Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104335391> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2104335391 endingPage "663" @default.
- W2104335391 startingPage "662" @default.
- W2104335391 abstract "Background: Infectious complications and associated mortality are a major concern in acute pancreatitis. Enteral administration of probiotics could prevent infectious complications, but convincing evidence is scarce. Our aim was to assess the effects of probiotic prophylaxis in patients with predicted severe acute pancreatitis. Methods: In this multicenter randomized, double‐blind, placebo‐controlled trial, 298 patients with predicted severe acute pancreatitis (Acute Physiology and Chronic Health Evaluation [APACHE II] score ≥8, Imrie score ≥3, or C‐reactive protein> 150 mg/L) were randomly assigned within 72 h of onset of symptoms to receive a multispecies probiotic preparation (n = 153) or placebo (n = 145), administered enterally twice daily for 28 days. The primary endpoint was the composite of infectious complications—i.e., infected pancreatic necrosis, bacteremia, pneumonia, urosepsis, or infected ascites—during admission and 90‐day follow‐up. Analyses were by intention to treat. This study is registered, number ISRCTN38327949. Findings: One person in each group was excluded from analyses because of incorrect diagnoses of pancreatitis; thus, 152 individuals in the probiotics group and 144 in the placebo group were analysed. Groups were much the same at baseline in terms of patients' characteristics and disease severity. Infectious complications occurred in 46 (30%) patients in the probiotics group and 41 (28%) of those in the placebo group (relative risk 1.06, 95% CI 0.75–1.51). 24 (16%) patients in the probiotics group died, compared with nine (6%) in the placebo group (relative risk 2.53, 95% CI 1.22–5.25). Nine patients in the probiotics group developed bowel ischaemia (eight with fatal outcome), compared with none in the placebo group (p = 0.004). Interpretation: In patients with predicted severe acute pancreatitis, probiotic prophylaxis with this combination of probiotic strains did not reduce the risk of infectious complications and was associated with an increased risk of mortality. Probiotic prophylaxis should therefore not be administered in this category of patients. ( Lancet . 2008;371(9613):651‐659) MGH Besselink, HC van Santvoort, E Buskens, et al, for the Dutch Acute Pancreatitis Study Group" @default.
- W2104335391 created "2016-06-24" @default.
- W2104335391 creator A5018168041 @default.
- W2104335391 date "2008-12-01" @default.
- W2104335391 modified "2023-09-30" @default.
- W2104335391 title "Probiotic Prophylaxis in Predicted Severe Acute Pancreatitis: A Randomised, Double-Blind, Placebo-Controlled Trial" @default.
- W2104335391 cites W1978006468 @default.
- W2104335391 cites W1980527006 @default.
- W2104335391 cites W2112230262 @default.
- W2104335391 doi "https://doi.org/10.1177/0884533608326323" @default.
- W2104335391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29130865" @default.
- W2104335391 hasPublicationYear "2008" @default.
- W2104335391 type Work @default.
- W2104335391 sameAs 2104335391 @default.
- W2104335391 citedByCount "5" @default.
- W2104335391 countsByYear W21043353912017 @default.
- W2104335391 countsByYear W21043353912018 @default.
- W2104335391 countsByYear W21043353912020 @default.
- W2104335391 countsByYear W21043353912021 @default.
- W2104335391 crossrefType "journal-article" @default.
- W2104335391 hasAuthorship W2104335391A5018168041 @default.
- W2104335391 hasConcept C126322002 @default.
- W2104335391 hasConcept C142724271 @default.
- W2104335391 hasConcept C168563851 @default.
- W2104335391 hasConcept C203092338 @default.
- W2104335391 hasConcept C204243189 @default.
- W2104335391 hasConcept C204787440 @default.
- W2104335391 hasConcept C27081682 @default.
- W2104335391 hasConcept C2775967933 @default.
- W2104335391 hasConcept C2776670229 @default.
- W2104335391 hasConcept C2777914695 @default.
- W2104335391 hasConcept C2779443120 @default.
- W2104335391 hasConcept C2780255968 @default.
- W2104335391 hasConcept C44249647 @default.
- W2104335391 hasConcept C501593827 @default.
- W2104335391 hasConcept C523546767 @default.
- W2104335391 hasConcept C54355233 @default.
- W2104335391 hasConcept C71924100 @default.
- W2104335391 hasConcept C82789193 @default.
- W2104335391 hasConcept C86803240 @default.
- W2104335391 hasConcept C89423630 @default.
- W2104335391 hasConcept C90924648 @default.
- W2104335391 hasConceptScore W2104335391C126322002 @default.
- W2104335391 hasConceptScore W2104335391C142724271 @default.
- W2104335391 hasConceptScore W2104335391C168563851 @default.
- W2104335391 hasConceptScore W2104335391C203092338 @default.
- W2104335391 hasConceptScore W2104335391C204243189 @default.
- W2104335391 hasConceptScore W2104335391C204787440 @default.
- W2104335391 hasConceptScore W2104335391C27081682 @default.
- W2104335391 hasConceptScore W2104335391C2775967933 @default.
- W2104335391 hasConceptScore W2104335391C2776670229 @default.
- W2104335391 hasConceptScore W2104335391C2777914695 @default.
- W2104335391 hasConceptScore W2104335391C2779443120 @default.
- W2104335391 hasConceptScore W2104335391C2780255968 @default.
- W2104335391 hasConceptScore W2104335391C44249647 @default.
- W2104335391 hasConceptScore W2104335391C501593827 @default.
- W2104335391 hasConceptScore W2104335391C523546767 @default.
- W2104335391 hasConceptScore W2104335391C54355233 @default.
- W2104335391 hasConceptScore W2104335391C71924100 @default.
- W2104335391 hasConceptScore W2104335391C82789193 @default.
- W2104335391 hasConceptScore W2104335391C86803240 @default.
- W2104335391 hasConceptScore W2104335391C89423630 @default.
- W2104335391 hasConceptScore W2104335391C90924648 @default.
- W2104335391 hasIssue "6" @default.
- W2104335391 hasLocation W21043353911 @default.
- W2104335391 hasLocation W21043353912 @default.
- W2104335391 hasOpenAccess W2104335391 @default.
- W2104335391 hasPrimaryLocation W21043353911 @default.
- W2104335391 hasRelatedWork W1591978428 @default.
- W2104335391 hasRelatedWork W1983673184 @default.
- W2104335391 hasRelatedWork W2039865683 @default.
- W2104335391 hasRelatedWork W2398027573 @default.
- W2104335391 hasRelatedWork W2890098371 @default.
- W2104335391 hasRelatedWork W2975565534 @default.
- W2104335391 hasRelatedWork W2998663103 @default.
- W2104335391 hasRelatedWork W3119275760 @default.
- W2104335391 hasRelatedWork W4244069386 @default.
- W2104335391 hasRelatedWork W55265899 @default.
- W2104335391 hasVolume "23" @default.
- W2104335391 isParatext "false" @default.
- W2104335391 isRetracted "false" @default.
- W2104335391 magId "2104335391" @default.
- W2104335391 workType "article" @default.