FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104264718> ?p ?o ?g. }

• W2104264718 endingPage "824" @default.
• W2104264718 startingPage "816" @default.
• W2104264718 abstract "Chédiak-Higashi syndrome (C-HS) is a rare congenital disease characterized by defective neutrophil function with abnormal lysosomal inclusions, neutropenia, and reduced chemotaxis. The complete syndrome includes oculocutaneous albinism with photophobia, neurologic features, recurrent infections, and enterocolitis.A 14-year-old male C-HS patient was referred to us because of serious periodontal destruction with acute inflamed gingiva and ulcers. Clinical and biological investigations were performed, leading to the diagnosis of C-HS.Laboratory findings included neutropenia and hypergammaglobulinemia. Peripheral blood smears showed giant granules in neutrophils, eosinophils, and granulocytes. Bone marrow smears showed giant inclusions in leukocyte precursor cells. These granules and inclusions were characteristic of Chédiak-Higashi syndrome. Oral radiographic status showed extensive loss of alveolar bone leading, in most cases, to tooth exfoliation. Bacteria often associated with periodontitis were detected in subgingival plaque samples, including Fusobacterium nucleatum, Campylobacter rectus, Prevotella melaninogenica, Peptostreptococcus anaerobius, and Clostridium sp. Biopsies of periodontal tissues for light and electronic microscopic examinations revealed massive bacterial invasion of the epithelial tissue, epithelial cells, and connective tissue. Ultrastructural observations of periodontal polymorphonuclear leukocytes showed defective granulation, with abnormal granules not discharging their lysosomal content against engulfed bacteria. Viable dividing bacteria were found in the cytoplasm.In this case, early-onset periodontitis seems to be the expression of C-HS granulocyte deficiency. Periodontal treatment of these patients is often unsuccessful. This case report illustrates the importance of the dentist in initiating clinical and biological investigations in such early aggressive periodontitis in young patients." @default.
• W2104264718 created "2016-06-24" @default.
• W2104264718 creator A5016726243 @default.
• W2104264718 creator A5072895125 @default.
• W2104264718 creator A5084938354 @default.
• W2104264718 date "2000-05-01" @default.
• W2104264718 modified "2023-10-11" @default.
• W2104264718 title "Features of Severe Periodontal Disease in a Teenager With Chédiak‐Higashi Syndrome" @default.
• W2104264718 cites W131167820 @default.
• W2104264718 cites W142229570 @default.
• W2104264718 cites W1488320419 @default.
• W2104264718 cites W1605505702 @default.
• W2104264718 cites W1848056131 @default.
• W2104264718 cites W1962573057 @default.
• W2104264718 cites W1964674746 @default.
• W2104264718 cites W1988887659 @default.
• W2104264718 cites W1991104641 @default.
• W2104264718 cites W2003310710 @default.
• W2104264718 cites W2004509759 @default.
• W2104264718 cites W2006406431 @default.
• W2104264718 cites W2007804862 @default.
• W2104264718 cites W2014226888 @default.
• W2104264718 cites W2017331024 @default.
• W2104264718 cites W2025842896 @default.
• W2104264718 cites W2029068973 @default.
• W2104264718 cites W2039274139 @default.
• W2104264718 cites W2043505194 @default.
• W2104264718 cites W2044251889 @default.
• W2104264718 cites W2049479819 @default.
• W2104264718 cites W2050233853 @default.
• W2104264718 cites W2054893783 @default.
• W2104264718 cites W2055865781 @default.
• W2104264718 cites W2061481433 @default.
• W2104264718 cites W2066317597 @default.
• W2104264718 cites W2074403327 @default.
• W2104264718 cites W2083667601 @default.
• W2104264718 cites W2087708213 @default.
• W2104264718 cites W2124510736 @default.
• W2104264718 cites W2142596760 @default.
• W2104264718 cites W2149537794 @default.
• W2104264718 cites W2153300771 @default.
• W2104264718 cites W2334694198 @default.
• W2104264718 cites W2408907270 @default.
• W2104264718 cites W2988207268 @default.
• W2104264718 doi "https://doi.org/10.1902/jop.2000.71.5.816" @default.
• W2104264718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10872965" @default.
• W2104264718 hasPublicationYear "2000" @default.
• W2104264718 type Work @default.
• W2104264718 sameAs 2104264718 @default.
• W2104264718 citedByCount "59" @default.
• W2104264718 countsByYear W21042647182012 @default.
• W2104264718 countsByYear W21042647182013 @default.
• W2104264718 countsByYear W21042647182014 @default.
• W2104264718 countsByYear W21042647182015 @default.
• W2104264718 countsByYear W21042647182016 @default.
• W2104264718 countsByYear W21042647182017 @default.
• W2104264718 countsByYear W21042647182018 @default.
• W2104264718 countsByYear W21042647182019 @default.
• W2104264718 countsByYear W21042647182021 @default.
• W2104264718 countsByYear W21042647182022 @default.
• W2104264718 countsByYear W21042647182023 @default.
• W2104264718 crossrefType "journal-article" @default.
• W2104264718 hasAuthorship W2104264718A5016726243 @default.
• W2104264718 hasAuthorship W2104264718A5072895125 @default.
• W2104264718 hasAuthorship W2104264718A5084938354 @default.
• W2104264718 hasConcept C126322002 @default.
• W2104264718 hasConcept C142724271 @default.
• W2104264718 hasConcept C2777063308 @default.
• W2104264718 hasConcept C2778883934 @default.
• W2104264718 hasConcept C2780385504 @default.
• W2104264718 hasConcept C29730261 @default.
• W2104264718 hasConcept C71924100 @default.
• W2104264718 hasConceptScore W2104264718C126322002 @default.
• W2104264718 hasConceptScore W2104264718C142724271 @default.
• W2104264718 hasConceptScore W2104264718C2777063308 @default.
• W2104264718 hasConceptScore W2104264718C2778883934 @default.
• W2104264718 hasConceptScore W2104264718C2780385504 @default.
• W2104264718 hasConceptScore W2104264718C29730261 @default.
• W2104264718 hasConceptScore W2104264718C71924100 @default.
• W2104264718 hasIssue "5" @default.
• W2104264718 hasLocation W21042647181 @default.
• W2104264718 hasLocation W21042647182 @default.
• W2104264718 hasOpenAccess W2104264718 @default.
• W2104264718 hasPrimaryLocation W21042647181 @default.
• W2104264718 hasRelatedWork W2037522393 @default.
• W2104264718 hasRelatedWork W2083927166 @default.
• W2104264718 hasRelatedWork W2131684681 @default.
• W2104264718 hasRelatedWork W2388942987 @default.
• W2104264718 hasRelatedWork W2748952813 @default.
• W2104264718 hasRelatedWork W2899084033 @default.
• W2104264718 hasRelatedWork W2908611795 @default.
• W2104264718 hasRelatedWork W3031052312 @default.
• W2104264718 hasRelatedWork W3137236382 @default.
• W2104264718 hasRelatedWork W4384627412 @default.
• W2104264718 hasVolume "71" @default.
• W2104264718 isParatext "false" @default.
• W2104264718 isRetracted "false" @default.
• W2104264718 magId "2104264718" @default.

• next