FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104435845> ?p ?o ?g. }

• W2104435845 endingPage "328" @default.
• W2104435845 startingPage "318" @default.
• W2104435845 abstract "Ursodeoxycholic acid has been widely used as a therapeutic agent in cholesterol gallstones and liver disease patients, but its mechanism of action is still under investigation.The protective effect of ursodeoxycholic acid, both free, taurine and glycine conjugated, against hepatotoxic bile acids such as chenodeoxycholic acid and its taurine amidate was studied in bile fistula rats and compared with the cholic and taurocholic acid effect.Tauroursodeoxycholic acid, glycine ursodeoxycholic acid, ursodeoxycholic acid, taurocholic acid and cholic acid were infused iv over 1 hour (8 micromol/min/kg) together with an equimolar dose of either taurochenodeoxycholic acid or chenodeoxycholc acid. Bile flow, total and individual bile acid and biliary lactate dehydrogenase and alkaline phosphatase enzymes were measured.Taurochenodeoxycholic acid and chenodeoxycholc acid caused cholestasis and liver damage associated with a decreased bile flow, total and individual bile acids secretion accompanied by a biliary leakage of lactate dehydrogenase and alkaline phosphatase enzymes. Tauroursodeoxycholic acid, glycine ursodeoxycholic acid, ursodeoxycholic acid and taurocholic acid, on the contrary, were choleretic, inducing an opposite effect on biliary parameters. Simultaneous infusion of taurochenodeoxycholic acid and the protective bile acid resulted in a functional and morphological improvement of the above parameters in the following order: glycine ursodeoxycholic acid > tauroursodeoxycholic acid > ursodeoxycholic acid followed by taurocholic acid; cholic acid was ineffective.The results show the protective effect of glycine ursodeoxycholic acid, ursodeoxycholic acid and tauroursodeoxycholic acid. This may be due to a facilitated transport of the toxic bile acid into bile; conjugation with taurine is less effective than glycine. Finally, the better protective effect of ursodeoxycholic acid and its amidates with respect to cholic acid and its taurine conjugated form seems to be related to their different lipophilicity and micellar forming capacity." @default.
• W2104435845 created "2016-06-24" @default.
• W2104435845 creator A5003444448 @default.
• W2104435845 creator A5013734371 @default.
• W2104435845 creator A5017477927 @default.
• W2104435845 creator A5030701699 @default.
• W2104435845 creator A5033420164 @default.
• W2104435845 creator A5058373325 @default.
• W2104435845 creator A5066270284 @default.
• W2104435845 date "2000-05-01" @default.
• W2104435845 modified "2023-10-06" @default.
• W2104435845 title "Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid" @default.
• W2104435845 cites W1564906832 @default.
• W2104435845 cites W167020474 @default.
• W2104435845 cites W1744924361 @default.
• W2104435845 cites W1752796088 @default.
• W2104435845 cites W1858519155 @default.
• W2104435845 cites W1862996613 @default.
• W2104435845 cites W1875161787 @default.
• W2104435845 cites W1965984516 @default.
• W2104435845 cites W1968493998 @default.
• W2104435845 cites W1970664739 @default.
• W2104435845 cites W1977449623 @default.
• W2104435845 cites W1979948452 @default.
• W2104435845 cites W1980228181 @default.
• W2104435845 cites W1987227282 @default.
• W2104435845 cites W1995657138 @default.
• W2104435845 cites W200919880 @default.
• W2104435845 cites W2013220565 @default.
• W2104435845 cites W2013803788 @default.
• W2104435845 cites W2024413509 @default.
• W2104435845 cites W2027546299 @default.
• W2104435845 cites W2036433609 @default.
• W2104435845 cites W2037692808 @default.
• W2104435845 cites W2040962527 @default.
• W2104435845 cites W2042761114 @default.
• W2104435845 cites W2060388420 @default.
• W2104435845 cites W2061569374 @default.
• W2104435845 cites W2075432722 @default.
• W2104435845 cites W2084056438 @default.
• W2104435845 cites W2088136334 @default.
• W2104435845 cites W2100345391 @default.
• W2104435845 cites W2121848003 @default.
• W2104435845 cites W2166665362 @default.
• W2104435845 cites W2176624819 @default.
• W2104435845 cites W2316970164 @default.
• W2104435845 cites W2406980072 @default.
• W2104435845 cites W2411222208 @default.
• W2104435845 cites W2412385315 @default.
• W2104435845 cites W2412606231 @default.
• W2104435845 cites W2413763447 @default.
• W2104435845 cites W2415824838 @default.
• W2104435845 cites W2416944829 @default.
• W2104435845 cites W2418685580 @default.
• W2104435845 cites W2424559270 @default.
• W2104435845 cites W65249248 @default.
• W2104435845 cites W1502423391 @default.
• W2104435845 doi "https://doi.org/10.1016/s1590-8658(00)80025-0" @default.
• W2104435845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11515630" @default.
• W2104435845 hasPublicationYear "2000" @default.
• W2104435845 type Work @default.
• W2104435845 sameAs 2104435845 @default.
• W2104435845 citedByCount "7" @default.
• W2104435845 crossrefType "journal-article" @default.
• W2104435845 hasAuthorship W2104435845A5003444448 @default.
• W2104435845 hasAuthorship W2104435845A5013734371 @default.
• W2104435845 hasAuthorship W2104435845A5017477927 @default.
• W2104435845 hasAuthorship W2104435845A5030701699 @default.
• W2104435845 hasAuthorship W2104435845A5033420164 @default.
• W2104435845 hasAuthorship W2104435845A5058373325 @default.
• W2104435845 hasAuthorship W2104435845A5066270284 @default.
• W2104435845 hasConcept C126322002 @default.
• W2104435845 hasConcept C139447449 @default.
• W2104435845 hasConcept C158617107 @default.
• W2104435845 hasConcept C185592680 @default.
• W2104435845 hasConcept C2775900799 @default.
• W2104435845 hasConcept C2777422422 @default.
• W2104435845 hasConcept C2778593092 @default.
• W2104435845 hasConcept C2779399885 @default.
• W2104435845 hasConcept C2779701627 @default.
• W2104435845 hasConcept C2780420665 @default.
• W2104435845 hasConcept C2780480987 @default.
• W2104435845 hasConcept C2780749602 @default.
• W2104435845 hasConcept C2780965833 @default.
• W2104435845 hasConcept C2781089062 @default.
• W2104435845 hasConcept C515207424 @default.
• W2104435845 hasConcept C55493867 @default.
• W2104435845 hasConcept C71924100 @default.
• W2104435845 hasConceptScore W2104435845C126322002 @default.
• W2104435845 hasConceptScore W2104435845C139447449 @default.
• W2104435845 hasConceptScore W2104435845C158617107 @default.
• W2104435845 hasConceptScore W2104435845C185592680 @default.
• W2104435845 hasConceptScore W2104435845C2775900799 @default.
• W2104435845 hasConceptScore W2104435845C2777422422 @default.
• W2104435845 hasConceptScore W2104435845C2778593092 @default.
• W2104435845 hasConceptScore W2104435845C2779399885 @default.
• W2104435845 hasConceptScore W2104435845C2779701627 @default.
• W2104435845 hasConceptScore W2104435845C2780420665 @default.

• next