FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104175890> ?p ?o ?g. }

• W2104175890 endingPage "1194" @default.
• W2104175890 startingPage "1185" @default.
• W2104175890 abstract "Success in cartilage and fibrocartilage tissue engineering relies heavily on using an appropriate cell source. Many different cell sources have been identified, including primary and stem cells, along with experimental strategies to obtain the required number of cells or to induce chondrogenesis. However, no definitive method exists to quantitatively evaluate the similarity of the resulting cell phenotypes to those of the native cells between candidate strategies. In this study, we develop an integrative approach to enable such evaluations by deriving, from gene expression profiles, two quantitative metrics representing the nearest location within the range of native cell phenotypes and the deviation from it. As an example application to evaluating potential cell sources for cartilage or meniscus tissue engineering, we examine phenotypic changes of juvenile and adult articular chondrocytes and fibrochondrocytes across multiple passages and subsequent 3D culture. A substantial change was observed in cell phenotype due to the isolation process itself, followed by a clear progression toward the outer meniscal cell phenotype with passage. The new metrics also indicated that 3D culture moderately reduced the passage-induced deviation from the native meniscal phenotypes for juvenile chondrocytes and adult fibrochondrocytes, which was not obvious through examination of individual gene expressions. However, brief 3D culture alone did not move any of the cells towards an inner meniscal phenotype, the most relevant target for meniscal tissue engineering. This integrative approach of examining and combining multiple gene expressions can be used to evaluate various other tissue-engineering strategies to direct cells toward the desired phenotype. Copyright © 2015 John Wiley & Sons, Ltd." @default.
• W2104175890 created "2016-06-24" @default.
• W2104175890 creator A5044469698 @default.
• W2104175890 creator A5087909997 @default.
• W2104175890 date "2015-03-30" @default.
• W2104175890 modified "2023-10-18" @default.
• W2104175890 title "Quantitative tracking of passage and 3D culture effects on chondrocyte and fibrochondrocyte gene expression" @default.
• W2104175890 cites W1972766239 @default.
• W2104175890 cites W1974384763 @default.
• W2104175890 cites W1975358041 @default.
• W2104175890 cites W1995798248 @default.
• W2104175890 cites W1995944358 @default.
• W2104175890 cites W2018982288 @default.
• W2104175890 cites W2021311978 @default.
• W2104175890 cites W2022482745 @default.
• W2104175890 cites W2023724309 @default.
• W2104175890 cites W2032691826 @default.
• W2104175890 cites W2046125987 @default.
• W2104175890 cites W2050273631 @default.
• W2104175890 cites W2056292590 @default.
• W2104175890 cites W2060813229 @default.
• W2104175890 cites W2066581346 @default.
• W2104175890 cites W2066799169 @default.
• W2104175890 cites W2072418008 @default.
• W2104175890 cites W2075713519 @default.
• W2104175890 cites W2075899672 @default.
• W2104175890 cites W2078003030 @default.
• W2104175890 cites W2088824573 @default.
• W2104175890 cites W2089567262 @default.
• W2104175890 cites W2091464294 @default.
• W2104175890 cites W2106498077 @default.
• W2104175890 cites W2107826597 @default.
• W2104175890 cites W2110792647 @default.
• W2104175890 cites W2112275933 @default.
• W2104175890 cites W2120660648 @default.
• W2104175890 cites W2124094899 @default.
• W2104175890 cites W2130513695 @default.
• W2104175890 cites W2133915381 @default.
• W2104175890 cites W2146560938 @default.
• W2104175890 cites W2149548143 @default.
• W2104175890 cites W2158640783 @default.
• W2104175890 cites W2159315880 @default.
• W2104175890 cites W2159624824 @default.
• W2104175890 cites W2161293654 @default.
• W2104175890 cites W2163656957 @default.
• W2104175890 cites W2164933897 @default.
• W2104175890 cites W2165730847 @default.
• W2104175890 cites W2166392134 @default.
• W2104175890 cites W2170405507 @default.
• W2104175890 cites W4365786940 @default.
• W2104175890 doi "https://doi.org/10.1002/term.2022" @default.
• W2104175890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25824488" @default.
• W2104175890 hasPublicationYear "2015" @default.
• W2104175890 type Work @default.
• W2104175890 sameAs 2104175890 @default.
• W2104175890 citedByCount "11" @default.
• W2104175890 countsByYear W21041758902017 @default.
• W2104175890 countsByYear W21041758902019 @default.
• W2104175890 countsByYear W21041758902020 @default.
• W2104175890 countsByYear W21041758902021 @default.
• W2104175890 countsByYear W21041758902022 @default.
• W2104175890 crossrefType "journal-article" @default.
• W2104175890 hasAuthorship W2104175890A5044469698 @default.
• W2104175890 hasAuthorship W2104175890A5087909997 @default.
• W2104175890 hasBestOaLocation W21041758901 @default.
• W2104175890 hasConcept C104317684 @default.
• W2104175890 hasConcept C105702510 @default.
• W2104175890 hasConcept C127716648 @default.
• W2104175890 hasConcept C142724271 @default.
• W2104175890 hasConcept C1491633281 @default.
• W2104175890 hasConcept C150194340 @default.
• W2104175890 hasConcept C201750760 @default.
• W2104175890 hasConcept C204787440 @default.
• W2104175890 hasConcept C2776164576 @default.
• W2104175890 hasConcept C2780550940 @default.
• W2104175890 hasConcept C2781218938 @default.
• W2104175890 hasConcept C2781403057 @default.
• W2104175890 hasConcept C28328180 @default.
• W2104175890 hasConcept C3020332539 @default.
• W2104175890 hasConcept C35496256 @default.
• W2104175890 hasConcept C49892992 @default.
• W2104175890 hasConcept C54355233 @default.
• W2104175890 hasConcept C60644358 @default.
• W2104175890 hasConcept C70721500 @default.
• W2104175890 hasConcept C71924100 @default.
• W2104175890 hasConcept C86803240 @default.
• W2104175890 hasConcept C95444343 @default.
• W2104175890 hasConceptScore W2104175890C104317684 @default.
• W2104175890 hasConceptScore W2104175890C105702510 @default.
• W2104175890 hasConceptScore W2104175890C127716648 @default.
• W2104175890 hasConceptScore W2104175890C142724271 @default.
• W2104175890 hasConceptScore W2104175890C1491633281 @default.
• W2104175890 hasConceptScore W2104175890C150194340 @default.
• W2104175890 hasConceptScore W2104175890C201750760 @default.
• W2104175890 hasConceptScore W2104175890C204787440 @default.
• W2104175890 hasConceptScore W2104175890C2776164576 @default.
• W2104175890 hasConceptScore W2104175890C2780550940 @default.
• W2104175890 hasConceptScore W2104175890C2781218938 @default.

• next