Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104189327> ?p ?o ?g. }
- W2104189327 endingPage "376" @default.
- W2104189327 startingPage "364" @default.
- W2104189327 abstract "Synaptosomal-associated protein of 25 kDa (SNAP-25) is a protein that participates in the regulation of synaptic vesicle exocytosis through the formation of the soluble NSF attachment protein receptor complex and modulates voltage-gated calcium channels activity. The Snap25 gene has been associated with schizophrenia, attention deficit hyperactivity disorder, and bipolar disorder, and lower levels of SNAP-25 have been described in patients with schizophrenia. We used SNAP-25 heterozygous (SNAP-25+/−) mice to investigate at which extent the reduction of the protein levels affects neuronal network function and mouse behavior. As interactions of genotype with the specific laboratory conditions may impact behavioral results, the study was performed through a multilaboratory study in which behavioral tests were replicated in at least 2 of 3 distinct European laboratories. Reductions of SNAP-25 levels were associated with a moderate hyperactivity, which disappeared in the adult animals, and with impaired associative learning and memory. Electroencephalographic recordings revealed the occurrence of frequent spikes, suggesting a diffuse network hyperexcitability. Consistently, SNAP-25+/− mice displayed higher susceptibility to kainate-induced seizures, paralleled by degeneration of hilar neurons. Notably, both EEG profile and cognitive defects were improved by antiepileptic drugs. These results indicate that reduction of SNAP-25 expression is associated to generation of epileptiform discharges and cognitive dysfunctions, which can be effectively treated by antiepileptic drugs." @default.
- W2104189327 created "2016-06-24" @default.
- W2104189327 creator A5001173474 @default.
- W2104189327 creator A5018627313 @default.
- W2104189327 creator A5020726968 @default.
- W2104189327 creator A5024982893 @default.
- W2104189327 creator A5026047312 @default.
- W2104189327 creator A5026909491 @default.
- W2104189327 creator A5031850482 @default.
- W2104189327 creator A5033851375 @default.
- W2104189327 creator A5043383746 @default.
- W2104189327 creator A5044072597 @default.
- W2104189327 creator A5046067488 @default.
- W2104189327 creator A5048757910 @default.
- W2104189327 creator A5053529456 @default.
- W2104189327 creator A5057267397 @default.
- W2104189327 creator A5061203019 @default.
- W2104189327 creator A5067906768 @default.
- W2104189327 creator A5071583353 @default.
- W2104189327 creator A5075243399 @default.
- W2104189327 creator A5078226279 @default.
- W2104189327 date "2012-10-12" @default.
- W2104189327 modified "2023-09-26" @default.
- W2104189327 title "Epileptiform Activity and Cognitive Deficits in SNAP-25+/− Mice are Normalized by Antiepileptic Drugs" @default.
- W2104189327 cites W1504011172 @default.
- W2104189327 cites W1510573798 @default.
- W2104189327 cites W1607993356 @default.
- W2104189327 cites W16434660 @default.
- W2104189327 cites W1908021040 @default.
- W2104189327 cites W1963940970 @default.
- W2104189327 cites W1964284466 @default.
- W2104189327 cites W1971248623 @default.
- W2104189327 cites W1983776358 @default.
- W2104189327 cites W1985941787 @default.
- W2104189327 cites W1986716625 @default.
- W2104189327 cites W1988494159 @default.
- W2104189327 cites W1990402607 @default.
- W2104189327 cites W1991176458 @default.
- W2104189327 cites W1992398467 @default.
- W2104189327 cites W1993706808 @default.
- W2104189327 cites W1994475466 @default.
- W2104189327 cites W1997576450 @default.
- W2104189327 cites W2000302106 @default.
- W2104189327 cites W2006231837 @default.
- W2104189327 cites W2006878605 @default.
- W2104189327 cites W2010604180 @default.
- W2104189327 cites W2013179658 @default.
- W2104189327 cites W2014632617 @default.
- W2104189327 cites W2024136850 @default.
- W2104189327 cites W2024394768 @default.
- W2104189327 cites W2025025319 @default.
- W2104189327 cites W2037306742 @default.
- W2104189327 cites W2037841295 @default.
- W2104189327 cites W2039414366 @default.
- W2104189327 cites W2042773138 @default.
- W2104189327 cites W2043564893 @default.
- W2104189327 cites W2046491231 @default.
- W2104189327 cites W2049521887 @default.
- W2104189327 cites W2049899548 @default.
- W2104189327 cites W2050866329 @default.
- W2104189327 cites W2055354419 @default.
- W2104189327 cites W2057930204 @default.
- W2104189327 cites W2065803582 @default.
- W2104189327 cites W2067228399 @default.
- W2104189327 cites W2068022080 @default.
- W2104189327 cites W2071869790 @default.
- W2104189327 cites W2073212758 @default.
- W2104189327 cites W2076353341 @default.
- W2104189327 cites W2077451533 @default.
- W2104189327 cites W2079651792 @default.
- W2104189327 cites W2082547139 @default.
- W2104189327 cites W2083480808 @default.
- W2104189327 cites W2084641129 @default.
- W2104189327 cites W2088077925 @default.
- W2104189327 cites W2093763836 @default.
- W2104189327 cites W2098980568 @default.
- W2104189327 cites W2100727635 @default.
- W2104189327 cites W2106036700 @default.
- W2104189327 cites W2107569547 @default.
- W2104189327 cites W2107973794 @default.
- W2104189327 cites W2141896877 @default.
- W2104189327 cites W2144638913 @default.
- W2104189327 cites W2144963822 @default.
- W2104189327 cites W2147024435 @default.
- W2104189327 cites W2150936467 @default.
- W2104189327 cites W2166164585 @default.
- W2104189327 cites W4231211787 @default.
- W2104189327 cites W4247283871 @default.
- W2104189327 doi "https://doi.org/10.1093/cercor/bhs316" @default.
- W2104189327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23064108" @default.
- W2104189327 hasPublicationYear "2012" @default.
- W2104189327 type Work @default.
- W2104189327 sameAs 2104189327 @default.
- W2104189327 citedByCount "75" @default.
- W2104189327 countsByYear W21041893272013 @default.
- W2104189327 countsByYear W21041893272014 @default.
- W2104189327 countsByYear W21041893272015 @default.
- W2104189327 countsByYear W21041893272016 @default.