Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104320462> ?p ?o ?g. }
- W2104320462 endingPage "7" @default.
- W2104320462 startingPage "1" @default.
- W2104320462 abstract "T cells recognize antigen via the T-cell receptor (TCR) and produce a spectrum of responses that range from activation to anergy or cell death. The variety of outcomes may be dictated by the strength of the signals transmitted upon cognate recognition of the TCR. The physiological outcome of TCR engagement is determined by several factors, including the avidity of the ligand for TCR, the duration of engagement, and the presence and nature of accessory molecules present on antigen-presenting cells (APCs). In this review, we discuss a model of anergy induced by presentation of low densities of peptide-major histocompatibility complex (MHC) ligand in CD4(+) T cells and compare it to anergy induced by altered peptide ligands in an effort to identify a unifying mechanism. We suggest that altered peptide ligand (APL) and low densities of agonist ligands induce anergy by engaging less than optimal numbers of TCRs. The physiological impacts of anergy in memory CD4(+) T cells are discussed." @default.
- W2104320462 created "2016-06-24" @default.
- W2104320462 creator A5007644298 @default.
- W2104320462 creator A5009023489 @default.
- W2104320462 creator A5010388411 @default.
- W2104320462 creator A5057541799 @default.
- W2104320462 date "2009-12-08" @default.
- W2104320462 modified "2023-10-12" @default.
- W2104320462 title "Suboptimal engagement of the T‐cell receptor by a variety of peptide–MHC ligands triggers T‐cell anergy" @default.
- W2104320462 cites W1523147669 @default.
- W2104320462 cites W1533306720 @default.
- W2104320462 cites W1564692715 @default.
- W2104320462 cites W1581000989 @default.
- W2104320462 cites W1645244049 @default.
- W2104320462 cites W1647115901 @default.
- W2104320462 cites W1771845532 @default.
- W2104320462 cites W1833759296 @default.
- W2104320462 cites W187920822 @default.
- W2104320462 cites W1910447160 @default.
- W2104320462 cites W1964741953 @default.
- W2104320462 cites W1966598940 @default.
- W2104320462 cites W1970252429 @default.
- W2104320462 cites W1970735079 @default.
- W2104320462 cites W1972012479 @default.
- W2104320462 cites W1977917052 @default.
- W2104320462 cites W1978790143 @default.
- W2104320462 cites W1987128447 @default.
- W2104320462 cites W1992699522 @default.
- W2104320462 cites W1995925083 @default.
- W2104320462 cites W1998048927 @default.
- W2104320462 cites W1998415250 @default.
- W2104320462 cites W2004680217 @default.
- W2104320462 cites W2005194095 @default.
- W2104320462 cites W2007305532 @default.
- W2104320462 cites W2008182583 @default.
- W2104320462 cites W2014161666 @default.
- W2104320462 cites W2015326650 @default.
- W2104320462 cites W2025783409 @default.
- W2104320462 cites W2028852768 @default.
- W2104320462 cites W2029175134 @default.
- W2104320462 cites W2032169064 @default.
- W2104320462 cites W2035960239 @default.
- W2104320462 cites W2036823751 @default.
- W2104320462 cites W2040573650 @default.
- W2104320462 cites W2041658172 @default.
- W2104320462 cites W2043540369 @default.
- W2104320462 cites W2045527508 @default.
- W2104320462 cites W2052408923 @default.
- W2104320462 cites W2053817261 @default.
- W2104320462 cites W2058811157 @default.
- W2104320462 cites W2059637973 @default.
- W2104320462 cites W2059984497 @default.
- W2104320462 cites W2066331485 @default.
- W2104320462 cites W2074059194 @default.
- W2104320462 cites W2074932405 @default.
- W2104320462 cites W2077864494 @default.
- W2104320462 cites W2078312540 @default.
- W2104320462 cites W2078494443 @default.
- W2104320462 cites W2078523699 @default.
- W2104320462 cites W2081810600 @default.
- W2104320462 cites W2088438876 @default.
- W2104320462 cites W2089010131 @default.
- W2104320462 cites W2089666002 @default.
- W2104320462 cites W2089927981 @default.
- W2104320462 cites W2092972513 @default.
- W2104320462 cites W2095259705 @default.
- W2104320462 cites W2095433140 @default.
- W2104320462 cites W2095520403 @default.
- W2104320462 cites W2096033616 @default.
- W2104320462 cites W2104651168 @default.
- W2104320462 cites W2110572783 @default.
- W2104320462 cites W2112506009 @default.
- W2104320462 cites W2112749175 @default.
- W2104320462 cites W2113069820 @default.
- W2104320462 cites W2125504851 @default.
- W2104320462 cites W2126832747 @default.
- W2104320462 cites W2132156332 @default.
- W2104320462 cites W2134342349 @default.
- W2104320462 cites W2135604731 @default.
- W2104320462 cites W2145341441 @default.
- W2104320462 cites W2145572269 @default.
- W2104320462 cites W2146074801 @default.
- W2104320462 cites W2149764521 @default.
- W2104320462 cites W2153389047 @default.
- W2104320462 cites W2156648441 @default.
- W2104320462 cites W2157486922 @default.
- W2104320462 cites W2159756478 @default.
- W2104320462 cites W2163660675 @default.
- W2104320462 cites W2168485942 @default.
- W2104320462 cites W2172144268 @default.
- W2104320462 cites W2285153579 @default.
- W2104320462 cites W4232229546 @default.
- W2104320462 doi "https://doi.org/10.1111/j.1365-2567.2009.03206.x" @default.
- W2104320462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2807481" @default.
- W2104320462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20002785" @default.
- W2104320462 hasPublicationYear "2009" @default.
- W2104320462 type Work @default.
- W2104320462 sameAs 2104320462 @default.