Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104208882> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2104208882 endingPage "A8" @default.
- W2104208882 startingPage "A8" @default.
- W2104208882 abstract "Absolute risk assessment (ARA) is promoted for guiding osteoporosis treatment decisions. Competing guidelines lack clarity on how to incorporate ARA into practice. We compared 6 strategies to identify one that minimized cost and optimized quality-adjusted life years (QALYs) in United States (US) veterans. We developed a Markov model comparing 6 strategies in elderly male veterans including (1) ARA alone, (2) ARA in concert with BMD screening, (3) BMD screening alone, (4) waiting for fracture, (5) doing nothing, and (6) an approximation of current care, which included a combination of strategies 2-5. Health states included community, nursing-home, and death. Three models with different assumptions concerning treatment efficacy among high-risk versus osteoporotic patients were developed: equivalent, reduced, and lacking. The time horizon and perspectives were 30-years and the Veterans Health Administration (VHA). Parameter estimates were derived from the literature and analyses of VHA data. First- and second-order Monte-Carlo simulations were conducted 10,000 and 1,000 times, respectively. The total costs incurred under the assumption of equivalent efficacy ranged from $86,049 for ARA alone to $88,360 for BMD screening alone. The total QALYs realized ranged from 10.87 for doing nothing to 10.90 for ARA alone. Compared to the current standard, the incremental cost-effectiveness ratio (ICER) for BMD screening alone was $34,833/QALY, but ARA alone dominated all strategies. Results were similar but less pronounced for the alternative assumption of reduced efficacy for treatment in high-risk patients. The third assumption of non-efficacy in high-risk patients produced an ICER of $154,367/QALY for BMD screening alone compared to ARA alone, which dominated all other strategies. ARA may represent an important tool for minimizing cost and optimizing fracture prevention outcomes in US veterans." @default.
- W2104208882 created "2016-06-24" @default.
- W2104208882 creator A5002607014 @default.
- W2104208882 creator A5015150405 @default.
- W2104208882 creator A5025015223 @default.
- W2104208882 creator A5058217274 @default.
- W2104208882 creator A5061171892 @default.
- W2104208882 creator A5066281483 @default.
- W2104208882 creator A5069032571 @default.
- W2104208882 date "2012-06-01" @default.
- W2104208882 modified "2023-09-27" @default.
- W2104208882 title "MO3 Cost-Effectiveness Analysis of Different Strategies for Fragility Fracture Prevention in United States Male Veterans" @default.
- W2104208882 doi "https://doi.org/10.1016/j.jval.2012.03.1380" @default.
- W2104208882 hasPublicationYear "2012" @default.
- W2104208882 type Work @default.
- W2104208882 sameAs 2104208882 @default.
- W2104208882 citedByCount "2" @default.
- W2104208882 countsByYear W21042088822014 @default.
- W2104208882 countsByYear W21042088822015 @default.
- W2104208882 crossrefType "journal-article" @default.
- W2104208882 hasAuthorship W2104208882A5002607014 @default.
- W2104208882 hasAuthorship W2104208882A5015150405 @default.
- W2104208882 hasAuthorship W2104208882A5025015223 @default.
- W2104208882 hasAuthorship W2104208882A5058217274 @default.
- W2104208882 hasAuthorship W2104208882A5061171892 @default.
- W2104208882 hasAuthorship W2104208882A5066281483 @default.
- W2104208882 hasAuthorship W2104208882A5069032571 @default.
- W2104208882 hasBestOaLocation W21042088821 @default.
- W2104208882 hasConcept C112930515 @default.
- W2104208882 hasConcept C126322002 @default.
- W2104208882 hasConcept C160735492 @default.
- W2104208882 hasConcept C162324750 @default.
- W2104208882 hasConcept C2776541429 @default.
- W2104208882 hasConcept C3019080777 @default.
- W2104208882 hasConcept C50522688 @default.
- W2104208882 hasConcept C64332521 @default.
- W2104208882 hasConcept C71924100 @default.
- W2104208882 hasConcept C74909509 @default.
- W2104208882 hasConceptScore W2104208882C112930515 @default.
- W2104208882 hasConceptScore W2104208882C126322002 @default.
- W2104208882 hasConceptScore W2104208882C160735492 @default.
- W2104208882 hasConceptScore W2104208882C162324750 @default.
- W2104208882 hasConceptScore W2104208882C2776541429 @default.
- W2104208882 hasConceptScore W2104208882C3019080777 @default.
- W2104208882 hasConceptScore W2104208882C50522688 @default.
- W2104208882 hasConceptScore W2104208882C64332521 @default.
- W2104208882 hasConceptScore W2104208882C71924100 @default.
- W2104208882 hasConceptScore W2104208882C74909509 @default.
- W2104208882 hasIssue "4" @default.
- W2104208882 hasLocation W21042088821 @default.
- W2104208882 hasOpenAccess W2104208882 @default.
- W2104208882 hasPrimaryLocation W21042088821 @default.
- W2104208882 hasRelatedWork W1964369540 @default.
- W2104208882 hasRelatedWork W1977122543 @default.
- W2104208882 hasRelatedWork W1988580400 @default.
- W2104208882 hasRelatedWork W2001074839 @default.
- W2104208882 hasRelatedWork W2008127256 @default.
- W2104208882 hasRelatedWork W2078207681 @default.
- W2104208882 hasRelatedWork W2109316890 @default.
- W2104208882 hasRelatedWork W2137091400 @default.
- W2104208882 hasRelatedWork W2527914130 @default.
- W2104208882 hasRelatedWork W2976142964 @default.
- W2104208882 hasVolume "15" @default.
- W2104208882 isParatext "false" @default.
- W2104208882 isRetracted "false" @default.
- W2104208882 magId "2104208882" @default.
- W2104208882 workType "article" @default.