FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104250472> ?p ?o ?g. }

• W2104250472 endingPage "10781" @default.
• W2104250472 startingPage "10774" @default.
• W2104250472 abstract "Abstract Overexpression of cyclin D1 is associated with many cancers, and its overexpression is especially associated with a poor prognosis in breast cancer. Paradoxically, cyclin D1 is known to enhance radiation sensitivity, a finding that has not yet been therapeutically exploited. Proposed cyclin D1 functions that could be involved in this effect include cyclin-dependent kinase (CDK)–dependent phosphorylation of retinoblastoma gene product (pRb), titration of p21/p27 complexes, and less well-characterized effects on gene expression. In this report, we sought to clarify the functions of cyclin D1 that might contribute to enhanced radiation sensitivity. Breast cancer cells stably overexpressing a cyclin D1 mutant (KE) that cannot interact with its CDK partners to phosphorylate pRb were as radiation sensitive as those expressing wild-type D1. Although cyclin D1 has been proposed to affect radiation sensitivity through interactions with p21, a cyclin D1 mutant defective for p21 interactions also increased radiation sensitivity. Cyclin D1 overexpression is generally confined to hormone receptor–positive breast cancers, wherein standard therapies include both radiation and hormonal therapies. Among several proposed CDK-independent cyclin D1 targets, we have identified heat shock protein B8 (HSPB8) as a target particularly associated with cyclin D1 and ER-positive tumors. We therefore evaluated its potential contribution to radiation sensitivity. Overexpression of HSPB8 markedly increased radiation sensitivity, and HSPB8 small interfering RNA blocked cyclin D1's enhancement of radiation sensitivity. Taken together, our results show that some of cyclin D1's effects on radiation sensitivity are CDK and p21 independent and identify HSPB8 as a candidate CDK-independent cyclin D1 target that can mediate its effects. [Cancer Res 2007;67(22):10774–81]" @default.
• W2104250472 created "2016-06-24" @default.
• W2104250472 creator A5001365188 @default.
• W2104250472 creator A5018094670 @default.
• W2104250472 creator A5024272293 @default.
• W2104250472 creator A5042503296 @default.
• W2104250472 creator A5067945065 @default.
• W2104250472 date "2007-11-15" @default.
• W2104250472 modified "2023-10-10" @default.
• W2104250472 title "Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity" @default.
• W2104250472 cites W123650933 @default.
• W2104250472 cites W1982853521 @default.
• W2104250472 cites W1986993149 @default.
• W2104250472 cites W1987597886 @default.
• W2104250472 cites W1991054314 @default.
• W2104250472 cites W2005156019 @default.
• W2104250472 cites W2014067310 @default.
• W2104250472 cites W2014620140 @default.
• W2104250472 cites W2019313913 @default.
• W2104250472 cites W2026251993 @default.
• W2104250472 cites W2027304309 @default.
• W2104250472 cites W2035073888 @default.
• W2104250472 cites W2042545369 @default.
• W2104250472 cites W2043468165 @default.
• W2104250472 cites W2046319047 @default.
• W2104250472 cites W2052097009 @default.
• W2104250472 cites W2058879820 @default.
• W2104250472 cites W2060259713 @default.
• W2104250472 cites W2060990273 @default.
• W2104250472 cites W2061909885 @default.
• W2104250472 cites W2066819549 @default.
• W2104250472 cites W2067420088 @default.
• W2104250472 cites W2076356585 @default.
• W2104250472 cites W2080677621 @default.
• W2104250472 cites W2082364878 @default.
• W2104250472 cites W2082668371 @default.
• W2104250472 cites W2088652363 @default.
• W2104250472 cites W2089628383 @default.
• W2104250472 cites W2102942479 @default.
• W2104250472 cites W2103543394 @default.
• W2104250472 cites W2110320535 @default.
• W2104250472 cites W2121664015 @default.
• W2104250472 cites W2121948931 @default.
• W2104250472 cites W2124818074 @default.
• W2104250472 cites W2127428159 @default.
• W2104250472 cites W2128739161 @default.
• W2104250472 cites W2129036353 @default.
• W2104250472 cites W2129138172 @default.
• W2104250472 cites W2136534513 @default.
• W2104250472 cites W2138798180 @default.
• W2104250472 cites W2139860222 @default.
• W2104250472 cites W2142739240 @default.
• W2104250472 cites W2144871683 @default.
• W2104250472 cites W2149455283 @default.
• W2104250472 cites W2166529745 @default.
• W2104250472 cites W2320272860 @default.
• W2104250472 cites W2334830694 @default.
• W2104250472 cites W4245248225 @default.
• W2104250472 doi "https://doi.org/10.1158/0008-5472.can-07-1475" @default.
• W2104250472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18006821" @default.
• W2104250472 hasPublicationYear "2007" @default.
• W2104250472 type Work @default.
• W2104250472 sameAs 2104250472 @default.
• W2104250472 citedByCount "15" @default.
• W2104250472 countsByYear W21042504722012 @default.
• W2104250472 countsByYear W21042504722014 @default.
• W2104250472 countsByYear W21042504722017 @default.
• W2104250472 countsByYear W21042504722018 @default.
• W2104250472 countsByYear W21042504722021 @default.
• W2104250472 countsByYear W21042504722022 @default.
• W2104250472 crossrefType "journal-article" @default.
• W2104250472 hasAuthorship W2104250472A5001365188 @default.
• W2104250472 hasAuthorship W2104250472A5018094670 @default.
• W2104250472 hasAuthorship W2104250472A5024272293 @default.
• W2104250472 hasAuthorship W2104250472A5042503296 @default.
• W2104250472 hasAuthorship W2104250472A5067945065 @default.
• W2104250472 hasBestOaLocation W21042504721 @default.
• W2104250472 hasConcept C11882975 @default.
• W2104250472 hasConcept C120089663 @default.
• W2104250472 hasConcept C121608353 @default.
• W2104250472 hasConcept C124320809 @default.
• W2104250472 hasConcept C16438837 @default.
• W2104250472 hasConcept C199835354 @default.
• W2104250472 hasConcept C28179978 @default.
• W2104250472 hasConcept C29537977 @default.
• W2104250472 hasConcept C502942594 @default.
• W2104250472 hasConcept C54355233 @default.
• W2104250472 hasConcept C86803240 @default.
• W2104250472 hasConcept C95444343 @default.
• W2104250472 hasConcept C9743823 @default.
• W2104250472 hasConceptScore W2104250472C11882975 @default.
• W2104250472 hasConceptScore W2104250472C120089663 @default.
• W2104250472 hasConceptScore W2104250472C121608353 @default.
• W2104250472 hasConceptScore W2104250472C124320809 @default.
• W2104250472 hasConceptScore W2104250472C16438837 @default.
• W2104250472 hasConceptScore W2104250472C199835354 @default.
• W2104250472 hasConceptScore W2104250472C28179978 @default.
• W2104250472 hasConceptScore W2104250472C29537977 @default.

• next