FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104437462> ?p ?o ?g. }

• W2104437462 endingPage "2270" @default.
• W2104437462 startingPage "2261" @default.
• W2104437462 abstract "We have investigated the expression and localization of fibronectin, laminin, and their receptors, and we used an in vitro chick chondrocyte differentiation model to define a time hierarchy for their appearance in early chondro-genesis and to determine their role in the cell condensation process. By serum fibronectin depletion/reconstitution, or GRGDSP peptide competition experiments, we show that fibronectin contributes to the initial cell-cell interactions that occur during condensation. In later stages, a down-regulation of both fibronectin and of its alpha5beta1 integrin receptor occur, as demonstrated by mRNA and protein kinetics. Immunolocalisation studies suggest that the reduction of fibronectin in discrete areas is involved in local activation of the cell differentiation program. Furthermore, we show that laminin is expressed during the in vitro cell condensation process in areas that are negative for fibronectin staining. The types of laminin as well as the timing of expression have been determined by northern blot and RT-PCR analyses. The highest levels of expression are coincident with maximal cell aggregation. The alpha3beta1 laminin receptor, highly expressed in dedifferentiated cells, follows later on the ligand trend. During in vitro chondrogenesis, a down-regulation in the B isoform, and an up-regulation of the A isoform, of the alpha subunit of the alpha6beta1 laminin receptor occurs. Immunolocalisation studies suggest that laminin is involved in the definition of differentiating areas as opposed to non differentiating areas of the condensed region, i.e. the periphery, which eventually gives rise to the perichondrium." @default.
• W2104437462 created "2016-06-24" @default.
• W2104437462 creator A5002060153 @default.
• W2104437462 creator A5008340388 @default.
• W2104437462 creator A5009248957 @default.
• W2104437462 creator A5027971423 @default.
• W2104437462 creator A5041339142 @default.
• W2104437462 creator A5056634710 @default.
• W2104437462 creator A5064960380 @default.
• W2104437462 creator A5081172698 @default.
• W2104437462 creator A5086678415 @default.
• W2104437462 date "1997-09-15" @default.
• W2104437462 modified "2023-10-09" @default.
• W2104437462 title "Regulated expression of fibronectin, laminin and related integrin receptors during the early chondrocyte differentiation" @default.
• W2104437462 cites W1501414848 @default.
• W2104437462 cites W1512678034 @default.
• W2104437462 cites W1578285665 @default.
• W2104437462 cites W1593255198 @default.
• W2104437462 cites W1804065695 @default.
• W2104437462 cites W1963506793 @default.
• W2104437462 cites W1964257347 @default.
• W2104437462 cites W1969508095 @default.
• W2104437462 cites W1986176372 @default.
• W2104437462 cites W1989582506 @default.
• W2104437462 cites W1989777218 @default.
• W2104437462 cites W1991074887 @default.
• W2104437462 cites W2002143767 @default.
• W2104437462 cites W2006425726 @default.
• W2104437462 cites W2009598071 @default.
• W2104437462 cites W2011497948 @default.
• W2104437462 cites W2024144069 @default.
• W2104437462 cites W2029231027 @default.
• W2104437462 cites W2031170198 @default.
• W2104437462 cites W2031304372 @default.
• W2104437462 cites W2032380793 @default.
• W2104437462 cites W2056031607 @default.
• W2104437462 cites W2059080130 @default.
• W2104437462 cites W2062557303 @default.
• W2104437462 cites W2065933206 @default.
• W2104437462 cites W2068249430 @default.
• W2104437462 cites W2085462195 @default.
• W2104437462 cites W2087178104 @default.
• W2104437462 cites W2090892805 @default.
• W2104437462 cites W2093514870 @default.
• W2104437462 cites W2099292585 @default.
• W2104437462 cites W2100837269 @default.
• W2104437462 cites W2101108802 @default.
• W2104437462 cites W2104102239 @default.
• W2104437462 cites W2106232134 @default.
• W2104437462 cites W2110909340 @default.
• W2104437462 cites W2116596989 @default.
• W2104437462 cites W2122608596 @default.
• W2104437462 cites W2133526415 @default.
• W2104437462 cites W2135121318 @default.
• W2104437462 cites W2140034535 @default.
• W2104437462 cites W2149049171 @default.
• W2104437462 cites W2167639459 @default.
• W2104437462 cites W4211112402 @default.
• W2104437462 cites W4294216491 @default.
• W2104437462 doi "https://doi.org/10.1242/jcs.110.18.2261" @default.
• W2104437462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9378775" @default.
• W2104437462 hasPublicationYear "1997" @default.
• W2104437462 type Work @default.
• W2104437462 sameAs 2104437462 @default.
• W2104437462 citedByCount "89" @default.
• W2104437462 countsByYear W21044374622012 @default.
• W2104437462 countsByYear W21044374622013 @default.
• W2104437462 countsByYear W21044374622014 @default.
• W2104437462 countsByYear W21044374622015 @default.
• W2104437462 countsByYear W21044374622016 @default.
• W2104437462 countsByYear W21044374622017 @default.
• W2104437462 countsByYear W21044374622018 @default.
• W2104437462 countsByYear W21044374622019 @default.
• W2104437462 countsByYear W21044374622020 @default.
• W2104437462 crossrefType "journal-article" @default.
• W2104437462 hasAuthorship W2104437462A5002060153 @default.
• W2104437462 hasAuthorship W2104437462A5008340388 @default.
• W2104437462 hasAuthorship W2104437462A5009248957 @default.
• W2104437462 hasAuthorship W2104437462A5027971423 @default.
• W2104437462 hasAuthorship W2104437462A5041339142 @default.
• W2104437462 hasAuthorship W2104437462A5056634710 @default.
• W2104437462 hasAuthorship W2104437462A5064960380 @default.
• W2104437462 hasAuthorship W2104437462A5081172698 @default.
• W2104437462 hasAuthorship W2104437462A5086678415 @default.
• W2104437462 hasConcept C153911025 @default.
• W2104437462 hasConcept C170493617 @default.
• W2104437462 hasConcept C189165786 @default.
• W2104437462 hasConcept C195687474 @default.
• W2104437462 hasConcept C202751555 @default.
• W2104437462 hasConcept C2779814568 @default.
• W2104437462 hasConcept C2781403057 @default.
• W2104437462 hasConcept C55493867 @default.
• W2104437462 hasConcept C86492073 @default.
• W2104437462 hasConcept C86803240 @default.
• W2104437462 hasConcept C95444343 @default.
• W2104437462 hasConceptScore W2104437462C153911025 @default.
• W2104437462 hasConceptScore W2104437462C170493617 @default.
• W2104437462 hasConceptScore W2104437462C189165786 @default.

• next