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• W2104466920 abstract "Skeletal muscle differentiation is a multistep, complex pathway in which several important signaling molecules are involved. Recently, microRNAs (miRNAs), endogenous non-coding small RNAs that regulate mRNAs, have been proposed to be involved in skeletal muscle differentiation. In this study, we identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profiles between C2C12 cells and Wnt4 over-expressing C2C12 cells (W4-08), which can spontaneously differentiate into myotubes.We identified miR-206, miR-133a, and miR-133b as up-regulated miRNAs and miR-487b, miR-3963 and miR-6412 as down-regulated miRNAs in differentiating cells. We focused on the down-regulated miRNAs because their functions were largely unknown. Transfection of mimics of these miRNAs into C2C12 cells resulted in significantly reduced expression of myogenic differentiation markers, including troponin T and myosin heavy chain fast type and slow type, but did not affect the expression of the myogenic transcription factors, MyoD and myogenin.These miRNAs were characterized as new myogenic differentiation-associated miRNAs which may delay late myogenic differentiation or maturation." @default.
• W2104466920 created "2016-06-24" @default.
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• W2104466920 date "2015-04-30" @default.
• W2104466920 modified "2023-09-25" @default.
• W2104466920 title "miR-487b, miR-3963 and miR-6412 delay myogenic differentiation in mouse myoblast-derived C2C12 cells" @default.
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• W2104466920 doi "https://doi.org/10.1186/s12860-015-0061-9" @default.
• W2104466920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4830013" @default.
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• W2104466920 hasPublicationYear "2015" @default.
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