FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104416984> ?p ?o ?g. }

• W2104416984 endingPage "884" @default.
• W2104416984 startingPage "879" @default.
• W2104416984 abstract "Background— Prospective epidemiological studies have shown that low plasma levels of HDL cholesterol (HDL-C) are associated with an increased risk for cardiovascular disease (CVD). Despite nearly 40 years of research, however, it is unclear whether this also holds true for individuals with severely reduced levels of HDL-C due to mutations in the lecithin:cholesterol acyltransferase ( LCAT ) gene. Better insight into CVD risk in these individuals may provide clues toward the potential of LCAT as a pharmaceutical target to raise HDL-C levels. Methods and Results— Lipids, lipoproteins, high-sensitivity C-reactive protein (CRP), and carotid artery intima-media thickness (IMT) were assessed in 47 heterozygotes for LCAT gene mutations and 58 family controls. Compared with controls, heterozygotes presented with a mean 36% decrease in HDL-C levels ( P <0.0001), a 23% increase in triglyceride levels ( P <0.0001), and a 2.1-fold increase in CRP levels ( P <0.0001). Mean carotid IMT was significantly increased in heterozygotes compared with family controls (0.623±0.13 versus 0.591±0.08 mm). After adjustment for age, gender, and alcohol use, this difference proved statistically significant ( P <0.0015). Conclusions— The data show that heterozygosity for LCAT gene defects is associated with low HDL-C levels and elevated concentration of triglycerides and CRP in plasma. This phenotype underlies increased IMT in carriers versus controls, which suggests that LCAT protects against atherosclerosis. This in turn indicates that targeting LCAT to raise HDL-C may reduce CVD risk." @default.
• W2104416984 created "2016-06-24" @default.
• W2104416984 creator A5004099465 @default.
• W2104416984 creator A5013598309 @default.
• W2104416984 creator A5015459043 @default.
• W2104416984 creator A5051056050 @default.
• W2104416984 creator A5056369468 @default.
• W2104416984 creator A5062651514 @default.
• W2104416984 creator A5072544302 @default.
• W2104416984 creator A5073506012 @default.
• W2104416984 creator A5077848934 @default.
• W2104416984 creator A5091785733 @default.
• W2104416984 date "2005-08-09" @default.
• W2104416984 modified "2023-10-15" @default.
• W2104416984 title "Compromised LCAT Function Is Associated With Increased Atherosclerosis" @default.
• W2104416984 cites W1949306762 @default.
• W2104416984 cites W1993764201 @default.
• W2104416984 cites W1995123501 @default.
• W2104416984 cites W2008418637 @default.
• W2104416984 cites W2022320294 @default.
• W2104416984 cites W2024529248 @default.
• W2104416984 cites W2029841039 @default.
• W2104416984 cites W2030428938 @default.
• W2104416984 cites W2042602450 @default.
• W2104416984 cites W2043278353 @default.
• W2104416984 cites W2044590548 @default.
• W2104416984 cites W2054497136 @default.
• W2104416984 cites W2054816749 @default.
• W2104416984 cites W2058610272 @default.
• W2104416984 cites W2070985940 @default.
• W2104416984 cites W2076177085 @default.
• W2104416984 cites W2077099366 @default.
• W2104416984 cites W2079633354 @default.
• W2104416984 cites W2083806897 @default.
• W2104416984 cites W2086621928 @default.
• W2104416984 cites W2086722016 @default.
• W2104416984 cites W2093648180 @default.
• W2104416984 cites W2095507444 @default.
• W2104416984 cites W2097583089 @default.
• W2104416984 cites W2103965138 @default.
• W2104416984 cites W2110695197 @default.
• W2104416984 cites W2113504642 @default.
• W2104416984 cites W2115935785 @default.
• W2104416984 cites W2116404316 @default.
• W2104416984 cites W2117416880 @default.
• W2104416984 cites W2121714459 @default.
• W2104416984 cites W2125991409 @default.
• W2104416984 cites W2129788418 @default.
• W2104416984 cites W2131620609 @default.
• W2104416984 cites W2134651226 @default.
• W2104416984 cites W2137188051 @default.
• W2104416984 cites W2138386247 @default.
• W2104416984 cites W2148563579 @default.
• W2104416984 cites W2162922521 @default.
• W2104416984 doi "https://doi.org/10.1161/circulationaha.105.540427" @default.
• W2104416984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16061733" @default.
• W2104416984 hasPublicationYear "2005" @default.
• W2104416984 type Work @default.
• W2104416984 sameAs 2104416984 @default.
• W2104416984 citedByCount "156" @default.
• W2104416984 countsByYear W21044169842012 @default.
• W2104416984 countsByYear W21044169842013 @default.
• W2104416984 countsByYear W21044169842014 @default.
• W2104416984 countsByYear W21044169842015 @default.
• W2104416984 countsByYear W21044169842016 @default.
• W2104416984 countsByYear W21044169842017 @default.
• W2104416984 countsByYear W21044169842018 @default.
• W2104416984 countsByYear W21044169842019 @default.
• W2104416984 countsByYear W21044169842020 @default.
• W2104416984 countsByYear W21044169842021 @default.
• W2104416984 countsByYear W21044169842022 @default.
• W2104416984 countsByYear W21044169842023 @default.
• W2104416984 crossrefType "journal-article" @default.
• W2104416984 hasAuthorship W2104416984A5004099465 @default.
• W2104416984 hasAuthorship W2104416984A5013598309 @default.
• W2104416984 hasAuthorship W2104416984A5015459043 @default.
• W2104416984 hasAuthorship W2104416984A5051056050 @default.
• W2104416984 hasAuthorship W2104416984A5056369468 @default.
• W2104416984 hasAuthorship W2104416984A5062651514 @default.
• W2104416984 hasAuthorship W2104416984A5072544302 @default.
• W2104416984 hasAuthorship W2104416984A5073506012 @default.
• W2104416984 hasAuthorship W2104416984A5077848934 @default.
• W2104416984 hasAuthorship W2104416984A5091785733 @default.
• W2104416984 hasBestOaLocation W21044169841 @default.
• W2104416984 hasConcept C104317684 @default.
• W2104416984 hasConcept C126322002 @default.
• W2104416984 hasConcept C134018914 @default.
• W2104416984 hasConcept C153471976 @default.
• W2104416984 hasConcept C180754005 @default.
• W2104416984 hasConcept C2778163477 @default.
• W2104416984 hasConcept C2778913445 @default.
• W2104416984 hasConcept C2779564620 @default.
• W2104416984 hasConcept C2780072125 @default.
• W2104416984 hasConcept C37002583 @default.
• W2104416984 hasConcept C54355233 @default.
• W2104416984 hasConcept C55493867 @default.
• W2104416984 hasConcept C62746215 @default.
• W2104416984 hasConcept C71924100 @default.

• next