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• W2104433712 abstract "Membrane homeostasis is maintained by exocytosis and endocytosis. The molecular mechanisms regulating the interplay between these two processes are not clear. Inositol hexakisphosphate (InsP(6)) is under metabolic control and serves as a signal in the pancreatic beta cell stimulus-secretion coupling by increasing Ca(2+)-channel activity and insulin exocytosis. We now show that InsP(6) also promotes dynamin I-mediated endocytosis in the pancreatic beta cell. This effect of InsP(6) depends on calcineurin-induced dephosphorylation and is accounted for by both activation of protein kinase C and inhibition of the phosphoinositide phosphatase synaptojanin and thereby formation of phosphatidylinositol 4,5-bisphosphate. In regulating both exocytosis and endocytosis, InsP(6) thus may have an essential integral role in membrane trafficking." @default.
• W2104433712 created "2016-06-24" @default.
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• W2104433712 date "2002-05-14" @default.
• W2104433712 modified "2023-10-18" @default.
• W2104433712 title "Inositol hexakisphosphate promotes dynamin I- mediated endocytosis" @default.
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• W2104433712 doi "https://doi.org/10.1073/pnas.102157499" @default.
• W2104433712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/124478" @default.
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