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- W2104461741 endingPage "1068" @default.
- W2104461741 startingPage "1052" @default.
- W2104461741 abstract "The giant protein titin forms a unique filament network in cardiomyocytes, which engages in both mechanical and signaling functions of the heart. TTN , which encodes titin, is also a major human disease gene. In this review, we cover the roles of cardiac titin in normal and failing hearts, with a special emphasis on the contribution of titin to diastolic stiffness. We provide an update on disease-associated titin mutations in cardiac and skeletal muscles and summarize what is known about the impact of protein–protein interactions on titin properties and functions. We discuss the importance of titin-isoform shifts and titin phosphorylation, as well as titin modifications related to oxidative stress, in adjusting the diastolic stiffness of the healthy and the failing heart. Along the way we distinguish among titin alterations in systolic and in diastolic heart failure and ponder the evidence for titin stiffness as a potential target for pharmacological intervention in heart disease." @default.
- W2104461741 created "2016-06-24" @default.
- W2104461741 creator A5002233320 @default.
- W2104461741 creator A5068650860 @default.
- W2104461741 date "2014-03-14" @default.
- W2104461741 modified "2023-10-11" @default.
- W2104461741 title "Gigantic Business" @default.
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