Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104311978> ?p ?o ?g. }
- W2104311978 endingPage "531" @default.
- W2104311978 startingPage "519" @default.
- W2104311978 abstract "In general, DNA methylation acts in concert with other epigenetic processes, including histone modifications, chromatin remodeling and microRNAs, to shape the overall chromatin structure of the nucleus and potentially modify its functional state. Aberrant DNA methylation events can occur in a number of human diseases but we are only just beginning to appreciate the scope and magnitude of this process in human health. As one example, in contrast to normal cells, the cancer methylome is characterized by reciprocal hypermethylation of specific regulatory regions of genes along with an overall decrease in the quantity of 5-methylcytosine throughout the remainder of the genome. Currently, near genome-wide technologies are available and have been utilized to examine the extent of DNA methylation in discovery-based studies involving several physiological and disease states. Although early in the process, DNA methylation is being explored as a biomarker to be used in clinical practice for early detection of disease, tumor classification and for predicting disease outcome or recurrence. This perspective focuses on the current and future states of the use of DNA methylation biomarkers in disease diagnosis, prognosis and classification, with a particular emphasis on cancer." @default.
- W2104311978 created "2016-06-24" @default.
- W2104311978 creator A5001516916 @default.
- W2104311978 creator A5035776237 @default.
- W2104311978 creator A5061372791 @default.
- W2104311978 date "2007-09-01" @default.
- W2104311978 modified "2023-10-18" @default.
- W2104311978 title "CpG islands: their potential as biomarkers for cancer" @default.
- W2104311978 cites W1570853396 @default.
- W2104311978 cites W1755052449 @default.
- W2104311978 cites W1821797507 @default.
- W2104311978 cites W1916639144 @default.
- W2104311978 cites W1965263399 @default.
- W2104311978 cites W1965722916 @default.
- W2104311978 cites W1967064280 @default.
- W2104311978 cites W1968263601 @default.
- W2104311978 cites W1969073965 @default.
- W2104311978 cites W1969373767 @default.
- W2104311978 cites W1971708895 @default.
- W2104311978 cites W1977860512 @default.
- W2104311978 cites W1979863914 @default.
- W2104311978 cites W1980367947 @default.
- W2104311978 cites W1982541898 @default.
- W2104311978 cites W1988563687 @default.
- W2104311978 cites W1990381590 @default.
- W2104311978 cites W1994057432 @default.
- W2104311978 cites W1994465394 @default.
- W2104311978 cites W1996342200 @default.
- W2104311978 cites W1997890656 @default.
- W2104311978 cites W1999464755 @default.
- W2104311978 cites W2004078197 @default.
- W2104311978 cites W2004172747 @default.
- W2104311978 cites W2007470097 @default.
- W2104311978 cites W2009135094 @default.
- W2104311978 cites W2009811888 @default.
- W2104311978 cites W2012051201 @default.
- W2104311978 cites W2015754967 @default.
- W2104311978 cites W2023071984 @default.
- W2104311978 cites W2029868343 @default.
- W2104311978 cites W2033126903 @default.
- W2104311978 cites W2033709244 @default.
- W2104311978 cites W2034269086 @default.
- W2104311978 cites W2036986058 @default.
- W2104311978 cites W2044616072 @default.
- W2104311978 cites W2046097761 @default.
- W2104311978 cites W2049174408 @default.
- W2104311978 cites W2055916581 @default.
- W2104311978 cites W2060262001 @default.
- W2104311978 cites W2062093164 @default.
- W2104311978 cites W2062098353 @default.
- W2104311978 cites W2063110349 @default.
- W2104311978 cites W2075913610 @default.
- W2104311978 cites W2081279521 @default.
- W2104311978 cites W2086294283 @default.
- W2104311978 cites W2086362276 @default.
- W2104311978 cites W2086990980 @default.
- W2104311978 cites W2095728717 @default.
- W2104311978 cites W2096287539 @default.
- W2104311978 cites W2098192588 @default.
- W2104311978 cites W2098362718 @default.
- W2104311978 cites W2098582295 @default.
- W2104311978 cites W2100489386 @default.
- W2104311978 cites W2100579820 @default.
- W2104311978 cites W2100632164 @default.
- W2104311978 cites W2101037833 @default.
- W2104311978 cites W2101259235 @default.
- W2104311978 cites W2102368084 @default.
- W2104311978 cites W2102841397 @default.
- W2104311978 cites W2103368550 @default.
- W2104311978 cites W2105307866 @default.
- W2104311978 cites W2106680700 @default.
- W2104311978 cites W2107038650 @default.
- W2104311978 cites W2108421119 @default.
- W2104311978 cites W2108546855 @default.
- W2104311978 cites W2109934662 @default.
- W2104311978 cites W2110511887 @default.
- W2104311978 cites W2112448007 @default.
- W2104311978 cites W2113155233 @default.
- W2104311978 cites W2117819670 @default.
- W2104311978 cites W2123174009 @default.
- W2104311978 cites W2127226692 @default.
- W2104311978 cites W2127431151 @default.
- W2104311978 cites W2128025482 @default.
- W2104311978 cites W2128062614 @default.
- W2104311978 cites W2128107471 @default.
- W2104311978 cites W2128114769 @default.
- W2104311978 cites W2133279405 @default.
- W2104311978 cites W2134555277 @default.
- W2104311978 cites W2136932339 @default.
- W2104311978 cites W2140767362 @default.
- W2104311978 cites W2141410747 @default.
- W2104311978 cites W2145103193 @default.
- W2104311978 cites W2145669281 @default.
- W2104311978 cites W2148405421 @default.
- W2104311978 cites W2150027485 @default.
- W2104311978 cites W2151056739 @default.
- W2104311978 cites W2158143138 @default.
- W2104311978 cites W2158567066 @default.