FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104391799> ?p ?o ?g. }

• W2104391799 abstract "Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease marked by both B and T cell hyperactivity which commonly affects the joints, skin, kidneys, and brain. Neuropsychiatric disease affects about 40 % of SLE patients, most frequently manifesting as depression, memory deficits, and general cognitive decline. One important and yet unresolved question is whether neuropsychiatric SLE (NPSLE) is a complication of systemic autoimmunity or whether it is primarily driven by brain-intrinsic factors. To dissect the relative contributions of the central nervous system from those of the hematopoietic compartment, we generated bone marrow chimeras between healthy control (MRL/+) and lupus-prone MRL/Tnfrsf6 lpr/lpr mice (MRL/+ → MRL/lpr), as well as control chimeras. After bone marrow reconstitution, mice underwent extensive behavioral testing, analysis of brain tissue, and histological assessment. Despite transfer of healthy MRL/+ bone marrow and marked attenuation of systemic disease, we found that MRL/+ → MRL/lpr mice had a behavioral phenotype consisting of depressive-like behavior and visuospatial memory deficits, comparable to MRL/lpr → MRL/lpr control transplanted mice and the behavioral profile previously established in MRL/lpr mice. Moreover, MRL/+ → MRL/lpr chimeric mice displayed increased brain RANTES expression, neurodegeneration, and cellular infiltration in the choroid plexus, as well as blood brain barrier disruption, all in the absence of significant systemic autoimmunity. Chimeric MRL/+ → MRL/lpr mice displayed no attenuation of the behavioral phenotype found in MRL/lpr mice, despite normalized serum autoantibodies and conserved renal function. Therefore, neuropsychiatric disease in the MRL/lpr lupus-prone strain of mice can occur absent any major contributions from systemic autoimmunity." @default.
• W2104391799 created "2016-06-24" @default.
• W2104391799 creator A5032099099 @default.
• W2104391799 creator A5061451331 @default.
• W2104391799 creator A5064419000 @default.
• W2104391799 creator A5068983560 @default.
• W2104391799 creator A5078972851 @default.
• W2104391799 creator A5088498253 @default.
• W2104391799 date "2015-11-06" @default.
• W2104391799 modified "2023-10-17" @default.
• W2104391799 title "Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL/lpr mice" @default.
• W2104391799 cites W1481551714 @default.
• W2104391799 cites W1504451986 @default.
• W2104391799 cites W1545057756 @default.
• W2104391799 cites W1569661306 @default.
• W2104391799 cites W1605213317 @default.
• W2104391799 cites W1632705158 @default.
• W2104391799 cites W1757199806 @default.
• W2104391799 cites W1919092568 @default.
• W2104391799 cites W1967936114 @default.
• W2104391799 cites W1969520387 @default.
• W2104391799 cites W1979595316 @default.
• W2104391799 cites W1979776035 @default.
• W2104391799 cites W1983203217 @default.
• W2104391799 cites W1985949580 @default.
• W2104391799 cites W1987682234 @default.
• W2104391799 cites W1993220836 @default.
• W2104391799 cites W2003346334 @default.
• W2104391799 cites W2003759043 @default.
• W2104391799 cites W2010509095 @default.
• W2104391799 cites W2012446836 @default.
• W2104391799 cites W2012692714 @default.
• W2104391799 cites W2014191884 @default.
• W2104391799 cites W2015011410 @default.
• W2104391799 cites W2020408466 @default.
• W2104391799 cites W2021014119 @default.
• W2104391799 cites W2021541291 @default.
• W2104391799 cites W2022603096 @default.
• W2104391799 cites W2022776084 @default.
• W2104391799 cites W2027406478 @default.
• W2104391799 cites W2033750371 @default.
• W2104391799 cites W2034595620 @default.
• W2104391799 cites W2041438856 @default.
• W2104391799 cites W2049676978 @default.
• W2104391799 cites W2051655508 @default.
• W2104391799 cites W2054064642 @default.
• W2104391799 cites W2055061396 @default.
• W2104391799 cites W2057407878 @default.
• W2104391799 cites W2058373538 @default.
• W2104391799 cites W2062505106 @default.
• W2104391799 cites W2063692965 @default.
• W2104391799 cites W2071646381 @default.
• W2104391799 cites W2072441360 @default.
• W2104391799 cites W2073601022 @default.
• W2104391799 cites W2077603061 @default.
• W2104391799 cites W2079230263 @default.
• W2104391799 cites W2082082257 @default.
• W2104391799 cites W2085279645 @default.
• W2104391799 cites W2091662794 @default.
• W2104391799 cites W2098809648 @default.
• W2104391799 cites W2102891732 @default.
• W2104391799 cites W2104113491 @default.
• W2104391799 cites W2118495715 @default.
• W2104391799 cites W2129037723 @default.
• W2104391799 cites W2134927393 @default.
• W2104391799 cites W2142360671 @default.
• W2104391799 cites W2148898943 @default.
• W2104391799 cites W2152255096 @default.
• W2104391799 cites W2153406260 @default.
• W2104391799 cites W2159042168 @default.
• W2104391799 cites W2164846242 @default.
• W2104391799 cites W2169352011 @default.
• W2104391799 cites W2170877210 @default.
• W2104391799 cites W2885109878 @default.
• W2104391799 cites W3022052974 @default.
• W2104391799 cites W4244503464 @default.
• W2104391799 cites W4255247890 @default.
• W2104391799 doi "https://doi.org/10.1186/s12974-015-0423-4" @default.
• W2104391799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4636802" @default.
• W2104391799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26546449" @default.
• W2104391799 hasPublicationYear "2015" @default.
• W2104391799 type Work @default.
• W2104391799 sameAs 2104391799 @default.
• W2104391799 citedByCount "43" @default.
• W2104391799 countsByYear W21043917992016 @default.
• W2104391799 countsByYear W21043917992017 @default.
• W2104391799 countsByYear W21043917992018 @default.
• W2104391799 countsByYear W21043917992019 @default.
• W2104391799 countsByYear W21043917992020 @default.
• W2104391799 countsByYear W21043917992021 @default.
• W2104391799 countsByYear W21043917992022 @default.
• W2104391799 countsByYear W21043917992023 @default.
• W2104391799 crossrefType "journal-article" @default.
• W2104391799 hasAuthorship W2104391799A5032099099 @default.
• W2104391799 hasAuthorship W2104391799A5061451331 @default.
• W2104391799 hasAuthorship W2104391799A5064419000 @default.
• W2104391799 hasAuthorship W2104391799A5068983560 @default.
• W2104391799 hasAuthorship W2104391799A5078972851 @default.
• W2104391799 hasAuthorship W2104391799A5088498253 @default.
• W2104391799 hasBestOaLocation W21043917991 @default.

• next