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- W2104318763 endingPage "701" @default.
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- W2104318763 abstract "Enzymes with the (beta/alpha)(8)-barrel fold are involved in the catalysis of a wide variety of biochemical reactions. The active sites of these enzymes are located on the C-terminal face of the central beta-barrel. Conserved amino acid sequence, as well as secondary, tertiary and quaternary structure patterns are providing a rich body of data to support the premise of a common ancestry of many members of the (beta/alpha)(8)-barrel fold family of enzymes. Recent data indicate that there is at least one example of a bienzyme that functions as an ammonia channel, adding a new level of functional diversity to the (beta/alpha)(8)-barrel fold. These proteins have become ideal tools that can be used in conjunction with directed evolution techniques to engineer novel catalytic activities." @default.
- W2104318763 created "2016-06-24" @default.
- W2104318763 creator A5036862367 @default.
- W2104318763 date "2003-12-01" @default.
- W2104318763 modified "2023-10-03" @default.
- W2104318763 title "Evolutionary markers in the (β/α)8-barrel fold" @default.
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- W2104318763 doi "https://doi.org/10.1016/j.cbpa.2003.10.004" @default.
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