FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104428207> ?p ?o ?g. }

• W2104428207 endingPage "127" @default.
• W2104428207 startingPage "113" @default.
• W2104428207 abstract "We review here our attempts to achieve a better understanding of the structure—function relationship of antibody combining sites, and to gain insights into the engineering of antibodies with desired specificity and affinity. We have focused on a model system—antibodies to the hapten p-azophenylarsonate (Ars) derived from A/J mice. Oligonucleotide-directed mutagenesis was used to alter the sequence of the variable region genes of such anti-Ars antibodies. Mutant antibodies were generated in hybridoma cells following transfection of the altered genes, and the effects of the primary structure changes on antibody specificity, affinity, and idiotypic expression were assessed. These studies suggest that an antibody combining site with basic specificity for an antigen could be created by introducing a set of a few amino acid residues in the complementarity determining regions, and that the affinity of such a site could be improved one substitution at a time in a sequential manner." @default.
• W2104428207 created "2016-06-24" @default.
• W2104428207 creator A5003615763 @default.
• W2104428207 creator A5027337101 @default.
• W2104428207 creator A5049585135 @default.
• W2104428207 date "1993-01-01" @default.
• W2104428207 modified "2023-09-27" @default.
• W2104428207 title "Oligonucleotide-Directed Mutagenesis of Antibody Combining Sites" @default.
• W2104428207 cites W1965372574 @default.
• W2104428207 cites W1967507598 @default.
• W2104428207 cites W1971142781 @default.
• W2104428207 cites W1971427460 @default.
• W2104428207 cites W1973839401 @default.
• W2104428207 cites W1974869964 @default.
• W2104428207 cites W1980651107 @default.
• W2104428207 cites W1981197474 @default.
• W2104428207 cites W1988512414 @default.
• W2104428207 cites W1988903541 @default.
• W2104428207 cites W1989053318 @default.
• W2104428207 cites W1990646462 @default.
• W2104428207 cites W1993887766 @default.
• W2104428207 cites W1999100206 @default.
• W2104428207 cites W2000107365 @default.
• W2104428207 cites W2004303268 @default.
• W2104428207 cites W2008416020 @default.
• W2104428207 cites W2016067933 @default.
• W2104428207 cites W2017399810 @default.
• W2104428207 cites W2021153432 @default.
• W2104428207 cites W2023139689 @default.
• W2104428207 cites W2050188367 @default.
• W2104428207 cites W2054892173 @default.
• W2104428207 cites W2057294092 @default.
• W2104428207 cites W2063311322 @default.
• W2104428207 cites W2063618084 @default.
• W2104428207 cites W2068747743 @default.
• W2104428207 cites W2070266835 @default.
• W2104428207 cites W2071883654 @default.
• W2104428207 cites W2075097399 @default.
• W2104428207 cites W2081824858 @default.
• W2104428207 cites W2087289657 @default.
• W2104428207 cites W2111400669 @default.
• W2104428207 cites W2116026146 @default.
• W2104428207 cites W2120755294 @default.
• W2104428207 cites W2127552260 @default.
• W2104428207 cites W2131839976 @default.
• W2104428207 cites W2136766474 @default.
• W2104428207 cites W2150028279 @default.
• W2104428207 cites W2160240795 @default.
• W2104428207 cites W2163224235 @default.
• W2104428207 cites W2165039032 @default.
• W2104428207 cites W2745627398 @default.
• W2104428207 doi "https://doi.org/10.3109/08830189309061689" @default.
• W2104428207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8360579" @default.
• W2104428207 hasPublicationYear "1993" @default.
• W2104428207 type Work @default.
• W2104428207 sameAs 2104428207 @default.
• W2104428207 citedByCount "7" @default.
• W2104428207 countsByYear W21044282072013 @default.
• W2104428207 crossrefType "journal-article" @default.
• W2104428207 hasAuthorship W2104428207A5003615763 @default.
• W2104428207 hasAuthorship W2104428207A5027337101 @default.
• W2104428207 hasAuthorship W2104428207A5049585135 @default.
• W2104428207 hasConcept C103408237 @default.
• W2104428207 hasConcept C104317684 @default.
• W2104428207 hasConcept C129312508 @default.
• W2104428207 hasConcept C143065580 @default.
• W2104428207 hasConcept C147816474 @default.
• W2104428207 hasConcept C153911025 @default.
• W2104428207 hasConcept C159654299 @default.
• W2104428207 hasConcept C16318435 @default.
• W2104428207 hasConcept C181199279 @default.
• W2104428207 hasConcept C2781377902 @default.
• W2104428207 hasConcept C29144244 @default.
• W2104428207 hasConcept C54009773 @default.
• W2104428207 hasConcept C542903549 @default.
• W2104428207 hasConcept C54355233 @default.
• W2104428207 hasConcept C55493867 @default.
• W2104428207 hasConcept C70721500 @default.
• W2104428207 hasConcept C85630698 @default.
• W2104428207 hasConcept C86803240 @default.
• W2104428207 hasConcept C9418097 @default.
• W2104428207 hasConceptScore W2104428207C103408237 @default.
• W2104428207 hasConceptScore W2104428207C104317684 @default.
• W2104428207 hasConceptScore W2104428207C129312508 @default.
• W2104428207 hasConceptScore W2104428207C143065580 @default.
• W2104428207 hasConceptScore W2104428207C147816474 @default.
• W2104428207 hasConceptScore W2104428207C153911025 @default.
• W2104428207 hasConceptScore W2104428207C159654299 @default.
• W2104428207 hasConceptScore W2104428207C16318435 @default.
• W2104428207 hasConceptScore W2104428207C181199279 @default.
• W2104428207 hasConceptScore W2104428207C2781377902 @default.
• W2104428207 hasConceptScore W2104428207C29144244 @default.
• W2104428207 hasConceptScore W2104428207C54009773 @default.
• W2104428207 hasConceptScore W2104428207C542903549 @default.
• W2104428207 hasConceptScore W2104428207C54355233 @default.
• W2104428207 hasConceptScore W2104428207C55493867 @default.
• W2104428207 hasConceptScore W2104428207C70721500 @default.
• W2104428207 hasConceptScore W2104428207C85630698 @default.

• next