FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104516575> ?p ?o ?g. }

• W2104516575 endingPage "834" @default.
• W2104516575 startingPage "824" @default.
• W2104516575 abstract "Vascular calcification is a frequent cause of morbidity and mortality in patients with CKD and the general population. The common association between vascular calcification and osteoporosis suggests a link between bone and vascular disorders. Because microRNAs (miRs) are involved in the transdifferentiation of vascular smooth muscle cells into osteoblast-like cells, we investigated whether miRs implicated in osteoblast differentiation and bone formation are involved in vascular calcification. Different levels of uremia, hyperphosphatemia, and aortic calcification were induced by feeding nephrectomized rats a normal or high-phosphorus diet for 12 or 20 weeks, at which times the levels of eight miRs (miR-29b, miR-125, miR-133b, miR-135, miR-141, miR-200a, miR-204, and miR-211) in the aorta were analyzed. Compared with controls and uremic rats fed a normal diet, uremic rats fed a high-phosphorous diet had lower levels of miR-133b and miR-211 and higher levels of miR-29b that correlated respectively with greater expression of osteogenic RUNX2 and with lower expression of several inhibitors of osteoblastic differentiation. Uremia per se mildly reduced miR-133b levels only. Similar results were obtained in two in vitro models of vascular calcification (uremic serum and high–calcium and –phosphorus medium), and experiments using antagomirs and mimics to modify miR-29b, miR-133b, and miR-211 expression levels in these models confirmed that these miRs regulate the calcification process. We conclude that miR-29b, miR-133b, and miR-211 have direct roles in the vascular smooth muscle calcification induced by high phosphorus and may be new therapeutic targets in the management of vascular calcification." @default.
• W2104516575 created "2016-06-24" @default.
• W2104516575 creator A5008849914 @default.
• W2104516575 creator A5018727402 @default.
• W2104516575 creator A5020844169 @default.
• W2104516575 creator A5040434561 @default.
• W2104516575 creator A5043363248 @default.
• W2104516575 creator A5057833421 @default.
• W2104516575 creator A5073028441 @default.
• W2104516575 creator A5091624171 @default.
• W2104516575 date "2016-03-01" @default.
• W2104516575 modified "2023-10-03" @default.
• W2104516575 title "MicroRNAs 29b, 133b, and 211 Regulate Vascular Smooth Muscle Calcification Mediated by High Phosphorus" @default.
• W2104516575 cites W144423133 @default.
• W2104516575 cites W1859344324 @default.
• W2104516575 cites W1970468800 @default.
• W2104516575 cites W1975151676 @default.
• W2104516575 cites W1978456616 @default.
• W2104516575 cites W1979517335 @default.
• W2104516575 cites W1989479329 @default.
• W2104516575 cites W1991226023 @default.
• W2104516575 cites W1997812904 @default.
• W2104516575 cites W2000782553 @default.
• W2104516575 cites W2013009411 @default.
• W2104516575 cites W2017173759 @default.
• W2104516575 cites W2017435031 @default.
• W2104516575 cites W2024941123 @default.
• W2104516575 cites W2027138842 @default.
• W2104516575 cites W2028928108 @default.
• W2104516575 cites W2032637659 @default.
• W2104516575 cites W2038622868 @default.
• W2104516575 cites W2039068212 @default.
• W2104516575 cites W2039437429 @default.
• W2104516575 cites W2042336965 @default.
• W2104516575 cites W2042988034 @default.
• W2104516575 cites W2066746047 @default.
• W2104516575 cites W2081134904 @default.
• W2104516575 cites W2086664586 @default.
• W2104516575 cites W2086905000 @default.
• W2104516575 cites W2096253076 @default.
• W2104516575 cites W2107277218 @default.
• W2104516575 cites W2114439420 @default.
• W2104516575 cites W2122455142 @default.
• W2104516575 cites W2123740493 @default.
• W2104516575 cites W2128551532 @default.
• W2104516575 cites W2133656012 @default.
• W2104516575 cites W2137602565 @default.
• W2104516575 cites W2139581682 @default.
• W2104516575 cites W2141499934 @default.
• W2104516575 cites W2149476024 @default.
• W2104516575 cites W2151434420 @default.
• W2104516575 cites W2161762684 @default.
• W2104516575 cites W2163087966 @default.
• W2104516575 cites W2170893247 @default.
• W2104516575 cites W2192080449 @default.
• W2104516575 cites W2548599454 @default.
• W2104516575 cites W2699220065 @default.
• W2104516575 doi "https://doi.org/10.1681/asn.2014050520" @default.
• W2104516575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4769184" @default.
• W2104516575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26187577" @default.
• W2104516575 hasPublicationYear "2016" @default.
• W2104516575 type Work @default.
• W2104516575 sameAs 2104516575 @default.
• W2104516575 citedByCount "63" @default.
• W2104516575 countsByYear W21045165752015 @default.
• W2104516575 countsByYear W21045165752016 @default.
• W2104516575 countsByYear W21045165752017 @default.
• W2104516575 countsByYear W21045165752018 @default.
• W2104516575 countsByYear W21045165752019 @default.
• W2104516575 countsByYear W21045165752020 @default.
• W2104516575 countsByYear W21045165752021 @default.
• W2104516575 countsByYear W21045165752022 @default.
• W2104516575 countsByYear W21045165752023 @default.
• W2104516575 crossrefType "journal-article" @default.
• W2104516575 hasAuthorship W2104516575A5008849914 @default.
• W2104516575 hasAuthorship W2104516575A5018727402 @default.
• W2104516575 hasAuthorship W2104516575A5020844169 @default.
• W2104516575 hasAuthorship W2104516575A5040434561 @default.
• W2104516575 hasAuthorship W2104516575A5043363248 @default.
• W2104516575 hasAuthorship W2104516575A5057833421 @default.
• W2104516575 hasAuthorship W2104516575A5073028441 @default.
• W2104516575 hasAuthorship W2104516575A5091624171 @default.
• W2104516575 hasBestOaLocation W21045165751 @default.
• W2104516575 hasConcept C104317684 @default.
• W2104516575 hasConcept C126322002 @default.
• W2104516575 hasConcept C134018914 @default.
• W2104516575 hasConcept C145059251 @default.
• W2104516575 hasConcept C185592680 @default.
• W2104516575 hasConcept C202751555 @default.
• W2104516575 hasConcept C2776036575 @default.
• W2104516575 hasConcept C2776363554 @default.
• W2104516575 hasConcept C2776635150 @default.
• W2104516575 hasConcept C2778260815 @default.
• W2104516575 hasConcept C2779395532 @default.
• W2104516575 hasConcept C2780309369 @default.
• W2104516575 hasConcept C2780804394 @default.
• W2104516575 hasConcept C2908647359 @default.
• W2104516575 hasConcept C2992686903 @default.

• next