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• W2104409603 abstract "Abstract Aim To evaluate differences in uteroplacental blood flow and pregnancy outcome in women with idiopathic recurrent spontaneous miscarriage ( IRSM ) following administration of micronized vaginal progesterone and oral dydrogesterone. Methods One hundred and thirty‐three women (aged 23–40 years) who had had early miscarriages and spontaneous conception participated. Oral dydrogesterone (group A , n = 51) and micronized vaginal progesterone (group B , n = 50) were administrated for luteal support and compared. Pregnant women without history of recurrent miscarriage served as controls (group C , n = 32). The outcome measures consisted of endometrial blood flow parameters by Doppler indices and ongoing pregnancy rate. Results Before progesterone supplementation, resistivity index ( RI ) and pulsatility index ( PI ) were found to be significantly higher in groups A and B as compared to controls. Although statistically not significant, end diastolic velocity ( EDV ) and systolic/diastolic ( S / D ) ratio was found to be superior in controls than IRSM women. Peak systolic velocity ( PSV ) was comparable between IRSM and non‐ IRSM groups. Following progesterone supplementation, groups A and B showed a highly significant reduction in RI , PI and an increase in EDV . A relative increase in the value of PSV was observed in group A as compared to group B . There was remarkable difference in S / D in both groups. Although not statistically significant, group C showed reduction in RI , PI , PSV , EDV and S / D ratio. Pregnancy salvage rates were higher in group A (92.0%) as compared to group B (82.3%). Conclusion Progesterone supplementation appears to lower vascular resistance in women with IRSM . Oral dydrogesterone appears to be equally effective in improving endometrial blood flow as compared with micronized progesterone." @default.
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• W2104409603 date "2014-07-01" @default.
• W2104409603 modified "2023-10-03" @default.
• W2104409603 title "Assessment of sub-endometrial blood flow parameters following dydrogesterone and micronized vaginal progesterone administration in women with idiopathic recurrent miscarriage: A pilot study" @default.
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• W2104409603 doi "https://doi.org/10.1111/jog.12456" @default.
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