FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104389637> ?p ?o ?g. }

• W2104389637 endingPage "1582" @default.
• W2104389637 startingPage "1574" @default.
• W2104389637 abstract "Background— Patients with postural tachycardia syndrome (POTS) experience considerable disability, but in most, the pathophysiology remains obscure. Plasma volume disturbances have been implicated in some patients. We prospectively tested the hypothesis that patients with POTS are hypovolemic compared with healthy controls and explored the role of plasma renin activity and aldosterone in the regulation of plasma volume. Methods and Results— Patients with POTS (n=15) and healthy controls (n=14) underwent investigation. Heart rate (HR), blood pressure (BP), plasma renin activity, and aldosterone were measured with patients both supine and upright. Blood volumes were measured with 131 I-labeled albumin and hematocrit. Patients with POTS had a higher orthostatic increase in HR than controls (51±18 versus 16±10 bpm, P <0.001). Patients with POTS had a greater deficit in plasma volume (334±187 versus 10±250 mL, P <0.001), red blood cell volume (356±128 versus 218±140 mL, P =0.010), and total blood volume (689±270 versus 228±353 mL, P <0.001) than controls. Despite the lower plasma volume in patients with POTS, there was not a compensatory increase in plasma renin activity (0.79±0.58 versus 0.79±0.74 ng · mL −1 · h −1 , P =0.996). There was a paradoxically low level of aldosterone in the patients with POTS (190±140 pmol/L versus 380±230 pmol/L; P =0.017). Conclusions— Patients with POTS have paradoxically unchanged plasma renin activity and low aldosterone given their marked reduction in plasma volume. These patients also have a significant red blood cell volume deficit, which is regulated by the renal hormone erythropoietin. These abnormalities suggest that the kidney may play a key role in the pathophysiology of POTS." @default.
• W2104389637 created "2016-06-24" @default.
• W2104389637 creator A5003259889 @default.
• W2104389637 creator A5012310290 @default.
• W2104389637 creator A5016719143 @default.
• W2104389637 creator A5032394611 @default.
• W2104389637 creator A5039613624 @default.
• W2104389637 creator A5043883297 @default.
• W2104389637 creator A5049651060 @default.
• W2104389637 date "2005-04-05" @default.
• W2104389637 modified "2023-10-16" @default.
• W2104389637 title "Renin-Aldosterone Paradox and Perturbed Blood Volume Regulation Underlying Postural Tachycardia Syndrome" @default.
• W2104389637 cites W1908174192 @default.
• W2104389637 cites W1983166974 @default.
• W2104389637 cites W1989852271 @default.
• W2104389637 cites W1995274171 @default.
• W2104389637 cites W1998955929 @default.
• W2104389637 cites W2003488252 @default.
• W2104389637 cites W2008882926 @default.
• W2104389637 cites W2021945392 @default.
• W2104389637 cites W2040028854 @default.
• W2104389637 cites W2045445225 @default.
• W2104389637 cites W2054537189 @default.
• W2104389637 cites W2079310325 @default.
• W2104389637 cites W2081646236 @default.
• W2104389637 cites W2090479720 @default.
• W2104389637 cites W2106992761 @default.
• W2104389637 cites W2123169434 @default.
• W2104389637 cites W2123465466 @default.
• W2104389637 cites W2133465432 @default.
• W2104389637 cites W2147610358 @default.
• W2104389637 cites W2151299194 @default.
• W2104389637 cites W2164003699 @default.
• W2104389637 cites W2168827569 @default.
• W2104389637 cites W2239125386 @default.
• W2104389637 cites W2505492416 @default.
• W2104389637 cites W2914847286 @default.
• W2104389637 cites W4244638834 @default.
• W2104389637 cites W4249502863 @default.
• W2104389637 cites W83973244 @default.
• W2104389637 doi "https://doi.org/10.1161/01.cir.0000160356.97313.5d" @default.
• W2104389637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15781744" @default.
• W2104389637 hasPublicationYear "2005" @default.
• W2104389637 type Work @default.
• W2104389637 sameAs 2104389637 @default.
• W2104389637 citedByCount "220" @default.
• W2104389637 countsByYear W21043896372012 @default.
• W2104389637 countsByYear W21043896372013 @default.
• W2104389637 countsByYear W21043896372014 @default.
• W2104389637 countsByYear W21043896372015 @default.
• W2104389637 countsByYear W21043896372016 @default.
• W2104389637 countsByYear W21043896372017 @default.
• W2104389637 countsByYear W21043896372018 @default.
• W2104389637 countsByYear W21043896372019 @default.
• W2104389637 countsByYear W21043896372020 @default.
• W2104389637 countsByYear W21043896372021 @default.
• W2104389637 countsByYear W21043896372022 @default.
• W2104389637 countsByYear W21043896372023 @default.
• W2104389637 crossrefType "journal-article" @default.
• W2104389637 hasAuthorship W2104389637A5003259889 @default.
• W2104389637 hasAuthorship W2104389637A5012310290 @default.
• W2104389637 hasAuthorship W2104389637A5016719143 @default.
• W2104389637 hasAuthorship W2104389637A5032394611 @default.
• W2104389637 hasAuthorship W2104389637A5039613624 @default.
• W2104389637 hasAuthorship W2104389637A5043883297 @default.
• W2104389637 hasAuthorship W2104389637A5049651060 @default.
• W2104389637 hasBestOaLocation W21043896371 @default.
• W2104389637 hasConcept C125567185 @default.
• W2104389637 hasConcept C126322002 @default.
• W2104389637 hasConcept C134018914 @default.
• W2104389637 hasConcept C138976137 @default.
• W2104389637 hasConcept C164705383 @default.
• W2104389637 hasConcept C178853913 @default.
• W2104389637 hasConcept C198710026 @default.
• W2104389637 hasConcept C2777953023 @default.
• W2104389637 hasConcept C2778525890 @default.
• W2104389637 hasConcept C2779624417 @default.
• W2104389637 hasConcept C2780959883 @default.
• W2104389637 hasConcept C2991747820 @default.
• W2104389637 hasConcept C37557685 @default.
• W2104389637 hasConcept C71924100 @default.
• W2104389637 hasConcept C84393581 @default.
• W2104389637 hasConceptScore W2104389637C125567185 @default.
• W2104389637 hasConceptScore W2104389637C126322002 @default.
• W2104389637 hasConceptScore W2104389637C134018914 @default.
• W2104389637 hasConceptScore W2104389637C138976137 @default.
• W2104389637 hasConceptScore W2104389637C164705383 @default.
• W2104389637 hasConceptScore W2104389637C178853913 @default.
• W2104389637 hasConceptScore W2104389637C198710026 @default.
• W2104389637 hasConceptScore W2104389637C2777953023 @default.
• W2104389637 hasConceptScore W2104389637C2778525890 @default.
• W2104389637 hasConceptScore W2104389637C2779624417 @default.
• W2104389637 hasConceptScore W2104389637C2780959883 @default.
• W2104389637 hasConceptScore W2104389637C2991747820 @default.
• W2104389637 hasConceptScore W2104389637C37557685 @default.
• W2104389637 hasConceptScore W2104389637C71924100 @default.
• W2104389637 hasConceptScore W2104389637C84393581 @default.
• W2104389637 hasIssue "13" @default.

• next