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• W2104390622 abstract "No AccessJournal of UrologyInvestigative Urology1 Feb 1997Calcium Regulation of Urinary Bladder Function Margot S. Damaser, Kap-Byung Kim, Penelope A. Longhurst, Alan J. Wein, and Robert M. Levin Margot S. DamaserMargot S. Damaser More articles by this author , Kap-Byung KimKap-Byung Kim More articles by this author , Penelope A. LonghurstPenelope A. Longhurst More articles by this author , Alan J. WeinAlan J. Wein More articles by this author , and Robert M. LevinRobert M. Levin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65260-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To investigate the effect of independently inhibiting calcium influx from extracellular sources and calcium release from intracellular stores on the ability of the urinary bladder to generate pressure and empty. Materials and Methods: Rabbit bladders were mounted in an in vitro whole organ bath and filled with 15 ml. saline. Each bladder was incubated separately in Tyrode's solution, with diltiazem (10 micro M), to block extracellular calcium influx, or with thapsigargin (40 micro M) and ryanodine (80 micro M), to block the uptake and release of calcium from the sarcoplasmic reticulum. The bladder was then stimulated isometrically with field stimulation (32 Hz), and to empty with field stimulation and with bethanechol (250 micro M), independently. During stimulation, transmural pressure and volume emptied were measured. From these, flow rate, power, and external mechanical work were calculated. Results: In the presence of diltiazem, the time to maximal pressure decreased while the rate of pressure generation increased. This results from increased participation of intracellular calcium release, which occurs rapidly and near the smooth muscle filaments, decreasing the diffusion time. In the presence of thapsigargin and ryanodine the maximal rate of pressure generation was decreased, due to the increased diffusion time required for calcium to move to the muscle filaments from extracellular sites. Conclusions: The current study demonstrates that bladder pressure generation and emptying are dependent upon both an influx of calcium through L-type calcium channels (inhibited by diltiazem) and the stimulated release of calcium from the SR (inhibited by thapsigargin and ryanodine). References 1 : Phosphorylation of myosin light chain kinase from vascular smooth muscle by cAMP- and cGMP-dependent protein kinases. J. Mol. Cell. Cardiol.1985; 17: 841. Google Scholar 2 : Myosin light chain kinases and kinetics of myosin phosphorylation in smooth muscle cells. In: Regulation and Contraction of Smooth Muscle. Edited by . New York: A.R. Liss1987: 183. Google Scholar 3 : Calcium control of smooth muscle contractility. Am. J. Med. Sci.1988; 296: 241. 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Google Scholar Division of Urology, Department of Surgery, University of Pennsylvania School of Medicine and the Veterans Administration Medical Center, Philadelphia, Pennsylvania.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySTEIN R, HUTCHESON J, KRASNOPOLSKY L, CANNING D, CARR M and ZDERIC S (2018) THE DECOMPENSATED DETRUSOR V: MOLECULAR CORRELATES OF BLADDER FUNCTION AFTER REVERSAL OF EXPERIMENTAL OUTLET OBSTRUCTIONJournal of Urology, VOL. 166, NO. 2, (651-657), Online publication date: 1-Aug-2001.STEIN R, HUTCHESON J, GONG C, CANNING D, CARR M and ZDERIC S (2018) THE DECOMPENSATED DETRUSOR IV: EXPERIMENTAL BLADDER OUTLET OBSTRUCTION AND ITS FUNCTIONAL CORRELATION TO THE EXPRESSION OF THE RYANODINE AND VOLTAGE OPERATED CALCIUM CHANNELSJournal of Urology, VOL. 165, NO. 6 Part 2, (2284-2288), Online publication date: 1-Jun-2001.WARING J and WENDT I (2018) EFFECTS OF STREPTOZOTOCIN-INDUCED DIABETES MELLITUS ON INTRACELLULAR CALCIUM AND CONTRACTION OF LONGITUDINAL SMOOTH MUSCLE FROM RAT URINARY BLADDERJournal of Urology, VOL. 163, NO. 1, (323-330), Online publication date: 1-Jan-2000.Yu H, Levin R, Longhurst P and Damaser M (2018) Effect of Age and Outlet Resistance on Rabbit Urinary Bladder EmptyingJournal of Urology, VOL. 158, NO. 3, (924-930), Online publication date: 1-Sep-1997. Volume 157Issue 2February 1997Page: 732-738 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Margot S. Damaser More articles by this author Kap-Byung Kim More articles by this author Penelope A. Longhurst More articles by this author Alan J. Wein More articles by this author Robert M. Levin More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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