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• W2104421773 abstract "No AccessJournal of UrologyAdult Urology1 Mar 2012Long-Term Impact of Arsenic in Drinking Water on Bladder Cancer Health Care and Mortality Rates 20 Years After End of Exposure Mario I. Fernández, J. Francisco López, Bruno Vivaldi, and Fernando Coz Mario I. FernándezMario I. Fernández Department of Urology, Hospital Militar, Santiago de Chile, Chile Department of Urology, Clínica Alemana, Santiago de Chile, Chile More articles by this author , J. Francisco LópezJ. Francisco López Department of Urology, Hospital Militar, Santiago de Chile, Chile Faculty of Medicine, Universidad de Los Andes, Santiago de Chile, Chile More articles by this author , Bruno VivaldiBruno Vivaldi Department of Urology, Hospital Militar, Santiago de Chile, Chile Faculty of Medicine, Universidad de Los Andes, Santiago de Chile, Chile More articles by this author , and Fernando CozFernando Coz Department of Urology, Hospital Militar, Santiago de Chile, Chile Faculty of Medicine, Universidad de Los Andes, Santiago de Chile, Chile More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.10.157AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In this study we assessed bladder cancer health care and mortality trends in recent decades in a well studied arsenic exposed area in Northern Chile. Materials and Methods: Arsenic levels in the affected region were obtained for the last 60 years, and correlated with bladder cancer hospital discharge and mortality rates in recent decades. Results: Bladder cancer hospital discharge rates were significantly higher in the affected region (peak RR 3.6, 95% CI 3.0–4.7). Mortality rates for bladder cancer showed a trend of increase during the period analyzed, reaching peak mortality rates of 28.4 per 100,000 for men and 18.7 per 100,000 for women in the last 10 years. Poisson regression models showed an increased mortality risk in the studied region compared to the rest of the country until the present for men (IRR 5.3, 95% CI 4.8–5.8) and women (IRR 7.8, 95% CI 7.0–8.7). Mean age at cancer specific death was significantly lower in the exposed region (69.6 years, 95% CI 68.4–70.7 vs 73.7 years, 95% CI 73.3–74.2, p <0.01). Conclusions: Exposure to arsenic is related to a significant need for bladder cancer health care and to high mortality rates even 20 years after having controlled arsenic levels in drinking water. Affected individuals should be aware of the significant impact of this ecological factor. Further research is required to identify strategies for the management of bladder cancer in arsenic exposed populations. References 1 : Environmental factors and genetic susceptibility promote urinary bladder cancer. Toxicol Lett2010; 193: 131. Google Scholar 2 : Arsenic exposure and its impact on health in Chile. J Health Popul Nutr2006; 24: 164. Google Scholar 3 : Estimate of the current exposure of the urban population of northern Chile to arsenic. In: Interdisciplinary Perspectives on Drinking Water Risk Assessment and Management. Edited by . Wallingford, UK: IAHS Press2000: 3. 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Accessed November 29, 2011. Google Scholar 29 : Quality of mortality statistics in Chile, 1997-2003. Rev Med Chil2006; 134: 1191. Google Scholar 30 : Evaluation of data quality in the cancer registry: principles and methods: Part I: comparability, validity and timeliness. Eur J Cancer2009; 45: 747. Google Scholar © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byAtala A (2018) Re: Dietary Sources of N-Nitroso Compounds and Bladder Cancer Risk: Findings from the Los Angeles Bladder Cancer StudyJournal of Urology, VOL. 192, NO. 2, (614-615), Online publication date: 1-Aug-2014. Volume 187Issue 3March 2012Page: 856-861 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.Keywordsenvironmentalcarcinogensarsenicurinary bladder neoplasmsMetricsAuthor Information Mario I. Fernández Department of Urology, Hospital Militar, Santiago de Chile, Chile Department of Urology, Clínica Alemana, Santiago de Chile, Chile More articles by this author J. Francisco López Department of Urology, Hospital Militar, Santiago de Chile, Chile Faculty of Medicine, Universidad de Los Andes, Santiago de Chile, Chile More articles by this author Bruno Vivaldi Department of Urology, Hospital Militar, Santiago de Chile, Chile Faculty of Medicine, Universidad de Los Andes, Santiago de Chile, Chile More articles by this author Fernando Coz Department of Urology, Hospital Militar, Santiago de Chile, Chile Faculty of Medicine, Universidad de Los Andes, Santiago de Chile, Chile More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2104421773 title "Long-Term Impact of Arsenic in Drinking Water on Bladder Cancer Health Care and Mortality Rates 20 Years After End of Exposure" @default.
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