FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104427304> ?p ?o ?g. }

• W2104427304 endingPage "L717" @default.
• W2104427304 startingPage "L710" @default.
• W2104427304 abstract "Perinatal exposure to maternal smoke is associated with adverse pulmonary effects, including reduced lung function and increased incidence of asthma. However, the mechanisms underlying these effects are unknown, and there is no effective preventive and/or therapeutic intervention. Recently, we suggested that downregulation of homeostatic mesenchymal peroxisome proliferator-activated receptor-γ (PPARγ) signaling following in utero nicotine exposure might contribute to chronic lung diseases such as asthma. We used an in vivo rat model to determine the effect of perinatal nicotine exposure on 1) offspring pulmonary function, 2) mesenchymal markers of airway contractility in trachea and lung tissue, and 3) whether administration of a PPARγ agonist, rosiglitazone (RGZ), blocks the molecular and functional effects of perinatal nicotine exposure on offspring lung. Pregnant Sprague-Dawley rat dams received placebo, nicotine, or nicotine + RGZ daily from embryonic day 6 until postnatal day 21, when respiratory system resistance, compliance, tracheal contractility, and the expression of markers of pulmonary contractility were determined. A significant increase in resistance and a decrease in compliance under basal conditions, with more pronounced changes following methacholine challenge, were observed with perinatal nicotine exposure compared with control. Tracheal constriction response and expression of mesenchymal markers of airway contractility were also significantly increased following perinatal nicotine exposure. Concomitant treatment with RGZ completely blocked the nicotine-induced alterations in pulmonary function, as well as the markers of airway contractility, at proximal and distal airway levels. These data suggest that perinatal smoke exposure-induced asthma can be effectively blocked by PPARγ agonists." @default.
• W2104427304 created "2016-06-24" @default.
• W2104427304 creator A5007798397 @default.
• W2104427304 creator A5016555349 @default.
• W2104427304 creator A5023940167 @default.
• W2104427304 creator A5056130715 @default.
• W2104427304 creator A5081473027 @default.
• W2104427304 creator A5090398853 @default.
• W2104427304 date "2011-05-01" @default.
• W2104427304 modified "2023-09-26" @default.
• W2104427304 title "PPARγ agonist rosiglitazone prevents perinatal nicotine exposure-induced asthma in rat offspring" @default.
• W2104427304 cites W123264792 @default.
• W2104427304 cites W1833176788 @default.
• W2104427304 cites W1914845986 @default.
• W2104427304 cites W1966493836 @default.
• W2104427304 cites W1975419457 @default.
• W2104427304 cites W1976079717 @default.
• W2104427304 cites W1978392269 @default.
• W2104427304 cites W1982977391 @default.
• W2104427304 cites W1989023854 @default.
• W2104427304 cites W1989343391 @default.
• W2104427304 cites W1993489169 @default.
• W2104427304 cites W1993523724 @default.
• W2104427304 cites W1997107477 @default.
• W2104427304 cites W1999991326 @default.
• W2104427304 cites W2000822621 @default.
• W2104427304 cites W2009306234 @default.
• W2104427304 cites W2020085025 @default.
• W2104427304 cites W2023178118 @default.
• W2104427304 cites W2029044788 @default.
• W2104427304 cites W2038379636 @default.
• W2104427304 cites W2053834750 @default.
• W2104427304 cites W2054276833 @default.
• W2104427304 cites W2055950330 @default.
• W2104427304 cites W2056303724 @default.
• W2104427304 cites W2056737153 @default.
• W2104427304 cites W2058068677 @default.
• W2104427304 cites W2060425781 @default.
• W2104427304 cites W2063830163 @default.
• W2104427304 cites W2072872532 @default.
• W2104427304 cites W2077180370 @default.
• W2104427304 cites W2082438428 @default.
• W2104427304 cites W2089564589 @default.
• W2104427304 cites W2093389636 @default.
• W2104427304 cites W2096234961 @default.
• W2104427304 cites W2104659264 @default.
• W2104427304 cites W2119675051 @default.
• W2104427304 cites W2120006832 @default.
• W2104427304 cites W2122212067 @default.
• W2104427304 cites W2124324711 @default.
• W2104427304 cites W2126043454 @default.
• W2104427304 cites W2127659986 @default.
• W2104427304 cites W2135171274 @default.
• W2104427304 cites W2137787283 @default.
• W2104427304 cites W2137923057 @default.
• W2104427304 cites W2151079096 @default.
• W2104427304 cites W2153779538 @default.
• W2104427304 cites W2160923426 @default.
• W2104427304 cites W2163574165 @default.
• W2104427304 cites W2164578308 @default.
• W2104427304 cites W2168788155 @default.
• W2104427304 cites W2198569282 @default.
• W2104427304 doi "https://doi.org/10.1152/ajplung.00337.2010" @default.
• W2104427304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4398871" @default.
• W2104427304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25659902" @default.
• W2104427304 hasPublicationYear "2011" @default.
• W2104427304 type Work @default.
• W2104427304 sameAs 2104427304 @default.
• W2104427304 citedByCount "46" @default.
• W2104427304 countsByYear W21044273042012 @default.
• W2104427304 countsByYear W21044273042013 @default.
• W2104427304 countsByYear W21044273042014 @default.
• W2104427304 countsByYear W21044273042015 @default.
• W2104427304 countsByYear W21044273042016 @default.
• W2104427304 countsByYear W21044273042017 @default.
• W2104427304 countsByYear W21044273042018 @default.
• W2104427304 countsByYear W21044273042019 @default.
• W2104427304 countsByYear W21044273042020 @default.
• W2104427304 countsByYear W21044273042021 @default.
• W2104427304 countsByYear W21044273042022 @default.
• W2104427304 crossrefType "journal-article" @default.
• W2104427304 hasAuthorship W2104427304A5007798397 @default.
• W2104427304 hasAuthorship W2104427304A5016555349 @default.
• W2104427304 hasAuthorship W2104427304A5023940167 @default.
• W2104427304 hasAuthorship W2104427304A5056130715 @default.
• W2104427304 hasAuthorship W2104427304A5081473027 @default.
• W2104427304 hasAuthorship W2104427304A5090398853 @default.
• W2104427304 hasBestOaLocation W21044273042 @default.
• W2104427304 hasConcept C112672928 @default.
• W2104427304 hasConcept C126322002 @default.
• W2104427304 hasConcept C134018914 @default.
• W2104427304 hasConcept C2777714996 @default.
• W2104427304 hasConcept C2779234561 @default.
• W2104427304 hasConcept C2779547902 @default.
• W2104427304 hasConcept C33362165 @default.
• W2104427304 hasConcept C39133596 @default.
• W2104427304 hasConcept C54355233 @default.
• W2104427304 hasConcept C71924100 @default.

• next