Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104393659> ?p ?o ?g. }
- W2104393659 endingPage "8797" @default.
- W2104393659 startingPage "8789" @default.
- W2104393659 abstract "Neurotrophin-3 (NT-3), its cognate receptor trkC, and voltage-gated calcium channels are coexpressed by embryonic pyramidal neurons before target contact, but their functions at this stage of development are still unclear. We show here that, in vitro, anti-NT-3 and anti-trkC antibodies blocked the increase, and NT-3 reversed the decrease in the number of calbindin-D(28k)-positive pyramidal neurons induced by, respectively, calcium channel activations and blockades. Similar results were obtained with single-neuron microcultures. In addition, voltage-gated calcium channel inhibition downregulates the extracellular levels of NT-3 in high-density cultures. Moreover, electrophysiological experiments in single-cell cultures reveal a tetrodotoxin-sensitive spontaneous electrical activity allowing voltage-gated calcium channel activation. The mouse NT-3 (-/-) mutation decreases by 40% the number of developing calbindin-D(28k)-positive pyramidal neurons, without affecting neuronal survival, both in vitro and in vivo. Thus, present results strongly support that an activity-dependent autocrine NT-3 loop provides a local, intrinsic mechanism by which, before target contact, hippocampal pyramidal-like neurons may regulate their own differentiation, a role that may be important during early CNS differentiation or after adult target disruption." @default.
- W2104393659 created "2016-06-24" @default.
- W2104393659 creator A5015101274 @default.
- W2104393659 creator A5018887663 @default.
- W2104393659 creator A5077501619 @default.
- W2104393659 creator A5091246104 @default.
- W2104393659 date "2001-11-15" @default.
- W2104393659 modified "2023-10-17" @default.
- W2104393659 title "An Activity-Dependent Neurotrophin-3 Autocrine Loop Regulates the Phenotype of Developing Hippocampal Pyramidal Neurons before Target Contact" @default.
- W2104393659 cites W1516264649 @default.
- W2104393659 cites W1532382772 @default.
- W2104393659 cites W1596931775 @default.
- W2104393659 cites W1644418226 @default.
- W2104393659 cites W1655701149 @default.
- W2104393659 cites W1661938295 @default.
- W2104393659 cites W1664741673 @default.
- W2104393659 cites W1770338643 @default.
- W2104393659 cites W1891880696 @default.
- W2104393659 cites W1963806203 @default.
- W2104393659 cites W1964441774 @default.
- W2104393659 cites W1966367605 @default.
- W2104393659 cites W1969634414 @default.
- W2104393659 cites W1979896676 @default.
- W2104393659 cites W1987628941 @default.
- W2104393659 cites W1987700551 @default.
- W2104393659 cites W1991564793 @default.
- W2104393659 cites W1992171678 @default.
- W2104393659 cites W2000304313 @default.
- W2104393659 cites W2000540402 @default.
- W2104393659 cites W2003303549 @default.
- W2104393659 cites W2007261940 @default.
- W2104393659 cites W2007890001 @default.
- W2104393659 cites W2011663144 @default.
- W2104393659 cites W2019864299 @default.
- W2104393659 cites W2027377352 @default.
- W2104393659 cites W2034137241 @default.
- W2104393659 cites W2038073702 @default.
- W2104393659 cites W2041919003 @default.
- W2104393659 cites W2042753272 @default.
- W2104393659 cites W2051600135 @default.
- W2104393659 cites W2055027675 @default.
- W2104393659 cites W2055979394 @default.
- W2104393659 cites W2061209445 @default.
- W2104393659 cites W2065493307 @default.
- W2104393659 cites W2068118161 @default.
- W2104393659 cites W2068629598 @default.
- W2104393659 cites W2069527370 @default.
- W2104393659 cites W2069960987 @default.
- W2104393659 cites W2071582516 @default.
- W2104393659 cites W2078316783 @default.
- W2104393659 cites W2089309198 @default.
- W2104393659 cites W2089454493 @default.
- W2104393659 cites W2090429702 @default.
- W2104393659 cites W2101808673 @default.
- W2104393659 cites W2111439846 @default.
- W2104393659 cites W2114216374 @default.
- W2104393659 cites W2122879138 @default.
- W2104393659 cites W2134029687 @default.
- W2104393659 cites W2134678910 @default.
- W2104393659 cites W2142367626 @default.
- W2104393659 cites W2144126683 @default.
- W2104393659 cites W2156945415 @default.
- W2104393659 cites W2164591831 @default.
- W2104393659 cites W2170547714 @default.
- W2104393659 cites W4317929652 @default.
- W2104393659 doi "https://doi.org/10.1523/jneurosci.21-22-08789.2001" @default.
- W2104393659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6762280" @default.
- W2104393659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11698591" @default.
- W2104393659 hasPublicationYear "2001" @default.
- W2104393659 type Work @default.
- W2104393659 sameAs 2104393659 @default.
- W2104393659 citedByCount "29" @default.
- W2104393659 countsByYear W21043936592012 @default.
- W2104393659 countsByYear W21043936592013 @default.
- W2104393659 countsByYear W21043936592014 @default.
- W2104393659 countsByYear W21043936592016 @default.
- W2104393659 countsByYear W21043936592020 @default.
- W2104393659 countsByYear W21043936592023 @default.
- W2104393659 crossrefType "journal-article" @default.
- W2104393659 hasAuthorship W2104393659A5015101274 @default.
- W2104393659 hasAuthorship W2104393659A5018887663 @default.
- W2104393659 hasAuthorship W2104393659A5077501619 @default.
- W2104393659 hasAuthorship W2104393659A5091246104 @default.
- W2104393659 hasBestOaLocation W21043936591 @default.
- W2104393659 hasConcept C126322002 @default.
- W2104393659 hasConcept C148762608 @default.
- W2104393659 hasConcept C160539049 @default.
- W2104393659 hasConcept C169760540 @default.
- W2104393659 hasConcept C170493617 @default.
- W2104393659 hasConcept C18699975 @default.
- W2104393659 hasConcept C203014093 @default.
- W2104393659 hasConcept C204232928 @default.
- W2104393659 hasConcept C26265296 @default.
- W2104393659 hasConcept C2778437258 @default.
- W2104393659 hasConcept C2778790584 @default.
- W2104393659 hasConcept C2779456298 @default.
- W2104393659 hasConcept C37088560 @default.
- W2104393659 hasConcept C50254741 @default.