FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104463631> ?p ?o ?g. }

• W2104463631 endingPage "2171" @default.
• W2104463631 startingPage "2167" @default.
• W2104463631 abstract "Alpha-hemolysin is an Escherichia coli exotoxin that enhances bacterial virulence, has profound effects on leukocytes in vitro, and induces the release of interleukin-1 (IL-1) but not tumor necrosis factor (TNF) from human monocytes in vitro. The purpose of this study was to examine alpha-hemolysin's influence on virulence and TNF and IL-1 production in vivo. Two genetically engineered, isogeneic strains of E. coli were used; one variant produces alpha-hemolysin, and the other does not. Male BALB/c mice were injected with either of the two variants and serum TNF and IL-1 were assayed. These results were compared with those obtained from the injection of either of two serotypes of lipopolysaccharide (LPS). The nonhemolytic E. coli strain produced no mortality and no significant elevation of serum TNF or IL-1 levels. In contrast, equal inocula of the hemolytic E. coli strain produced significant mortality and elevation of serum IL-1 levels. No significant elevation of TNF levels was detected in this group despite high-level mortality. A pattern of induction of mortality and elevation of serum IL-1 levels without elevation of serum TNF levels is distinct from the pattern typical of LPS. In these experiments, both serotypes of LPS caused elevations of TNF and IL-1 levels whether or not mortality was induced. Thus, alpha-hemolysin produces a cytokine response in vivo that is similar to that previously demonstrated in vitro by Bhakdi et al. (S. Bhakdi, M. Muhly, S. Korom, and G. Schmidt, J. Clin. Invest. 85:1746-1753, 1990) and appears to induce mortality independently of serum TNF." @default.
• W2104463631 created "2016-06-24" @default.
• W2104463631 creator A5022183693 @default.
• W2104463631 creator A5060547232 @default.
• W2104463631 creator A5078153822 @default.
• W2104463631 creator A5085685364 @default.
• W2104463631 creator A5088618193 @default.
• W2104463631 date "1996-06-01" @default.
• W2104463631 modified "2023-09-27" @default.
• W2104463631 title "In vivo cytokine response to Escherichia coli alpha-hemolysin determined with genetically engineered hemolytic and nonhemolytic E. coli variants" @default.
• W2104463631 cites W1870707005 @default.
• W2104463631 cites W1881871190 @default.
• W2104463631 cites W1901894556 @default.
• W2104463631 cites W1903870221 @default.
• W2104463631 cites W1904553924 @default.
• W2104463631 cites W1908815739 @default.
• W2104463631 cites W1918658321 @default.
• W2104463631 cites W1920049106 @default.
• W2104463631 cites W1923510456 @default.
• W2104463631 cites W1926535052 @default.
• W2104463631 cites W1929171476 @default.
• W2104463631 cites W1946310958 @default.
• W2104463631 cites W1967309573 @default.
• W2104463631 cites W2004283601 @default.
• W2104463631 cites W2018263315 @default.
• W2104463631 cites W2018931269 @default.
• W2104463631 cites W2030235062 @default.
• W2104463631 cites W2034048814 @default.
• W2104463631 cites W2036005165 @default.
• W2104463631 cites W2077486119 @default.
• W2104463631 cites W2087887478 @default.
• W2104463631 cites W2095078025 @default.
• W2104463631 cites W2107533276 @default.
• W2104463631 cites W2122339994 @default.
• W2104463631 cites W2124040440 @default.
• W2104463631 cites W2125851614 @default.
• W2104463631 cites W2133736504 @default.
• W2104463631 cites W2135048085 @default.
• W2104463631 cites W2147409348 @default.
• W2104463631 cites W2148551687 @default.
• W2104463631 cites W2148583189 @default.
• W2104463631 cites W2149349927 @default.
• W2104463631 cites W2157252109 @default.
• W2104463631 cites W2313260476 @default.
• W2104463631 cites W2335756740 @default.
• W2104463631 cites W4211088435 @default.
• W2104463631 doi "https://doi.org/10.1128/iai.64.6.2167-2171.1996" @default.
• W2104463631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/174051" @default.
• W2104463631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8675322" @default.
• W2104463631 hasPublicationYear "1996" @default.
• W2104463631 type Work @default.
• W2104463631 sameAs 2104463631 @default.
• W2104463631 citedByCount "24" @default.
• W2104463631 countsByYear W21044636312012 @default.
• W2104463631 countsByYear W21044636312013 @default.
• W2104463631 countsByYear W21044636312014 @default.
• W2104463631 countsByYear W21044636312019 @default.
• W2104463631 countsByYear W21044636312021 @default.
• W2104463631 countsByYear W21044636312022 @default.
• W2104463631 crossrefType "journal-article" @default.
• W2104463631 hasAuthorship W2104463631A5022183693 @default.
• W2104463631 hasAuthorship W2104463631A5060547232 @default.
• W2104463631 hasAuthorship W2104463631A5078153822 @default.
• W2104463631 hasAuthorship W2104463631A5085685364 @default.
• W2104463631 hasAuthorship W2104463631A5088618193 @default.
• W2104463631 hasBestOaLocation W21044636311 @default.
• W2104463631 hasConcept C104317684 @default.
• W2104463631 hasConcept C136139683 @default.
• W2104463631 hasConcept C150903083 @default.
• W2104463631 hasConcept C17991360 @default.
• W2104463631 hasConcept C202751555 @default.
• W2104463631 hasConcept C203014093 @default.
• W2104463631 hasConcept C207001950 @default.
• W2104463631 hasConcept C2777367657 @default.
• W2104463631 hasConcept C2778690821 @default.
• W2104463631 hasConcept C2778723905 @default.
• W2104463631 hasConcept C2778754761 @default.
• W2104463631 hasConcept C547475151 @default.
• W2104463631 hasConcept C55493867 @default.
• W2104463631 hasConcept C60987743 @default.
• W2104463631 hasConcept C86803240 @default.
• W2104463631 hasConcept C89423630 @default.
• W2104463631 hasConceptScore W2104463631C104317684 @default.
• W2104463631 hasConceptScore W2104463631C136139683 @default.
• W2104463631 hasConceptScore W2104463631C150903083 @default.
• W2104463631 hasConceptScore W2104463631C17991360 @default.
• W2104463631 hasConceptScore W2104463631C202751555 @default.
• W2104463631 hasConceptScore W2104463631C203014093 @default.
• W2104463631 hasConceptScore W2104463631C207001950 @default.
• W2104463631 hasConceptScore W2104463631C2777367657 @default.
• W2104463631 hasConceptScore W2104463631C2778690821 @default.
• W2104463631 hasConceptScore W2104463631C2778723905 @default.
• W2104463631 hasConceptScore W2104463631C2778754761 @default.
• W2104463631 hasConceptScore W2104463631C547475151 @default.
• W2104463631 hasConceptScore W2104463631C55493867 @default.
• W2104463631 hasConceptScore W2104463631C60987743 @default.
• W2104463631 hasConceptScore W2104463631C86803240 @default.
• W2104463631 hasConceptScore W2104463631C89423630 @default.

• next