Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104339638> ?p ?o ?g. }
- W2104339638 endingPage "1512" @default.
- W2104339638 startingPage "1503" @default.
- W2104339638 abstract "Abstract The leucocyte plays a key role in the local and systemic tissue injury that results from peripheral arterial disease and chronic venous insufficiency. Despite the apparent dissimilarities between limb ischaemia and chronic venous ulceration, in both diseases macrovascular abnormalities lead to microvascular leucocyte trapping and activation. Activated leucocytes adhere to and damage adjacent endothelium by expressing adhesion molecules and releasing harmful moieties such as proteases and free radicals. Subsequent loss of endothelial integrity and the migration of activated leocytes outwith the circulation leads to destruction of surrounding tissue. Leucocytes and their products are also involved in the systemic manifestations of ischaemia such as multiple organ failure and coagulopathy. An overview of leucocyte biology as it pertains to peripheral arterial and venous disease is presented. The opportunities for novel therapeutic interventions based on a better understanding of this biology are also discussed." @default.
- W2104339638 created "2016-06-24" @default.
- W2104339638 creator A5029695998 @default.
- W2104339638 creator A5032360561 @default.
- W2104339638 creator A5080427066 @default.
- W2104339638 date "1993-12-01" @default.
- W2104339638 modified "2023-09-23" @default.
- W2104339638 title "Role of the leucocyte in the pathogenesis of vascular disease" @default.
- W2104339638 cites W1547869235 @default.
- W2104339638 cites W1574330564 @default.
- W2104339638 cites W1748919512 @default.
- W2104339638 cites W186752733 @default.
- W2104339638 cites W1903315309 @default.
- W2104339638 cites W1964044694 @default.
- W2104339638 cites W1964570763 @default.
- W2104339638 cites W1965972035 @default.
- W2104339638 cites W1966743075 @default.
- W2104339638 cites W1969771169 @default.
- W2104339638 cites W1971917696 @default.
- W2104339638 cites W1972353246 @default.
- W2104339638 cites W1973410909 @default.
- W2104339638 cites W1973443459 @default.
- W2104339638 cites W1974486772 @default.
- W2104339638 cites W1976938135 @default.
- W2104339638 cites W1977363772 @default.
- W2104339638 cites W1978417778 @default.
- W2104339638 cites W1979116160 @default.
- W2104339638 cites W1979902199 @default.
- W2104339638 cites W1984338631 @default.
- W2104339638 cites W1985306804 @default.
- W2104339638 cites W1985449894 @default.
- W2104339638 cites W1986336458 @default.
- W2104339638 cites W1988158019 @default.
- W2104339638 cites W1989598568 @default.
- W2104339638 cites W1989658278 @default.
- W2104339638 cites W1990046026 @default.
- W2104339638 cites W1990986033 @default.
- W2104339638 cites W1993194389 @default.
- W2104339638 cites W1998079753 @default.
- W2104339638 cites W1998363691 @default.
- W2104339638 cites W2002008524 @default.
- W2104339638 cites W2002027433 @default.
- W2104339638 cites W2005858585 @default.
- W2104339638 cites W2007375934 @default.
- W2104339638 cites W2008527716 @default.
- W2104339638 cites W2011207006 @default.
- W2104339638 cites W2015471541 @default.
- W2104339638 cites W2015721415 @default.
- W2104339638 cites W2016186842 @default.
- W2104339638 cites W2018874703 @default.
- W2104339638 cites W2019000250 @default.
- W2104339638 cites W2021045520 @default.
- W2104339638 cites W2021823569 @default.
- W2104339638 cites W2023147805 @default.
- W2104339638 cites W2023526357 @default.
- W2104339638 cites W2025072163 @default.
- W2104339638 cites W2026015458 @default.
- W2104339638 cites W2028418732 @default.
- W2104339638 cites W2035211353 @default.
- W2104339638 cites W2035834604 @default.
- W2104339638 cites W2038503324 @default.
- W2104339638 cites W2039639759 @default.
- W2104339638 cites W2042131196 @default.
- W2104339638 cites W2046831069 @default.
- W2104339638 cites W2048519644 @default.
- W2104339638 cites W2049151317 @default.
- W2104339638 cites W2052395633 @default.
- W2104339638 cites W2054433983 @default.
- W2104339638 cites W2055427345 @default.
- W2104339638 cites W2055439470 @default.
- W2104339638 cites W2056225363 @default.
- W2104339638 cites W2059229522 @default.
- W2104339638 cites W2059960043 @default.
- W2104339638 cites W2061427816 @default.
- W2104339638 cites W2061947507 @default.
- W2104339638 cites W2062275980 @default.
- W2104339638 cites W2065447230 @default.
- W2104339638 cites W2065826403 @default.
- W2104339638 cites W2066722580 @default.
- W2104339638 cites W2071986468 @default.
- W2104339638 cites W2072359377 @default.
- W2104339638 cites W2074393911 @default.
- W2104339638 cites W2074845376 @default.
- W2104339638 cites W2075803745 @default.
- W2104339638 cites W2076261384 @default.
- W2104339638 cites W2079033370 @default.
- W2104339638 cites W2079787678 @default.
- W2104339638 cites W2080060134 @default.
- W2104339638 cites W2081120186 @default.
- W2104339638 cites W2082033177 @default.
- W2104339638 cites W2082695343 @default.
- W2104339638 cites W2085870505 @default.
- W2104339638 cites W2088073163 @default.
- W2104339638 cites W2088734405 @default.
- W2104339638 cites W2089160542 @default.
- W2104339638 cites W2089529392 @default.
- W2104339638 cites W2089745556 @default.
- W2104339638 cites W2089801100 @default.