Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104393896> ?p ?o ?g. }
- W2104393896 endingPage "1243" @default.
- W2104393896 startingPage "1231" @default.
- W2104393896 abstract "High-risk neuroblastoma is a severe pediatric tumor characterized by poor prognosis. Understanding the molecular mechanisms involved in tumor development and progression is strategic for the improvement of pharmacological therapies. Notch was recently proposed as a pharmacological target for the therapy of several cancers and is emerging as a new neuroblastoma-related molecular pathway. However, the precise role played by Notch in this cancer remains to be studied extensively. Here, we show that Notch activation by the Jagged1 ligand enhances the proliferation of neuroblastoma cells, and we propose the possible use of Notch-blocking γ-secretase inhibitors (GSIs) in neuroblastoma therapy. Two different GSIs, Compound E and DAPT, were tested alone or in combination with 13-cis retinoic acid (RA) on neuroblastoma cell lines. SH-SY5Y and IMR-32 cells were chosen as paradigms of lower and higher malignancy, respectively. Used alone, GSIs induced complete cell growth arrest, promoted neuronal differentiation, and significantly reduced cell motility. The combination of GSIs and 13-cis RA resulted in the enhanced growth inhibition, differentiation, and migration of neuroblastoma cells. In summary, our data suggest that a combination of GSIs with 13-cis RA offers a therapeutic advantage over a single agent, indicating a potential novel therapy for neuroblastoma." @default.
- W2104393896 created "2016-06-24" @default.
- W2104393896 creator A5010932720 @default.
- W2104393896 creator A5053089505 @default.
- W2104393896 creator A5062998305 @default.
- W2104393896 creator A5067585947 @default.
- W2104393896 creator A5074986039 @default.
- W2104393896 creator A5078826164 @default.
- W2104393896 creator A5079505297 @default.
- W2104393896 creator A5087815357 @default.
- W2104393896 date "2010-08-17" @default.
- W2104393896 modified "2023-10-16" @default.
- W2104393896 title "Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells" @default.
- W2104393896 cites W1548390588 @default.
- W2104393896 cites W1969951398 @default.
- W2104393896 cites W1975255784 @default.
- W2104393896 cites W1975418841 @default.
- W2104393896 cites W1977962361 @default.
- W2104393896 cites W1979254220 @default.
- W2104393896 cites W1981788720 @default.
- W2104393896 cites W1982023788 @default.
- W2104393896 cites W1984059331 @default.
- W2104393896 cites W1984295575 @default.
- W2104393896 cites W1985657116 @default.
- W2104393896 cites W1986157775 @default.
- W2104393896 cites W2001957066 @default.
- W2104393896 cites W2009434997 @default.
- W2104393896 cites W2012960629 @default.
- W2104393896 cites W2014311774 @default.
- W2104393896 cites W2019399041 @default.
- W2104393896 cites W2022054181 @default.
- W2104393896 cites W2029470195 @default.
- W2104393896 cites W2035396934 @default.
- W2104393896 cites W2049243908 @default.
- W2104393896 cites W2053910911 @default.
- W2104393896 cites W2054001958 @default.
- W2104393896 cites W2055201556 @default.
- W2104393896 cites W2055366515 @default.
- W2104393896 cites W2057421005 @default.
- W2104393896 cites W2062069005 @default.
- W2104393896 cites W2067606868 @default.
- W2104393896 cites W2068181025 @default.
- W2104393896 cites W2069907057 @default.
- W2104393896 cites W2089083658 @default.
- W2104393896 cites W2090338864 @default.
- W2104393896 cites W2096316414 @default.
- W2104393896 cites W2096442515 @default.
- W2104393896 cites W2098189424 @default.
- W2104393896 cites W2103694596 @default.
- W2104393896 cites W2103935212 @default.
- W2104393896 cites W2104081788 @default.
- W2104393896 cites W2109368503 @default.
- W2104393896 cites W2119937633 @default.
- W2104393896 cites W2127500065 @default.
- W2104393896 cites W2129636032 @default.
- W2104393896 cites W2130470865 @default.
- W2104393896 cites W2133126220 @default.
- W2104393896 cites W2137290278 @default.
- W2104393896 cites W2140909771 @default.
- W2104393896 cites W2146953254 @default.
- W2104393896 cites W2156055427 @default.
- W2104393896 cites W2157930949 @default.
- W2104393896 cites W2169075111 @default.
- W2104393896 cites W22223414 @default.
- W2104393896 cites W2320865101 @default.
- W2104393896 cites W2327522594 @default.
- W2104393896 cites W4211031423 @default.
- W2104393896 doi "https://doi.org/10.1093/neuonc/noq101" @default.
- W2104393896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3018939" @default.
- W2104393896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20716592" @default.
- W2104393896 hasPublicationYear "2010" @default.
- W2104393896 type Work @default.
- W2104393896 sameAs 2104393896 @default.
- W2104393896 citedByCount "41" @default.
- W2104393896 countsByYear W21043938962012 @default.
- W2104393896 countsByYear W21043938962013 @default.
- W2104393896 countsByYear W21043938962015 @default.
- W2104393896 countsByYear W21043938962016 @default.
- W2104393896 countsByYear W21043938962017 @default.
- W2104393896 countsByYear W21043938962018 @default.
- W2104393896 countsByYear W21043938962019 @default.
- W2104393896 countsByYear W21043938962020 @default.
- W2104393896 countsByYear W21043938962021 @default.
- W2104393896 countsByYear W21043938962022 @default.
- W2104393896 countsByYear W21043938962023 @default.
- W2104393896 crossrefType "journal-article" @default.
- W2104393896 hasAuthorship W2104393896A5010932720 @default.
- W2104393896 hasAuthorship W2104393896A5053089505 @default.
- W2104393896 hasAuthorship W2104393896A5062998305 @default.
- W2104393896 hasAuthorship W2104393896A5067585947 @default.
- W2104393896 hasAuthorship W2104393896A5074986039 @default.
- W2104393896 hasAuthorship W2104393896A5078826164 @default.
- W2104393896 hasAuthorship W2104393896A5079505297 @default.
- W2104393896 hasAuthorship W2104393896A5087815357 @default.
- W2104393896 hasBestOaLocation W21043938961 @default.
- W2104393896 hasConcept C126322002 @default.
- W2104393896 hasConcept C161879069 @default.
- W2104393896 hasConcept C2776601000 @default.