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• W2104476402 startingPage "H1471" @default.
• W2104476402 abstract "The possible involvement of different kinases in the α 1 -adrenoreceptor (AR)-mediated positive inotropic effect (PIE) was investigated in rat papillary muscle and compared with β-AR-, endothelin receptor- and phorbol ester-induced changes in contractility. The α 1 -AR-induced PIE was not reduced by the inhibitors of protein kinase C (PKC), MAPK (ERK and p38), phosphatidyl inositol 3-kinase, or calmodulin kinase II. However, PKC inhibition attenuated the effect of phorbol 12-myristate 13-acetate (PMA) on contractility. α 1 -AR-induced PIE was reduced by ∼90% during inhibition of myosin light chain kinase (MLCK) by 1-(5-chloronaphthalene-1-sulfonyl)1 H-hexahydro-1,4-diazepine (ML-9). Endothelin-induced PIE was also reduced by ML-9, but ML-9 had no effect on β-AR-induced PIE. The Rho kinase inhibitor Y-27632 also reduced the α 1 -AR-induced PIE. The α 1 -AR-induced PIE in muscle strips from explanted failing human hearts was also sensitive to MLCK inhibition. α 1 -AR induced a modest increase in 32 P incorporation into myosin light chain in isolated rat cardiomyocytes. This effect was eliminated by ML-9. The PIE of α 1 -AR stimulation seems to be dependent on MLCK phosphorylation." @default.
• W2104476402 created "2016-06-24" @default.
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• W2104476402 date "2002-10-01" @default.
• W2104476402 modified "2023-09-26" @default.
• W2104476402 title "α₁-AR-induced positive inotropic response in heart is dependent on myosin light chain phosphorylation" @default.
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• W2104476402 doi "https://doi.org/10.1152/ajpheart.00232.2002" @default.
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