FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104310011> ?p ?o ?g. }

• W2104310011 endingPage "321" @default.
• W2104310011 startingPage "315" @default.
• W2104310011 abstract "We hypothesise that elafin levels in acute lung injury (ALI) decrease over time due, in part, to proteolytic degradation as observed in other lung diseases.The aim of this study was to characterise temporal changes in elafin concentration in patients with ALI and to evaluate whether a decrease in elafin levels is due to elevated protease activity.Bronchoalveolar lavage fluid (BALF) was obtained from patients with ALI within 48 h of onset of ALI (day 0), at day 3 and at day 7. Elafin levels were quantified by ELISA. Elafin susceptibility to proteolytic cleavage by ALI BALF was assessed by Western blot and by high-performance liquid chromatography-mass spectrometry.Elafin levels were found to be significantly increased at the onset of ALI compared with healthy volunteers and fell significantly by day 7 compared with day 0. In contrast, levels of secretory leukocyte protease inhibitor did not decrease over time. This decrease in elafin was due to cleavage by the 20S proteasome which was significantly increased in ALI BALF. Incubation of ALI BALF with the proteasome inhibitor epoxomicin confirmed that 20S proteasome protease activity was responsible for proteolytic cleavage of elafin, resulting in diminished anti-elastase activity. In addition, free neutrophil elastase activity significantly increased in ALI BALF from day 0 to day 7.Elafin concentrations fall within the pulmonary compartment over the course of ALI as a result of proteolytic degradation. This loss of elafin may predispose people, in part, to excessive inflammation in ALI." @default.
• W2104310011 created "2016-06-24" @default.
• W2104310011 creator A5006555219 @default.
• W2104310011 creator A5010713078 @default.
• W2104310011 creator A5024163181 @default.
• W2104310011 creator A5026447171 @default.
• W2104310011 creator A5041103166 @default.
• W2104310011 creator A5044994221 @default.
• W2104310011 creator A5090465570 @default.
• W2104310011 creator A5090917799 @default.
• W2104310011 date "2012-12-14" @default.
• W2104310011 modified "2023-10-13" @default.
• W2104310011 title "Proteolytic cleavage of elafin by 20S proteasome may contribute to inflammation in acute lung injury" @default.
• W2104310011 cites W1533763876 @default.
• W2104310011 cites W1587808121 @default.
• W2104310011 cites W1849505552 @default.
• W2104310011 cites W1892829132 @default.
• W2104310011 cites W1915703237 @default.
• W2104310011 cites W1974659792 @default.
• W2104310011 cites W1976241937 @default.
• W2104310011 cites W1979687908 @default.
• W2104310011 cites W1999171118 @default.
• W2104310011 cites W2000946819 @default.
• W2104310011 cites W2006623674 @default.
• W2104310011 cites W2006944953 @default.
• W2104310011 cites W2007988258 @default.
• W2104310011 cites W2009600179 @default.
• W2104310011 cites W2009612363 @default.
• W2104310011 cites W2011406573 @default.
• W2104310011 cites W2020328354 @default.
• W2104310011 cites W2035053114 @default.
• W2104310011 cites W2044394102 @default.
• W2104310011 cites W2045145961 @default.
• W2104310011 cites W2051676968 @default.
• W2104310011 cites W2054724293 @default.
• W2104310011 cites W2061766973 @default.
• W2104310011 cites W2066095535 @default.
• W2104310011 cites W2068854215 @default.
• W2104310011 cites W2093717452 @default.
• W2104310011 cites W2095239148 @default.
• W2104310011 cites W2113603422 @default.
• W2104310011 cites W2116146921 @default.
• W2104310011 cites W2123579792 @default.
• W2104310011 cites W2134622012 @default.
• W2104310011 cites W2137522692 @default.
• W2104310011 cites W2155279171 @default.
• W2104310011 cites W2182077226 @default.
• W2104310011 cites W2212977866 @default.
• W2104310011 cites W2331857781 @default.
• W2104310011 cites W3034759104 @default.
• W2104310011 cites W34521598 @default.
• W2104310011 doi "https://doi.org/10.1136/thoraxjnl-2012-202536" @default.
• W2104310011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23242946" @default.
• W2104310011 hasPublicationYear "2012" @default.
• W2104310011 type Work @default.
• W2104310011 sameAs 2104310011 @default.
• W2104310011 citedByCount "14" @default.
• W2104310011 countsByYear W21043100112014 @default.
• W2104310011 countsByYear W21043100112015 @default.
• W2104310011 countsByYear W21043100112016 @default.
• W2104310011 countsByYear W21043100112017 @default.
• W2104310011 countsByYear W21043100112020 @default.
• W2104310011 countsByYear W21043100112021 @default.
• W2104310011 countsByYear W21043100112022 @default.
• W2104310011 crossrefType "journal-article" @default.
• W2104310011 hasAuthorship W2104310011A5006555219 @default.
• W2104310011 hasAuthorship W2104310011A5010713078 @default.
• W2104310011 hasAuthorship W2104310011A5024163181 @default.
• W2104310011 hasAuthorship W2104310011A5026447171 @default.
• W2104310011 hasAuthorship W2104310011A5041103166 @default.
• W2104310011 hasAuthorship W2104310011A5044994221 @default.
• W2104310011 hasAuthorship W2104310011A5090465570 @default.
• W2104310011 hasAuthorship W2104310011A5090917799 @default.
• W2104310011 hasBestOaLocation W21043100111 @default.
• W2104310011 hasConcept C126322002 @default.
• W2104310011 hasConcept C181199279 @default.
• W2104310011 hasConcept C185592680 @default.
• W2104310011 hasConcept C203014093 @default.
• W2104310011 hasConcept C27740335 @default.
• W2104310011 hasConcept C2776088058 @default.
• W2104310011 hasConcept C2776317360 @default.
• W2104310011 hasConcept C2776714187 @default.
• W2104310011 hasConcept C2776914184 @default.
• W2104310011 hasConcept C2777714996 @default.
• W2104310011 hasConcept C2777961210 @default.
• W2104310011 hasConcept C2781044401 @default.
• W2104310011 hasConcept C2781307694 @default.
• W2104310011 hasConcept C55493867 @default.
• W2104310011 hasConcept C71924100 @default.
• W2104310011 hasConceptScore W2104310011C126322002 @default.
• W2104310011 hasConceptScore W2104310011C181199279 @default.
• W2104310011 hasConceptScore W2104310011C185592680 @default.
• W2104310011 hasConceptScore W2104310011C203014093 @default.
• W2104310011 hasConceptScore W2104310011C27740335 @default.
• W2104310011 hasConceptScore W2104310011C2776088058 @default.
• W2104310011 hasConceptScore W2104310011C2776317360 @default.
• W2104310011 hasConceptScore W2104310011C2776714187 @default.
• W2104310011 hasConceptScore W2104310011C2776914184 @default.

• next