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- W2104392511 abstract "We have synthesized four amine-phenol ligands by condensing 2-hydroxyacetophenone with appropriate diamines and reducing the Schiff base ligands with NaBH4. The final amine-phenol ligands are a mixture of d, l and meso isomers and were used for complexation studies without any separation of the isomers. Radiochemical studies of 99mTc complexes were done at a total technetium concentration of 0.1–100 μM. Complex yields were measured by TLC, paper electrophoresis and by solvent extraction studies. 99mTc complexes were readily formed with the amine-phenol ligands, and the complexes were neutral, lipophilic and showed very good stability in aqueous solutions. Complexation studies with the imine-phenol ligands were also done. Complexes with the imine-phenol ligands formed in lower yields and were less lipophilic. Biodistribution studies of the 99mTc complexes of the amine-phenol ligands were carried out in Sprague-Dawley rats." @default.
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- W2104392511 date "1993-08-01" @default.
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- W2104392511 title "Technetium complexes of tetradentate chiral amine-phenol ligands" @default.
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- W2104392511 doi "https://doi.org/10.1016/0969-8043(93)90115-q" @default.
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