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• W2104280132 abstract "Human cytomegalovirus (HCMV) is a human pathogen that causes severe disease primarily in the immunocompromised or immunologically immature individual. To date, no vaccine is available. We describe use of a spread-deficient murine CMV (MCMV) as a novel approach for betaherpesvirus vaccination. To generate a spread-deficient MCMV, the conserved, essential gene M94 was deleted. Immunization with MCMV-DeltaM94 is apathogenic and protective against wild-type challenge even in highly susceptible IFNalphabetaR(-/-) mice. MCMV-DeltaM94 was able to induce a robust CD4(+) and CD8(+) T-cell response as well as a neutralizing antibody response comparable to that induced by wild-type infection. Endothelial cells were identified as activators of CD8(+) T cells in vivo. Thus, the vaccination with a spread-deficient betaherpesvirus is a safe and protective strategy and allows the linkage between cell tropism and immunogenicity. Furthermore, genomes of MCMV-DeltaM94 were present in lungs 12 months after infection, revealing first-target cells as sites of genome maintenance." @default.
• W2104280132 created "2016-06-24" @default.
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• W2104280132 date "2010-08-01" @default.
• W2104280132 modified "2023-10-10" @default.
• W2104280132 title "A Spread-Deficient Cytomegalovirus for Assessment of First-Target Cells in Vaccination" @default.
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• W2104280132 doi "https://doi.org/10.1128/jvi.02696-09" @default.
• W2104280132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2897632" @default.
• W2104280132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20463067" @default.
• W2104280132 hasPublicationYear "2010" @default.
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