FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104473080> ?p ?o ?g. }

• W2104473080 endingPage "41685" @default.
• W2104473080 startingPage "41675" @default.
• W2104473080 abstract "γ-Protocadherins (PCDH-γ) regulate neuronal survival in the vertebrate central nervous system. The molecular mechanisms of how PCDH-γ mediates this function are still not understood. In this study, we show that through their common cytoplasmic domain, different PCDH-γ isoforms interact with an intracellular adaptor protein named PDCD10 (programmed cell death 10). PDCD10 is also known as CCM3, a causative genetic defect for cerebral cavernous malformations in humans. Using RNAi-mediated knockdown, we demonstrate that PDCD10 is required for the occurrence of apoptosis upon PCDH-γ depletion in developing chicken spinal neurons. Moreover, overexpression of PDCD10 is sufficient to induce neuronal apoptosis. Taken together, our data reveal a novel function for PDCD10/CCM3, acting as a critical regulator of neuronal survival during development. γ-Protocadherins (PCDH-γ) regulate neuronal survival in the vertebrate central nervous system. The molecular mechanisms of how PCDH-γ mediates this function are still not understood. In this study, we show that through their common cytoplasmic domain, different PCDH-γ isoforms interact with an intracellular adaptor protein named PDCD10 (programmed cell death 10). PDCD10 is also known as CCM3, a causative genetic defect for cerebral cavernous malformations in humans. Using RNAi-mediated knockdown, we demonstrate that PDCD10 is required for the occurrence of apoptosis upon PCDH-γ depletion in developing chicken spinal neurons. Moreover, overexpression of PDCD10 is sufficient to induce neuronal apoptosis. Taken together, our data reveal a novel function for PDCD10/CCM3, acting as a critical regulator of neuronal survival during development." @default.
• W2104473080 created "2016-06-24" @default.
• W2104473080 creator A5009064402 @default.
• W2104473080 creator A5010381174 @default.
• W2104473080 creator A5015406510 @default.
• W2104473080 creator A5038295363 @default.
• W2104473080 date "2010-12-01" @default.
• W2104473080 modified "2023-10-18" @default.
• W2104473080 title "PDCD10/CCM3 Acts Downstream of γ-Protocadherins to Regulate Neuronal Survival" @default.
• W2104473080 cites W133424498 @default.
• W2104473080 cites W1583045777 @default.
• W2104473080 cites W1608253138 @default.
• W2104473080 cites W1758816958 @default.
• W2104473080 cites W1872191299 @default.
• W2104473080 cites W1896836582 @default.
• W2104473080 cites W1945370105 @default.
• W2104473080 cites W1968544851 @default.
• W2104473080 cites W1971430964 @default.
• W2104473080 cites W1974226533 @default.
• W2104473080 cites W1974594271 @default.
• W2104473080 cites W1975261862 @default.
• W2104473080 cites W1975559069 @default.
• W2104473080 cites W1976385326 @default.
• W2104473080 cites W1988120710 @default.
• W2104473080 cites W1990545433 @default.
• W2104473080 cites W2001949196 @default.
• W2104473080 cites W2006376420 @default.
• W2104473080 cites W2008535550 @default.
• W2104473080 cites W2018210971 @default.
• W2104473080 cites W2020869819 @default.
• W2104473080 cites W2027052842 @default.
• W2104473080 cites W2028725260 @default.
• W2104473080 cites W2028807389 @default.
• W2104473080 cites W2031259230 @default.
• W2104473080 cites W2032698079 @default.
• W2104473080 cites W2038587881 @default.
• W2104473080 cites W2039294916 @default.
• W2104473080 cites W2043451478 @default.
• W2104473080 cites W2047433704 @default.
• W2104473080 cites W2052385316 @default.
• W2104473080 cites W2054865251 @default.
• W2104473080 cites W2057187384 @default.
• W2104473080 cites W2060876619 @default.
• W2104473080 cites W2061095568 @default.
• W2104473080 cites W2066031882 @default.
• W2104473080 cites W2067450415 @default.
• W2104473080 cites W2069031661 @default.
• W2104473080 cites W2069638671 @default.
• W2104473080 cites W2070372326 @default.
• W2104473080 cites W2075361499 @default.
• W2104473080 cites W2076766254 @default.
• W2104473080 cites W2081237481 @default.
• W2104473080 cites W2084546503 @default.
• W2104473080 cites W2088373022 @default.
• W2104473080 cites W2088454405 @default.
• W2104473080 cites W2092449569 @default.
• W2104473080 cites W2099043491 @default.
• W2104473080 cites W2105879641 @default.
• W2104473080 cites W2106272768 @default.
• W2104473080 cites W2110233724 @default.
• W2104473080 cites W2111175144 @default.
• W2104473080 cites W2112800219 @default.
• W2104473080 cites W2112912820 @default.
• W2104473080 cites W2121802881 @default.
• W2104473080 cites W2121850322 @default.
• W2104473080 cites W2122244785 @default.
• W2104473080 cites W2128232666 @default.
• W2104473080 cites W2128891183 @default.
• W2104473080 cites W2134678910 @default.
• W2104473080 cites W2140608779 @default.
• W2104473080 cites W2142848667 @default.
• W2104473080 cites W2152970852 @default.
• W2104473080 cites W2154352037 @default.
• W2104473080 cites W2154745705 @default.
• W2104473080 cites W2155899899 @default.
• W2104473080 cites W2169030822 @default.
• W2104473080 cites W2169550012 @default.
• W2104473080 cites W2171100408 @default.
• W2104473080 doi "https://doi.org/10.1074/jbc.m110.179895" @default.
• W2104473080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3009895" @default.
• W2104473080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21041308" @default.
• W2104473080 hasPublicationYear "2010" @default.
• W2104473080 type Work @default.
• W2104473080 sameAs 2104473080 @default.
• W2104473080 citedByCount "32" @default.
• W2104473080 countsByYear W21044730802012 @default.
• W2104473080 countsByYear W21044730802013 @default.
• W2104473080 countsByYear W21044730802014 @default.
• W2104473080 countsByYear W21044730802015 @default.
• W2104473080 countsByYear W21044730802016 @default.
• W2104473080 countsByYear W21044730802017 @default.
• W2104473080 countsByYear W21044730802018 @default.
• W2104473080 countsByYear W21044730802019 @default.
• W2104473080 countsByYear W21044730802020 @default.
• W2104473080 countsByYear W21044730802021 @default.
• W2104473080 countsByYear W21044730802022 @default.
• W2104473080 countsByYear W21044730802023 @default.
• W2104473080 crossrefType "journal-article" @default.

• next