FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104408712> ?p ?o ?g. }

• W2104408712 endingPage "1375" @default.
• W2104408712 startingPage "1365" @default.
• W2104408712 abstract "Abstract Background: The administration of salbutamol is permitted only by inhalation by the International Olympic Committee (IOC) for the management of asthma and exercise-induced asthma in athletes. The establishment of criteria to distinguish between the IOC authorized use (inhaled) and the IOC prohibited use (oral) of salbutamol appeared possible using simultaneous evaluation of variables based on the concentration of nonconjugated enantiomers of salbutamol excreted in urine. Methods: Urine was collected from asthmatic and nonasthmatic swimmers who had received various preexercise doses of oral (five doses of 4 mg) or inhaled (two doses of 100 μg) salbutamol. Urine was also obtained from subjects who had received the maximum dosage of inhaled salbutamol advisable for competing athletes to provide protection from exercise-induced asthma and treatment of asthma (1600 μg in 24 h, 800 μg being in the last 4 h). All samples were analyzed to determine the total amount of unchanged salbutamol excreted in urine and the ratio between the S and R enantiomers. Results: The discriminant function D = −3.776 + 1.46 × 10−3 {[S(+)] + [R(−)]} + 1.012 {[S(+)]/[R(−)]} can be used to classify data into two groups, inhaled and oral. The confirmatory criterion suggested (cutoff at D = 1.06, 4 SD from the mean D value of the inhaled distribution) has been verified in different sets of samples showing suspicious concentrations by conventional screening procedures in doping control. An 11.8% false-negative (oral classified as inhaled) rate is assumed with the confirmatory criterion proposed, but virtually no false positives (inhaled classified as oral) are obtained (&lt;1 in 33 000). Conclusions: The overall procedure recommended is to screen all samples and to apply the confirmation criterion proposed to samples showing free racemic salbutamol concentrations &gt;500 μg/L by gas chromatography-mass spectrometry or free + conjugated racemic salbutamol concentrations &gt;1400 μg/L by ELISA." @default.
• W2104408712 created "2016-06-24" @default.
• W2104408712 creator A5022761489 @default.
• W2104408712 creator A5025398873 @default.
• W2104408712 creator A5025915740 @default.
• W2104408712 creator A5033049869 @default.
• W2104408712 creator A5033539160 @default.
• W2104408712 creator A5038134435 @default.
• W2104408712 creator A5054939632 @default.
• W2104408712 creator A5069775668 @default.
• W2104408712 date "2000-09-01" @default.
• W2104408712 modified "2023-09-22" @default.
• W2104408712 title "Discrimination of Prohibited Oral Use of Salbutamol from Authorized Inhaled Asthma Treatment" @default.
• W2104408712 cites W1523155803 @default.
• W2104408712 cites W19162607 @default.
• W2104408712 cites W1996537915 @default.
• W2104408712 cites W2001041699 @default.
• W2104408712 cites W2001555726 @default.
• W2104408712 cites W2006545949 @default.
• W2104408712 cites W2012327969 @default.
• W2104408712 cites W2012400732 @default.
• W2104408712 cites W2015500397 @default.
• W2104408712 cites W2021133894 @default.
• W2104408712 cites W2039252335 @default.
• W2104408712 cites W2039801344 @default.
• W2104408712 cites W2046272179 @default.
• W2104408712 cites W2071149906 @default.
• W2104408712 cites W2082268320 @default.
• W2104408712 cites W2105266904 @default.
• W2104408712 cites W2161397208 @default.
• W2104408712 cites W2170035880 @default.
• W2104408712 cites W4238585271 @default.
• W2104408712 doi "https://doi.org/10.1093/clinchem/46.9.1365" @default.
• W2104408712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10973867" @default.
• W2104408712 hasPublicationYear "2000" @default.
• W2104408712 type Work @default.
• W2104408712 sameAs 2104408712 @default.
• W2104408712 citedByCount "61" @default.
• W2104408712 countsByYear W21044087122012 @default.
• W2104408712 countsByYear W21044087122013 @default.
• W2104408712 countsByYear W21044087122014 @default.
• W2104408712 countsByYear W21044087122015 @default.
• W2104408712 countsByYear W21044087122016 @default.
• W2104408712 countsByYear W21044087122017 @default.
• W2104408712 countsByYear W21044087122018 @default.
• W2104408712 countsByYear W21044087122019 @default.
• W2104408712 countsByYear W21044087122021 @default.
• W2104408712 countsByYear W21044087122022 @default.
• W2104408712 countsByYear W21044087122023 @default.
• W2104408712 crossrefType "journal-article" @default.
• W2104408712 hasAuthorship W2104408712A5022761489 @default.
• W2104408712 hasAuthorship W2104408712A5025398873 @default.
• W2104408712 hasAuthorship W2104408712A5025915740 @default.
• W2104408712 hasAuthorship W2104408712A5033049869 @default.
• W2104408712 hasAuthorship W2104408712A5033539160 @default.
• W2104408712 hasAuthorship W2104408712A5038134435 @default.
• W2104408712 hasAuthorship W2104408712A5054939632 @default.
• W2104408712 hasAuthorship W2104408712A5069775668 @default.
• W2104408712 hasBestOaLocation W21044087121 @default.
• W2104408712 hasConcept C126322002 @default.
• W2104408712 hasConcept C2776042228 @default.
• W2104408712 hasConcept C2776954882 @default.
• W2104408712 hasConcept C2777394947 @default.
• W2104408712 hasConcept C2780026642 @default.
• W2104408712 hasConcept C42219234 @default.
• W2104408712 hasConcept C71924100 @default.
• W2104408712 hasConceptScore W2104408712C126322002 @default.
• W2104408712 hasConceptScore W2104408712C2776042228 @default.
• W2104408712 hasConceptScore W2104408712C2776954882 @default.
• W2104408712 hasConceptScore W2104408712C2777394947 @default.
• W2104408712 hasConceptScore W2104408712C2780026642 @default.
• W2104408712 hasConceptScore W2104408712C42219234 @default.
• W2104408712 hasConceptScore W2104408712C71924100 @default.
• W2104408712 hasIssue "9" @default.
• W2104408712 hasLocation W21044087121 @default.
• W2104408712 hasLocation W21044087122 @default.
• W2104408712 hasOpenAccess W2104408712 @default.
• W2104408712 hasPrimaryLocation W21044087121 @default.
• W2104408712 hasRelatedWork W131230462 @default.
• W2104408712 hasRelatedWork W1969317349 @default.
• W2104408712 hasRelatedWork W2055365947 @default.
• W2104408712 hasRelatedWork W2163077293 @default.
• W2104408712 hasRelatedWork W2362920737 @default.
• W2104408712 hasRelatedWork W2393562478 @default.
• W2104408712 hasRelatedWork W2411760952 @default.
• W2104408712 hasRelatedWork W2469966616 @default.
• W2104408712 hasRelatedWork W2523349609 @default.
• W2104408712 hasRelatedWork W2562223226 @default.
• W2104408712 hasVolume "46" @default.
• W2104408712 isParatext "false" @default.
• W2104408712 isRetracted "false" @default.
• W2104408712 magId "2104408712" @default.
• W2104408712 workType "article" @default.