Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104460069> ?p ?o ?g. }
- W2104460069 endingPage "1043" @default.
- W2104460069 startingPage "1043" @default.
- W2104460069 abstract "Several lines of emerging evidence suggest that dysfunction of gamma-aminobutyric acid (GABA) systems is associated with major depression. However, investigation of this hypothesis is limited by difficulty obtaining noninvasive in vivo measures of brain GABA levels. In this study we used in vivo proton magnetic resonance spectroscopy to investigate the hypothesis that abnormalities in the GABA neurotransmitter system are associated with the neurobiologic processes of depression.The GABA levels were measured in the occipital cortex of medication-free depressed patients meeting DSM-IV criteria (n = 14) and healthy control subjects with no history of mental illness (n = 18) using a localized difference editing proton magnetic resonance spectroscopy protocol. An analysis of covariance was employed to examine the effects of depression, sex, and age.The depressed patients demonstrated a highly significant (52%) reduction in occipital cortex GABA levels compared with the group of healthy subjects. While there were significant age and sex effects, there was no interaction of diagnosis with either age or sex.This study provides the first evidence of abnormally low cortical GABA concentrations in the brains of depressed patients." @default.
- W2104460069 created "2016-06-24" @default.
- W2104460069 creator A5012699156 @default.
- W2104460069 creator A5018643148 @default.
- W2104460069 creator A5037185919 @default.
- W2104460069 creator A5046602530 @default.
- W2104460069 creator A5057146350 @default.
- W2104460069 creator A5065391092 @default.
- W2104460069 creator A5071039477 @default.
- W2104460069 creator A5085513534 @default.
- W2104460069 creator A5090099139 @default.
- W2104460069 date "1999-11-01" @default.
- W2104460069 modified "2023-10-17" @default.
- W2104460069 title "Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy" @default.
- W2104460069 cites W165280916 @default.
- W2104460069 cites W1964201164 @default.
- W2104460069 cites W1989256798 @default.
- W2104460069 cites W1989422254 @default.
- W2104460069 cites W1994961220 @default.
- W2104460069 cites W1996597325 @default.
- W2104460069 cites W1999439609 @default.
- W2104460069 cites W2000313416 @default.
- W2104460069 cites W2002383337 @default.
- W2104460069 cites W2005564534 @default.
- W2104460069 cites W2008578135 @default.
- W2104460069 cites W2017067141 @default.
- W2104460069 cites W2024435902 @default.
- W2104460069 cites W2029624481 @default.
- W2104460069 cites W2034359651 @default.
- W2104460069 cites W2035775064 @default.
- W2104460069 cites W2041069409 @default.
- W2104460069 cites W2044452957 @default.
- W2104460069 cites W2058278817 @default.
- W2104460069 cites W2063079339 @default.
- W2104460069 cites W2068857906 @default.
- W2104460069 cites W2069405063 @default.
- W2104460069 cites W2080932501 @default.
- W2104460069 cites W2083651237 @default.
- W2104460069 cites W2117231835 @default.
- W2104460069 cites W2143438415 @default.
- W2104460069 cites W2153816902 @default.
- W2104460069 cites W2158388157 @default.
- W2104460069 cites W2159061031 @default.
- W2104460069 cites W2337622937 @default.
- W2104460069 cites W2409763168 @default.
- W2104460069 cites W2415540009 @default.
- W2104460069 cites W2417059513 @default.
- W2104460069 cites W2430803623 @default.
- W2104460069 cites W2465922693 @default.
- W2104460069 cites W2735928575 @default.
- W2104460069 doi "https://doi.org/10.1001/archpsyc.56.11.1043" @default.
- W2104460069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10565505" @default.
- W2104460069 hasPublicationYear "1999" @default.
- W2104460069 type Work @default.
- W2104460069 sameAs 2104460069 @default.
- W2104460069 citedByCount "574" @default.
- W2104460069 countsByYear W21044600692012 @default.
- W2104460069 countsByYear W21044600692013 @default.
- W2104460069 countsByYear W21044600692014 @default.
- W2104460069 countsByYear W21044600692015 @default.
- W2104460069 countsByYear W21044600692016 @default.
- W2104460069 countsByYear W21044600692017 @default.
- W2104460069 countsByYear W21044600692018 @default.
- W2104460069 countsByYear W21044600692019 @default.
- W2104460069 countsByYear W21044600692020 @default.
- W2104460069 countsByYear W21044600692021 @default.
- W2104460069 countsByYear W21044600692022 @default.
- W2104460069 countsByYear W21044600692023 @default.
- W2104460069 crossrefType "journal-article" @default.
- W2104460069 hasAuthorship W2104460069A5012699156 @default.
- W2104460069 hasAuthorship W2104460069A5018643148 @default.
- W2104460069 hasAuthorship W2104460069A5037185919 @default.
- W2104460069 hasAuthorship W2104460069A5046602530 @default.
- W2104460069 hasAuthorship W2104460069A5057146350 @default.
- W2104460069 hasAuthorship W2104460069A5065391092 @default.
- W2104460069 hasAuthorship W2104460069A5071039477 @default.
- W2104460069 hasAuthorship W2104460069A5085513534 @default.
- W2104460069 hasAuthorship W2104460069A5090099139 @default.
- W2104460069 hasConcept C118552586 @default.
- W2104460069 hasConcept C121332964 @default.
- W2104460069 hasConcept C126322002 @default.
- W2104460069 hasConcept C139719470 @default.
- W2104460069 hasConcept C150903083 @default.
- W2104460069 hasConcept C15744967 @default.
- W2104460069 hasConcept C162324750 @default.
- W2104460069 hasConcept C169760540 @default.
- W2104460069 hasConcept C169900460 @default.
- W2104460069 hasConcept C170493617 @default.
- W2104460069 hasConcept C207001950 @default.
- W2104460069 hasConcept C2776219046 @default.
- W2104460069 hasConcept C2776867660 @default.
- W2104460069 hasConcept C2777348757 @default.
- W2104460069 hasConcept C2777477808 @default.
- W2104460069 hasConcept C2777771985 @default.
- W2104460069 hasConcept C2780051608 @default.
- W2104460069 hasConcept C2988005100 @default.
- W2104460069 hasConcept C46141821 @default.
- W2104460069 hasConcept C529278444 @default.