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• W2104468114 abstract "During intra-erythrocytic development, late asexually replicating Plasmodium falciparum parasites sequester from peripheral circulation. This facilitates chronic infection and is linked to severe disease and organ-specific pathology including cerebral and placental malaria. Immature gametocytes - sexual stage precursor cells - likewise disappear from circulation. Recent work has demonstrated that these sexual stage parasites are located in the hematopoietic system of the bone marrow before mature gametocytes are released into the bloodstream to facilitate mosquito transmission. However, as sequestration occurs only in vivo and not during in vitro culture, the mechanisms by which it is regulated and enacted (particularly by the gametocyte stage) remain poorly understood.We generated the most comprehensive P. falciparum functional gene network to date by integrating global transcriptional data from a large set of asexual and sexual in vitro samples, patient-derived in vivo samples, and a new set of in vitro samples profiling sexual commitment. We defined more than 250 functional modules (clusters) of genes that are co-expressed primarily during the intra-erythrocytic parasite cycle, including 35 during sexual commitment and gametocyte development. Comparing the in vivo and in vitro datasets allowed us, for the first time, to map the time point of asexual parasite sequestration in patients to 22 hours post-invasion, confirming previous in vitro observations on the dynamics of host cell modification and cytoadherence. Moreover, we were able to define the properties of gametocyte sequestration, demonstrating the presence of two circulating gametocyte populations: gametocyte rings between 0 and approximately 30 hours post-invasion and mature gametocytes after around 7 days post-invasion.This study provides a bioinformatics resource for the functional elucidation of parasite life cycle dynamics and specifically demonstrates the presence of the gametocyte ring stages in circulation, adding significantly to our understanding of the dynamics of gametocyte sequestration in vivo." @default.
• W2104468114 created "2016-06-24" @default.
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• W2104468114 date "2015-01-01" @default.
• W2104468114 modified "2023-10-01" @default.
• W2104468114 title "Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection" @default.
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• W2104468114 cites W1973541716 @default.
• W2104468114 cites W1974091218 @default.
• W2104468114 cites W1975806731 @default.
• W2104468114 cites W1977859620 @default.
• W2104468114 cites W1978455510 @default.
• W2104468114 cites W1983724086 @default.
• W2104468114 cites W1985395426 @default.
• W2104468114 cites W1987113620 @default.
• W2104468114 cites W2011941308 @default.
• W2104468114 cites W2012614126 @default.
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• W2104468114 cites W2017732305 @default.
• W2104468114 cites W2020251171 @default.
• W2104468114 cites W2021868082 @default.
• W2104468114 cites W2024169795 @default.
• W2104468114 cites W2035888977 @default.
• W2104468114 cites W2039227742 @default.
• W2104468114 cites W2043354088 @default.
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• W2104468114 cites W2053758185 @default.
• W2104468114 cites W2062155016 @default.
• W2104468114 cites W2074689898 @default.
• W2104468114 cites W2078096892 @default.
• W2104468114 cites W2083788953 @default.
• W2104468114 cites W2090613637 @default.
• W2104468114 cites W2094132647 @default.
• W2104468114 cites W2094381221 @default.
• W2104468114 cites W2095956310 @default.
• W2104468114 cites W2096083625 @default.
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• W2104468114 cites W2126071146 @default.
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• W2104468114 doi "https://doi.org/10.1186/s13073-015-0133-7" @default.
• W2104468114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4342211" @default.
• W2104468114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25722744" @default.
• W2104468114 hasPublicationYear "2015" @default.
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