86803240 @default.
• W2104156244 hasIssue "3a" @default.
• W2104156244 hasLocation W21041562441 @default.
• W2104156244 hasOpenAccess W2104156244 @default.
• W2104156244 hasPrimaryLocation W21041562441 @default.
• W2104156244 hasRelatedWork W138135214 @default.
• W2104156244 hasRelatedWork W1505618476 @default.
• W2104156244 hasRelatedWork W1968564858 @default.
• W2104156244 hasRelatedWork W1977122810 @default.
• W2104156244 hasRelatedWork W1978653793 @default.
• W2104156244 hasRelatedWork W1979568379 @default.
• W2104156244 hasRelatedWork W1985613060 @default.

• next