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• W2104493166 abstract "MicroRNAs (miRNA) play critical roles in human development and disease. As such, the targeting of miRNAs is considered attractive as a novel therapeutic strategy. A major bottleneck toward this goal, however, has been the identification of small molecule probes that are specific for select RNAs and methods that will facilitate such discovery efforts. Using pre-microRNAs as proof-of-concept, herein we report a conceptually new and innovative approach for assaying RNA–small molecule interactions. Through this platform assay technology, which we term catalytic enzyme-linked click chemistry assay or cat-ELCCA, we have designed a method that can be implemented in high throughput, is virtually free of false readouts, and is general for all nucleic acids. Through cat-ELCCA, we envision the discovery of selective small molecule ligands for disease-relevant miRNAs to promote the field of RNA-targeted drug discovery and further our understanding of the role of miRNAs in cellular biology." @default.
• W2104493166 created "2016-06-24" @default.
• W2104493166 creator A5009185654 @default.
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• W2104493166 date "2014-12-17" @default.
• W2104493166 modified "2023-09-26" @default.
• W2104493166 title "High-Throughput Platform Assay Technology for the Discovery of pre-microRNA-Selective Small Molecule Probes" @default.
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• W2104493166 doi "https://doi.org/10.1021/bc500544v" @default.
• W2104493166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25506628" @default.
• W2104493166 hasPublicationYear "2014" @default.
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