Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104423611> ?p ?o ?g. }
- W2104423611 endingPage "1027" @default.
- W2104423611 startingPage "1007" @default.
- W2104423611 abstract "Methadone is the major opioid substitution therapy for opioid dependence. Dosage is highly variable and is often controlled by the patient and prescriber according to local and national policy and guidelines. Nevertheless many genetic factors have been investigated including those affecting its metabolism (CYP2B6-consistent results), efflux transport (P-gp-inconsistent results), target μ-opioid receptor (μ-opioid receptor-inconsistent results) and a host of other receptors (DRD2) and signaling elements (GIRK2 and ARRB2; not replicated). None by themselves have been able to substantially explain dosage variation (the major but not sole end point). When multiple genes have been combined such as ABCB1, CYP2B6, OPRM1 and DRD2 a greater contribution to dosage variation was found but not as yet replicated. As stabilization of dosage needs to be made rapidly, it is imperative that larger internationally based studies be instigated so that genetic contribution to dosage can be properly assessed, which may or may not tailor to different ethnic groups and each country’s policy towards an outcome that benefits all." @default.
- W2104423611 created "2016-06-24" @default.
- W2104423611 creator A5032460662 @default.
- W2104423611 creator A5046046009 @default.
- W2104423611 creator A5077900083 @default.
- W2104423611 creator A5089827696 @default.
- W2104423611 date "2014-05-01" @default.
- W2104423611 modified "2023-10-01" @default.
- W2104423611 title "Pharmacogenomics of methadone maintenance treatment" @default.
- W2104423611 cites W1494031902 @default.
- W2104423611 cites W1497037168 @default.
- W2104423611 cites W1565736591 @default.
- W2104423611 cites W190262706 @default.
- W2104423611 cites W1967351866 @default.
- W2104423611 cites W1969620637 @default.
- W2104423611 cites W1971140635 @default.
- W2104423611 cites W1975104561 @default.
- W2104423611 cites W1975481605 @default.
- W2104423611 cites W1976960945 @default.
- W2104423611 cites W1977830653 @default.
- W2104423611 cites W1978628771 @default.
- W2104423611 cites W1979555187 @default.
- W2104423611 cites W1980462575 @default.
- W2104423611 cites W1981644593 @default.
- W2104423611 cites W1982476232 @default.
- W2104423611 cites W1983610014 @default.
- W2104423611 cites W1984744701 @default.
- W2104423611 cites W1986653661 @default.
- W2104423611 cites W1987178620 @default.
- W2104423611 cites W1988646111 @default.
- W2104423611 cites W1989254187 @default.
- W2104423611 cites W1989438200 @default.
- W2104423611 cites W1992009633 @default.
- W2104423611 cites W1992553889 @default.
- W2104423611 cites W1994400379 @default.
- W2104423611 cites W1996104441 @default.
- W2104423611 cites W1996783118 @default.
- W2104423611 cites W1998425896 @default.
- W2104423611 cites W1999190513 @default.
- W2104423611 cites W2002889837 @default.
- W2104423611 cites W2003049082 @default.
- W2104423611 cites W2005448974 @default.
- W2104423611 cites W2008825099 @default.
- W2104423611 cites W2008880324 @default.
- W2104423611 cites W2012743573 @default.
- W2104423611 cites W2015937282 @default.
- W2104423611 cites W2016485321 @default.
- W2104423611 cites W2019528567 @default.
- W2104423611 cites W2019695588 @default.
- W2104423611 cites W2019939029 @default.
- W2104423611 cites W2022824877 @default.
- W2104423611 cites W2023090750 @default.
- W2104423611 cites W2024812185 @default.
- W2104423611 cites W2031248731 @default.
- W2104423611 cites W2032047115 @default.
- W2104423611 cites W2032191165 @default.
- W2104423611 cites W2032781032 @default.
- W2104423611 cites W2034008127 @default.
- W2104423611 cites W2034150627 @default.
- W2104423611 cites W2044746762 @default.
- W2104423611 cites W2044951617 @default.
- W2104423611 cites W2045602669 @default.
- W2104423611 cites W2048536578 @default.
- W2104423611 cites W2049949564 @default.
- W2104423611 cites W2049962267 @default.
- W2104423611 cites W2051175627 @default.
- W2104423611 cites W2052534989 @default.
- W2104423611 cites W2053466984 @default.
- W2104423611 cites W2054129577 @default.
- W2104423611 cites W2055927684 @default.
- W2104423611 cites W2058864686 @default.
- W2104423611 cites W2062305479 @default.
- W2104423611 cites W2063516995 @default.
- W2104423611 cites W2063836800 @default.
- W2104423611 cites W2064701493 @default.
- W2104423611 cites W2068865770 @default.
- W2104423611 cites W2069249816 @default.
- W2104423611 cites W2070440937 @default.
- W2104423611 cites W2073289289 @default.
- W2104423611 cites W2080822069 @default.
- W2104423611 cites W2081577644 @default.
- W2104423611 cites W2082900632 @default.
- W2104423611 cites W2086774100 @default.
- W2104423611 cites W2087605890 @default.
- W2104423611 cites W2090253646 @default.
- W2104423611 cites W2099841550 @default.
- W2104423611 cites W2106294378 @default.
- W2104423611 cites W2107464754 @default.
- W2104423611 cites W2107948836 @default.
- W2104423611 cites W2109443151 @default.
- W2104423611 cites W2111652219 @default.
- W2104423611 cites W2115239219 @default.
- W2104423611 cites W2117785206 @default.
- W2104423611 cites W2123175858 @default.
- W2104423611 cites W2124356176 @default.
- W2104423611 cites W2124563076 @default.
- W2104423611 cites W2125202254 @default.
- W2104423611 cites W2125943141 @default.