FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104208472> ?p ?o ?g. }

• W2104208472 endingPage "H1077" @default.
• W2104208472 startingPage "H1065" @default.
• W2104208472 abstract "Lymphedema, a common complication of cancer treatment, is characterized by inflammation, fibrosis, and adipose deposition. We have previously shown that macrophage infiltration is increased in mouse models of lymphedema. Because macrophages are regulators of lymphangiogenesis and fibrosis, this study aimed to determine the role of these cells in lymphedema using depletion experiments. Matched biopsy specimens of normal and lymphedema tissues were obtained from patients with unilateral upper extremity breast cancer-related lymphedema, and macrophage accumulation was assessed using immunohistochemistry. In addition, we used a mouse tail model of lymphedema to quantify macrophage accumulation and analyze outcomes of conditional macrophage depletion. Histological analysis of clinical lymphedema biopsies revealed significantly increased macrophage infiltration. Similarly, in the mouse tail model, lymphatic injury increased the number of macrophages and favored M2 differentiation. Chronic macrophage depletion using lethally irradiated wild-type mice reconstituted with CD11b-diphtheria toxin receptor mouse bone marrow did not decrease swelling, adipose deposition, or overall inflammation. Macrophage depletion after lymphedema had become established significantly increased fibrosis and accumulation of CD4 + cells and promoted Th2 differentiation while decreasing lymphatic transport capacity and VEGF-C expression. Our findings suggest that macrophages home to lymphedematous tissues and differentiate into the M2 phenotype. In addition, our findings suggest that macrophages have an antifibrotic role in lymphedema and either directly or indirectly regulate CD4 + cell accumulation and Th2 differentiation. Finally, our findings suggest that lymphedema-associated macrophages are a major source of VEGF-C and that impaired macrophage responses after lymphatic injury result in decreased lymphatic function." @default.
• W2104208472 created "2016-06-24" @default.
• W2104208472 creator A5004145046 @default.
• W2104208472 creator A5006440828 @default.
• W2104208472 creator A5012628757 @default.
• W2104208472 creator A5022550254 @default.
• W2104208472 creator A5028140941 @default.
• W2104208472 creator A5031905804 @default.
• W2104208472 creator A5056592192 @default.
• W2104208472 creator A5075554512 @default.
• W2104208472 creator A5081956660 @default.
• W2104208472 creator A5084770412 @default.
• W2104208472 date "2015-05-01" @default.
• W2104208472 modified "2023-10-11" @default.
• W2104208472 title "Regulation of inflammation and fibrosis by macrophages in lymphedema" @default.
• W2104208472 cites W1919985275 @default.
• W2104208472 cites W1967292619 @default.
• W2104208472 cites W1968920262 @default.
• W2104208472 cites W1977540662 @default.
• W2104208472 cites W1980485314 @default.
• W2104208472 cites W1981269419 @default.
• W2104208472 cites W1984495906 @default.
• W2104208472 cites W1985859986 @default.
• W2104208472 cites W1987387144 @default.
• W2104208472 cites W1993570315 @default.
• W2104208472 cites W1993677761 @default.
• W2104208472 cites W1995299599 @default.
• W2104208472 cites W1997811287 @default.
• W2104208472 cites W2004424104 @default.
• W2104208472 cites W2008214282 @default.
• W2104208472 cites W2010156941 @default.
• W2104208472 cites W2017390700 @default.
• W2104208472 cites W2017821597 @default.
• W2104208472 cites W2027065592 @default.
• W2104208472 cites W2032639324 @default.
• W2104208472 cites W2038307590 @default.
• W2104208472 cites W2056884670 @default.
• W2104208472 cites W2102471792 @default.
• W2104208472 cites W2103863906 @default.
• W2104208472 cites W2105448220 @default.
• W2104208472 cites W2110862517 @default.
• W2104208472 cites W2114064598 @default.
• W2104208472 cites W2114570899 @default.
• W2104208472 cites W2120970035 @default.
• W2104208472 cites W2122156463 @default.
• W2104208472 cites W2124966064 @default.
• W2104208472 cites W2131585324 @default.
• W2104208472 cites W2134629206 @default.
• W2104208472 cites W2144032315 @default.
• W2104208472 cites W2146553975 @default.
• W2104208472 cites W2151311370 @default.
• W2104208472 cites W2165334726 @default.
• W2104208472 cites W2169491358 @default.
• W2104208472 cites W4250007760 @default.
• W2104208472 doi "https://doi.org/10.1152/ajpheart.00598.2014" @default.
• W2104208472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4551121" @default.
• W2104208472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25724493" @default.
• W2104208472 hasPublicationYear "2015" @default.
• W2104208472 type Work @default.
• W2104208472 sameAs 2104208472 @default.
• W2104208472 citedByCount "107" @default.
• W2104208472 countsByYear W21042084722016 @default.
• W2104208472 countsByYear W21042084722017 @default.
• W2104208472 countsByYear W21042084722018 @default.
• W2104208472 countsByYear W21042084722019 @default.
• W2104208472 countsByYear W21042084722020 @default.
• W2104208472 countsByYear W21042084722021 @default.
• W2104208472 countsByYear W21042084722022 @default.
• W2104208472 countsByYear W21042084722023 @default.
• W2104208472 crossrefType "journal-article" @default.
• W2104208472 hasAuthorship W2104208472A5004145046 @default.
• W2104208472 hasAuthorship W2104208472A5006440828 @default.
• W2104208472 hasAuthorship W2104208472A5012628757 @default.
• W2104208472 hasAuthorship W2104208472A5022550254 @default.
• W2104208472 hasAuthorship W2104208472A5028140941 @default.
• W2104208472 hasAuthorship W2104208472A5031905804 @default.
• W2104208472 hasAuthorship W2104208472A5056592192 @default.
• W2104208472 hasAuthorship W2104208472A5075554512 @default.
• W2104208472 hasAuthorship W2104208472A5081956660 @default.
• W2104208472 hasAuthorship W2104208472A5084770412 @default.
• W2104208472 hasBestOaLocation W21042084722 @default.
• W2104208472 hasConcept C121608353 @default.
• W2104208472 hasConcept C126322002 @default.
• W2104208472 hasConcept C142724271 @default.
• W2104208472 hasConcept C170493617 @default.
• W2104208472 hasConcept C171089720 @default.
• W2104208472 hasConcept C171779818 @default.
• W2104208472 hasConcept C181152851 @default.
• W2104208472 hasConcept C202751555 @default.
• W2104208472 hasConcept C203014093 @default.
• W2104208472 hasConcept C2776636583 @default.
• W2104208472 hasConcept C2776914184 @default.
• W2104208472 hasConcept C2779013556 @default.
• W2104208472 hasConcept C2779244956 @default.
• W2104208472 hasConcept C2780559512 @default.
• W2104208472 hasConcept C2781392513 @default.
• W2104208472 hasConcept C502942594 @default.
• W2104208472 hasConcept C530470458 @default.

• next