FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104360064> ?p ?o ?g. }

• W2104360064 endingPage "3914" @default.
• W2104360064 startingPage "3911" @default.
• W2104360064 abstract "Based upon molecular allelotyping and comparative genomic hybridization studies, chromosome 15q is the likely location of a tumor suppressor gene important in the pathogeneses of sporadic enteropancreatic endocrine tumors and parathyroid adenomas. Interest has focused on Smad3 as a candidate endocrine tumor suppressor gene because 1) it is localized to 15q and 2) it encodes a TGF beta signaling molecule that has been identified as a binding partner of the multiple endocrine neoplasm type 1 gene product menin, itself involved in enteropancreatic and parathyroid neoplasia. To determine whether Smad3 plays a primary role in development of these tumors, 20 enteropancreatic tumors and 67 parathyroid adenomas were investigated for loss of heterozygosity at DNA markers surrounding Smad3. Twenty percent of enteropancreatic tumors and 24% of parathyroid adenomas showed loss. All 9 coding exons and intron-exon boundaries of the Smad3 gene were then sequenced in genomic DNA from all 20 enteropancreatic and 25 parathyroid tumors, including every case with loss of heterozygosity. No acquired clonal mutations, insertions, or microdeletions in Smad3 were detected in any tumors. Because inactivating somatic mutation is the hallmark of an authentic tumor suppressor, Smad3 is unlikely to function as a classical tumor suppressor gene in the pathogenesis of sporadic parathyroid or enteropancreatic endocrine tumors." @default.
• W2104360064 created "2016-06-24" @default.
• W2104360064 creator A5005161415 @default.
• W2104360064 creator A5026214605 @default.
• W2104360064 creator A5049232174 @default.
• W2104360064 creator A5051982812 @default.
• W2104360064 creator A5078692679 @default.
• W2104360064 creator A5086897381 @default.
• W2104360064 date "2002-08-01" @default.
• W2104360064 modified "2023-10-15" @default.
• W2104360064 title "Mutational Analysis of<i>Smad3</i>, a Candidate Tumor Suppressor Implicated in TGF-β and Menin Pathways, in Parathyroid Adenomas and Enteropancreatic Endocrine Tumors" @default.
• W2104360064 cites W1608269342 @default.
• W2104360064 cites W1701092691 @default.
• W2104360064 cites W1770702054 @default.
• W2104360064 cites W1897269170 @default.
• W2104360064 cites W1974095890 @default.
• W2104360064 cites W1985184743 @default.
• W2104360064 cites W1985434939 @default.
• W2104360064 cites W1985929046 @default.
• W2104360064 cites W1999242125 @default.
• W2104360064 cites W2004195243 @default.
• W2104360064 cites W2017384019 @default.
• W2104360064 cites W2026428548 @default.
• W2104360064 cites W2033887719 @default.
• W2104360064 cites W2036080863 @default.
• W2104360064 cites W2055978739 @default.
• W2104360064 cites W2060319335 @default.
• W2104360064 cites W2063137811 @default.
• W2104360064 cites W2073332144 @default.
• W2104360064 cites W2074883939 @default.
• W2104360064 cites W2075173469 @default.
• W2104360064 cites W2098607769 @default.
• W2104360064 cites W2114324291 @default.
• W2104360064 cites W2116753242 @default.
• W2104360064 cites W2118266070 @default.
• W2104360064 cites W2120114702 @default.
• W2104360064 cites W2141122938 @default.
• W2104360064 cites W2151761027 @default.
• W2104360064 cites W2157212789 @default.
• W2104360064 cites W2167191551 @default.
• W2104360064 cites W2170577183 @default.
• W2104360064 cites W2318686332 @default.
• W2104360064 cites W2474724313 @default.
• W2104360064 doi "https://doi.org/10.1210/jcem.87.8.8707" @default.
• W2104360064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12161532" @default.
• W2104360064 hasPublicationYear "2002" @default.
• W2104360064 type Work @default.
• W2104360064 sameAs 2104360064 @default.
• W2104360064 citedByCount "18" @default.
• W2104360064 countsByYear W21043600642012 @default.
• W2104360064 countsByYear W21043600642013 @default.
• W2104360064 countsByYear W21043600642017 @default.
• W2104360064 countsByYear W21043600642021 @default.
• W2104360064 countsByYear W21043600642023 @default.
• W2104360064 crossrefType "journal-article" @default.
• W2104360064 hasAuthorship W2104360064A5005161415 @default.
• W2104360064 hasAuthorship W2104360064A5026214605 @default.
• W2104360064 hasAuthorship W2104360064A5049232174 @default.
• W2104360064 hasAuthorship W2104360064A5051982812 @default.
• W2104360064 hasAuthorship W2104360064A5078692679 @default.
• W2104360064 hasAuthorship W2104360064A5086897381 @default.
• W2104360064 hasBestOaLocation W21043600641 @default.
• W2104360064 hasConcept C104317684 @default.
• W2104360064 hasConcept C126322002 @default.
• W2104360064 hasConcept C134018914 @default.
• W2104360064 hasConcept C143589142 @default.
• W2104360064 hasConcept C180754005 @default.
• W2104360064 hasConcept C2775945674 @default.
• W2104360064 hasConcept C2778264664 @default.
• W2104360064 hasConcept C2779469564 @default.
• W2104360064 hasConcept C2780103800 @default.
• W2104360064 hasConcept C2780273267 @default.
• W2104360064 hasConcept C2781167329 @default.
• W2104360064 hasConcept C36823959 @default.
• W2104360064 hasConcept C502942594 @default.
• W2104360064 hasConcept C54355233 @default.
• W2104360064 hasConcept C555283112 @default.
• W2104360064 hasConcept C71924100 @default.
• W2104360064 hasConcept C86803240 @default.
• W2104360064 hasConceptScore W2104360064C104317684 @default.
• W2104360064 hasConceptScore W2104360064C126322002 @default.
• W2104360064 hasConceptScore W2104360064C134018914 @default.
• W2104360064 hasConceptScore W2104360064C143589142 @default.
• W2104360064 hasConceptScore W2104360064C180754005 @default.
• W2104360064 hasConceptScore W2104360064C2775945674 @default.
• W2104360064 hasConceptScore W2104360064C2778264664 @default.
• W2104360064 hasConceptScore W2104360064C2779469564 @default.
• W2104360064 hasConceptScore W2104360064C2780103800 @default.
• W2104360064 hasConceptScore W2104360064C2780273267 @default.
• W2104360064 hasConceptScore W2104360064C2781167329 @default.
• W2104360064 hasConceptScore W2104360064C36823959 @default.
• W2104360064 hasConceptScore W2104360064C502942594 @default.
• W2104360064 hasConceptScore W2104360064C54355233 @default.
• W2104360064 hasConceptScore W2104360064C555283112 @default.
• W2104360064 hasConceptScore W2104360064C71924100 @default.
• W2104360064 hasConceptScore W2104360064C86803240 @default.
• W2104360064 hasIssue "8" @default.
• W2104360064 hasLocation W21043600641 @default.

• next