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- W2104436796 abstract "Although the safety of liver surgery has improved enormously, hepatic surgery continues to face challenging complications. Therefore, improvements supported by evidence-based guidelines are still required. The conduct of randomized controlled trials in liver surgery using dichotomous outcomes requires a large sample size. The use of surrogate endpoints (SEPs) reduces sample size but SEPs should be validated before use.The aim of this review was to summarize the SEPs used in hepatic surgery related trials, their definitions and recapitulating the evidence validating their use.A systematic computerized literature search in the biomedical database PubMed using the MeSH terms 'hepatectomy' or 'liver resection' or 'liver transection' was conducted. Search was limited to papers written in the English language and published between 1 January 2000 and 1 January 2010.A total of 593 articles met the search terms and 49 articles were included in the final selection. Standard biochemical liver functions tests were the most frequently used SEP (32 of 49 the studies). The used definitions of SEPs varied greatly among the studies. Most studies referred to earlier published material to justify their choice of SEP. However, no validating studies were found.Many SEPs are used in liver surgery trials however there is little evidence validating them." @default.
- W2104436796 created "2016-06-24" @default.
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- W2104436796 date "2013-05-01" @default.
- W2104436796 modified "2023-10-17" @default.
- W2104436796 title "Surrogate endpoints in liver surgery related trials: a systematic review of the literature" @default.
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- W2104436796 doi "https://doi.org/10.1111/j.1477-2574.2012.00590.x" @default.
- W2104436796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3633033" @default.
- W2104436796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23323939" @default.
- W2104436796 hasPublicationYear "2013" @default.
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