Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104264349> ?p ?o ?g. }
- W2104264349 endingPage "3033" @default.
- W2104264349 startingPage "3024" @default.
- W2104264349 abstract "Abstract Insulin-like growth factor binding protein-3 (IGFBP-3), the product of a tumor suppressor target gene, can modulate cell proliferation and apoptosis by IGF-I-dependent and IGF-I-independent mechanisms. IGFBP-3 controls the bioavailability of IGFs in the extracellular environment and is known to be subject to degradation by various extracellular proteases. Although nuclear localization and functions of IGFBP-3 have been described in the past, we show as the novel features of this study that the abundance of nuclear IGFBP-3 is directly regulated by ubiquitin/proteasome–dependent proteolysis. We show that IGFBP-3 degradation depends on an active ubiquitin-E1 ligase, specific 26S proteasome inhibitors can efficiently stabilize nuclear IGFBP-3, and the metabolic half-life of nuclear IGFBP-3 is strongly reduced relative to cytoplasmic IGFBP-3. Nuclear IGFBP-3 is highly polyubiquitinated at multiple lysine residues in its conserved COOH-terminal domain and stabilized through mutation of two COOH-terminal lysine residues. Moreover, we show that IGFBP-3, if ectopically expressed in the nucleus, can induce apoptotic cell death. These results suggest that ubiquitin/proteasome–mediated proteolysis of IGFBP-3 may contribute to down-regulation of apoptosis. (Cancer Res 2006; 66(6): 3024-33)" @default.
- W2104264349 created "2016-06-24" @default.
- W2104264349 creator A5001620287 @default.
- W2104264349 creator A5007353087 @default.
- W2104264349 creator A5025294735 @default.
- W2104264349 creator A5042830044 @default.
- W2104264349 creator A5045918942 @default.
- W2104264349 creator A5049570825 @default.
- W2104264349 creator A5054853327 @default.
- W2104264349 creator A5069719268 @default.
- W2104264349 creator A5072514779 @default.
- W2104264349 creator A5075605800 @default.
- W2104264349 creator A5076215352 @default.
- W2104264349 date "2006-03-15" @default.
- W2104264349 modified "2023-10-18" @default.
- W2104264349 title "Nuclear Insulin-Like Growth Factor Binding Protein-3 Induces Apoptosis and Is Targeted to Ubiquitin/Proteasome–Dependent Proteolysis" @default.
- W2104264349 cites W1762826881 @default.
- W2104264349 cites W1977236952 @default.
- W2104264349 cites W1978008638 @default.
- W2104264349 cites W1979741190 @default.
- W2104264349 cites W1988088522 @default.
- W2104264349 cites W1991822698 @default.
- W2104264349 cites W1996675458 @default.
- W2104264349 cites W2002223631 @default.
- W2104264349 cites W2004641065 @default.
- W2104264349 cites W2008744347 @default.
- W2104264349 cites W2012505775 @default.
- W2104264349 cites W2020368904 @default.
- W2104264349 cites W2027207524 @default.
- W2104264349 cites W2027454234 @default.
- W2104264349 cites W2028147924 @default.
- W2104264349 cites W2029098538 @default.
- W2104264349 cites W2037922730 @default.
- W2104264349 cites W2049480315 @default.
- W2104264349 cites W2053099348 @default.
- W2104264349 cites W2053296976 @default.
- W2104264349 cites W2069408483 @default.
- W2104264349 cites W2071085645 @default.
- W2104264349 cites W2077956417 @default.
- W2104264349 cites W2078902093 @default.
- W2104264349 cites W2086867296 @default.
- W2104264349 cites W2100837269 @default.
- W2104264349 cites W2116907551 @default.
- W2104264349 cites W2141195019 @default.
- W2104264349 cites W2147368157 @default.
- W2104264349 cites W2159831275 @default.
- W2104264349 cites W2164895413 @default.
- W2104264349 cites W2166987747 @default.
- W2104264349 cites W2169677569 @default.
- W2104264349 cites W2170407972 @default.
- W2104264349 cites W4229495224 @default.
- W2104264349 doi "https://doi.org/10.1158/0008-5472.can-05-2013" @default.
- W2104264349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16540651" @default.
- W2104264349 hasPublicationYear "2006" @default.
- W2104264349 type Work @default.
- W2104264349 sameAs 2104264349 @default.
- W2104264349 citedByCount "69" @default.
- W2104264349 countsByYear W21042643492012 @default.
- W2104264349 countsByYear W21042643492013 @default.
- W2104264349 countsByYear W21042643492014 @default.
- W2104264349 countsByYear W21042643492015 @default.
- W2104264349 countsByYear W21042643492016 @default.
- W2104264349 countsByYear W21042643492017 @default.
- W2104264349 countsByYear W21042643492018 @default.
- W2104264349 countsByYear W21042643492020 @default.
- W2104264349 countsByYear W21042643492021 @default.
- W2104264349 countsByYear W21042643492022 @default.
- W2104264349 countsByYear W21042643492023 @default.
- W2104264349 crossrefType "journal-article" @default.
- W2104264349 hasAuthorship W2104264349A5001620287 @default.
- W2104264349 hasAuthorship W2104264349A5007353087 @default.
- W2104264349 hasAuthorship W2104264349A5025294735 @default.
- W2104264349 hasAuthorship W2104264349A5042830044 @default.
- W2104264349 hasAuthorship W2104264349A5045918942 @default.
- W2104264349 hasAuthorship W2104264349A5049570825 @default.
- W2104264349 hasAuthorship W2104264349A5054853327 @default.
- W2104264349 hasAuthorship W2104264349A5069719268 @default.
- W2104264349 hasAuthorship W2104264349A5072514779 @default.
- W2104264349 hasAuthorship W2104264349A5075605800 @default.
- W2104264349 hasAuthorship W2104264349A5076215352 @default.
- W2104264349 hasBestOaLocation W21042643491 @default.
- W2104264349 hasConcept C104317684 @default.
- W2104264349 hasConcept C134459356 @default.
- W2104264349 hasConcept C170493617 @default.
- W2104264349 hasConcept C181199279 @default.
- W2104264349 hasConcept C190062978 @default.
- W2104264349 hasConcept C190283241 @default.
- W2104264349 hasConcept C25602115 @default.
- W2104264349 hasConcept C27740335 @default.
- W2104264349 hasConcept C2775960820 @default.
- W2104264349 hasConcept C2780114586 @default.
- W2104264349 hasConcept C2781307694 @default.
- W2104264349 hasConcept C29512474 @default.
- W2104264349 hasConcept C2992195973 @default.
- W2104264349 hasConcept C54757728 @default.
- W2104264349 hasConcept C55493867 @default.
- W2104264349 hasConcept C62112901 @default.
- W2104264349 hasConcept C86339819 @default.