Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104242553> ?p ?o ?g. }
- W2104242553 endingPage "2199" @default.
- W2104242553 startingPage "2189" @default.
- W2104242553 abstract "Bryostatin 1 (bryo 1) is an example of a novel class of anticancer drug which modulates protein kinase C (PKC) activity. It has varied biological effects mediated largely by the initial activation of PKC, followed by its rapid downregulation. Bryo 1 stimulates in vitro and in vivo haematopoietic progenitor cell growth in a concentration-dependent and lineage-specific fashion. Granulocytes, lymphocytes, monocytes and platelets are all functionally stimulated by bryo 1. Stimulation of cytotoxic T-cell activity by bryo 1 has led to research utilising bryo 1 as an immunotherapeutic agent in mouse tumour xenograft models. The clinical development of bryo 1 followed the demonstration of direct in vitro activity against various tumour cell lines. Multiple Phase I trials have shown muscle pain and flu-like symptoms are the most common toxicities associated with administration of bryo 1. There is particular interest in the role of bryo 1 in haematologic malignancies because of its capacity to induce leukaemic cell differentiation. There is ample in vitro data demonstrating that bryo 1 can sensitise tumour cells to cytotoxic agents. Recent clinical work has focused on combining bryo 1 with traditional chemotherapeutic agents for both haematologic and non-haematologic cancers." @default.
- W2104242553 created "2016-06-24" @default.
- W2104242553 creator A5011817630 @default.
- W2104242553 creator A5034791164 @default.
- W2104242553 date "1999-12-01" @default.
- W2104242553 modified "2023-09-26" @default.
- W2104242553 title "Pharmacology and clinical experience with bryostatin 1: a novel anticancer drug" @default.
- W2104242553 cites W145541864 @default.
- W2104242553 cites W1483045044 @default.
- W2104242553 cites W1587135257 @default.
- W2104242553 cites W1963523580 @default.
- W2104242553 cites W1968162244 @default.
- W2104242553 cites W1968423730 @default.
- W2104242553 cites W1976882802 @default.
- W2104242553 cites W1981880855 @default.
- W2104242553 cites W1982463781 @default.
- W2104242553 cites W1986461153 @default.
- W2104242553 cites W1987357686 @default.
- W2104242553 cites W1988083861 @default.
- W2104242553 cites W1989859193 @default.
- W2104242553 cites W199170431 @default.
- W2104242553 cites W1992555764 @default.
- W2104242553 cites W2001692359 @default.
- W2104242553 cites W2004308413 @default.
- W2104242553 cites W2007069751 @default.
- W2104242553 cites W2007728522 @default.
- W2104242553 cites W2029212302 @default.
- W2104242553 cites W2032878233 @default.
- W2104242553 cites W2036512276 @default.
- W2104242553 cites W2036693363 @default.
- W2104242553 cites W2038905259 @default.
- W2104242553 cites W2041795317 @default.
- W2104242553 cites W2044457708 @default.
- W2104242553 cites W2051976901 @default.
- W2104242553 cites W2052071780 @default.
- W2104242553 cites W2054347409 @default.
- W2104242553 cites W2060969354 @default.
- W2104242553 cites W2064541977 @default.
- W2104242553 cites W2065330483 @default.
- W2104242553 cites W2069723308 @default.
- W2104242553 cites W2069873423 @default.
- W2104242553 cites W2071813864 @default.
- W2104242553 cites W2072628162 @default.
- W2104242553 cites W2076297327 @default.
- W2104242553 cites W2108500002 @default.
- W2104242553 cites W2115941302 @default.
- W2104242553 cites W2116403966 @default.
- W2104242553 cites W2121981412 @default.
- W2104242553 cites W2138727941 @default.
- W2104242553 cites W2275165869 @default.
- W2104242553 cites W2350857556 @default.
- W2104242553 cites W2412242604 @default.
- W2104242553 cites W2415372781 @default.
- W2104242553 cites W2416272968 @default.
- W2104242553 cites W2416650146 @default.
- W2104242553 cites W279026874 @default.
- W2104242553 cites W3005434895 @default.
- W2104242553 cites W4211131955 @default.
- W2104242553 cites W95673823 @default.
- W2104242553 cites W2124484803 @default.
- W2104242553 doi "https://doi.org/10.1517/13543784.8.12.2189" @default.
- W2104242553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11139848" @default.
- W2104242553 hasPublicationYear "1999" @default.
- W2104242553 type Work @default.
- W2104242553 sameAs 2104242553 @default.
- W2104242553 citedByCount "25" @default.
- W2104242553 countsByYear W21042425532014 @default.
- W2104242553 countsByYear W21042425532017 @default.
- W2104242553 countsByYear W21042425532022 @default.
- W2104242553 crossrefType "journal-article" @default.
- W2104242553 hasAuthorship W2104242553A5011817630 @default.
- W2104242553 hasAuthorship W2104242553A5034791164 @default.
- W2104242553 hasConcept C109159458 @default.
- W2104242553 hasConcept C150903083 @default.
- W2104242553 hasConcept C154317977 @default.
- W2104242553 hasConcept C184235292 @default.
- W2104242553 hasConcept C195794163 @default.
- W2104242553 hasConcept C201750760 @default.
- W2104242553 hasConcept C202751555 @default.
- W2104242553 hasConcept C203014093 @default.
- W2104242553 hasConcept C207001950 @default.
- W2104242553 hasConcept C28328180 @default.
- W2104242553 hasConcept C2910806222 @default.
- W2104242553 hasConcept C502942594 @default.
- W2104242553 hasConcept C55493867 @default.
- W2104242553 hasConcept C86803240 @default.
- W2104242553 hasConcept C95444343 @default.
- W2104242553 hasConcept C98274493 @default.
- W2104242553 hasConceptScore W2104242553C109159458 @default.
- W2104242553 hasConceptScore W2104242553C150903083 @default.
- W2104242553 hasConceptScore W2104242553C154317977 @default.
- W2104242553 hasConceptScore W2104242553C184235292 @default.
- W2104242553 hasConceptScore W2104242553C195794163 @default.
- W2104242553 hasConceptScore W2104242553C201750760 @default.
- W2104242553 hasConceptScore W2104242553C202751555 @default.
- W2104242553 hasConceptScore W2104242553C203014093 @default.
- W2104242553 hasConceptScore W2104242553C207001950 @default.
- W2104242553 hasConceptScore W2104242553C28328180 @default.