FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104450255> ?p ?o ?g. }

• W2104450255 endingPage "G643" @default.
• W2104450255 startingPage "G634" @default.
• W2104450255 abstract "In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes. In the liver, melatonin suppresses oxidative damage and ameliorates fibrosis. No information exists regarding the role of melatonin in the regulation of biliary hyperplasia. We evaluated the mechanisms of action by which melatonin regulates the growth of cholangiocytes. In normal and BDL rats, we determined the hepatic distribution of MT1, MT2, and the clock genes, CLOCK, BMAL1, CRY1, and PER1. Normal and BDL (immediately after BDL) rats were treated in vivo with melatonin before evaluating 1) serum levels of melatonin, bilirubin, and transaminases; 2) intrahepatic bile duct mass (IBDM) in liver sections; and 3) the expression of MT1 and MT2, clock genes, and PKA phosphorylation. In vitro, large cholangiocytes were stimulated with melatonin in the absence/presence of luzindole (MT1/MT2 antagonist) and 4-phenyl-2-propionamidotetralin (MT2 antagonist) before evaluating cell proliferation, cAMP levels, and PKA phosphorylation. Cholangiocytes express MT1 and MT2, CLOCK, BMAL1, CRY1, and PER1 that were all upregulated following BDL. Administration of melatonin to BDL rats decreased IBDM, serum bilirubin and transaminases levels, the expression of all clock genes, cAMP levels, and PKA phosphorylation in cholangiocytes. In vitro, melatonin decreased the proliferation, cAMP levels, and PKA phosphorylation, decreases that were blocked by luzindole. Melatonin may be important in the management of biliary hyperplasia in human cholangiopathies." @default.
• W2104450255 created "2016-06-24" @default.
• W2104450255 creator A5008932925 @default.
• W2104450255 creator A5016070188 @default.
• W2104450255 creator A5027095830 @default.
• W2104450255 creator A5029205234 @default.
• W2104450255 creator A5030400303 @default.
• W2104450255 creator A5045220703 @default.
• W2104450255 creator A5046002870 @default.
• W2104450255 creator A5047599959 @default.
• W2104450255 creator A5056263186 @default.
• W2104450255 creator A5057239346 @default.
• W2104450255 creator A5059963876 @default.
• W2104450255 creator A5066151943 @default.
• W2104450255 creator A5077994068 @default.
• W2104450255 creator A5081350888 @default.
• W2104450255 creator A5082941920 @default.
• W2104450255 creator A5091026103 @default.
• W2104450255 date "2011-10-01" @default.
• W2104450255 modified "2023-09-26" @default.
• W2104450255 title "Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors" @default.
• W2104450255 cites W105688798 @default.
• W2104450255 cites W1571291597 @default.
• W2104450255 cites W1677076286 @default.
• W2104450255 cites W1752945314 @default.
• W2104450255 cites W1801815609 @default.
• W2104450255 cites W1844272684 @default.
• W2104450255 cites W1861134585 @default.
• W2104450255 cites W1895162240 @default.
• W2104450255 cites W1896617039 @default.
• W2104450255 cites W1906327591 @default.
• W2104450255 cites W1908700199 @default.
• W2104450255 cites W1964716875 @default.
• W2104450255 cites W1966292953 @default.
• W2104450255 cites W1971013426 @default.
• W2104450255 cites W1973171621 @default.
• W2104450255 cites W1975624789 @default.
• W2104450255 cites W1981351345 @default.
• W2104450255 cites W1982708256 @default.
• W2104450255 cites W1993432842 @default.
• W2104450255 cites W1997179110 @default.
• W2104450255 cites W1999169336 @default.
• W2104450255 cites W2005792434 @default.
• W2104450255 cites W2006861225 @default.
• W2104450255 cites W2010038812 @default.
• W2104450255 cites W2013244539 @default.
• W2104450255 cites W2020244868 @default.
• W2104450255 cites W2028532862 @default.
• W2104450255 cites W2030295815 @default.
• W2104450255 cites W2030768113 @default.
• W2104450255 cites W2032801951 @default.
• W2104450255 cites W2033135582 @default.
• W2104450255 cites W2038341639 @default.
• W2104450255 cites W2039425156 @default.
• W2104450255 cites W2047587215 @default.
• W2104450255 cites W2055296962 @default.
• W2104450255 cites W2064216898 @default.
• W2104450255 cites W2065493935 @default.
• W2104450255 cites W2067289072 @default.
• W2104450255 cites W2067594167 @default.
• W2104450255 cites W2071469400 @default.
• W2104450255 cites W2072891772 @default.
• W2104450255 cites W2075256377 @default.
• W2104450255 cites W2077038726 @default.
• W2104450255 cites W2083510568 @default.
• W2104450255 cites W2084074983 @default.
• W2104450255 cites W2084321542 @default.
• W2104450255 cites W2086147744 @default.
• W2104450255 cites W2091385411 @default.
• W2104450255 cites W2121897465 @default.
• W2104450255 cites W2124288445 @default.
• W2104450255 cites W2131239750 @default.
• W2104450255 cites W2136350449 @default.
• W2104450255 cites W2138270252 @default.
• W2104450255 cites W2143609597 @default.
• W2104450255 cites W2144302408 @default.
• W2104450255 cites W2151429947 @default.
• W2104450255 cites W2153549414 @default.
• W2104450255 cites W2166743029 @default.
• W2104450255 cites W2172898047 @default.
• W2104450255 cites W2243572961 @default.
• W2104450255 cites W2284306206 @default.
• W2104450255 cites W2323516874 @default.
• W2104450255 doi "https://doi.org/10.1152/ajpgi.00206.2011" @default.
• W2104450255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3191552" @default.
• W2104450255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21757639" @default.
• W2104450255 hasPublicationYear "2011" @default.
• W2104450255 type Work @default.
• W2104450255 sameAs 2104450255 @default.
• W2104450255 citedByCount "51" @default.
• W2104450255 countsByYear W21044502552012 @default.
• W2104450255 countsByYear W21044502552013 @default.
• W2104450255 countsByYear W21044502552014 @default.
• W2104450255 countsByYear W21044502552015 @default.
• W2104450255 countsByYear W21044502552016 @default.
• W2104450255 countsByYear W21044502552017 @default.
• W2104450255 countsByYear W21044502552018 @default.
• W2104450255 countsByYear W21044502552019 @default.

• next