FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104521778> ?p ?o ?g. }

• W2104521778 endingPage "969" @default.
• W2104521778 startingPage "963" @default.
• W2104521778 abstract "We sought to evaluate the contractile proteins in cardiomyocytes of patients with end-stage heart failure (HF) before and after mechanical support with a left ventricular assist device (LVAD).Improvement of myocyte dysfunction has been suggested after LVAD support.Fourteen patients' myocardial biopsies taken at the time of LVAD implantation and after explantation, at the time of heart transplantation, were processed for routine hematoxylin-eosin staining and immunohistochemistry using monoclonal antibodies against actin, myosin, tropomyosin, troponin C and T and titin. A grading scale from 1 (abnormal staining of all myocytes, no cross-striation) to 5 (normal fiber anatomy and striation) was used. The cross-sectional area of cardiomyocytes was also measured.The cardiomyocytes' cross-sectional area decreased after support, from 519 +/- 94 microm(2) to 319 +/- 53 microm(2) (p < 0.001). Actin, tropomyosin, troponin C, troponin T and titin at the time of LVAD implantation showed widespread distortion of architecture; their grades were 1.4 +/- 0.6, 2.3 +/- 1.0, 2.1 +/- 0.9, 2.1 +/- 1.2 and 2.0 +/- 0.6, respectively. In contrast, myosin morphology was preserved (4.6 +/- 0.7). After LVAD support, actin, tropomyosin, troponin C, troponin T and titin showed improvement (grades 2.7 +/- 1.3 [p = 0.004], 3.2 +/- 1.2 [p = 0.021], 3.3 +/- 0.9 [p = 0.004], 3.0 +/- 1.1 [p = 0.048] and 3.1 +/- 0.9 [p = 0.001], respectively), but no normalization. The myosin pattern deteriorated slightly (3.6 +/- 1.6 [p = 0.058]).After LVAD support, during a period of 213 +/- 135 days in patients with end-stage HF, despite a decrease in the size of the cardiomyocytes, severe structural myocyte damage persisted. This does not support complete recovery of myocyte histologic features." @default.
• W2104521778 created "2016-06-24" @default.
• W2104521778 creator A5032942149 @default.
• W2104521778 creator A5040972846 @default.
• W2104521778 creator A5071116527 @default.
• W2104521778 creator A5071607731 @default.
• W2104521778 creator A5075731048 @default.
• W2104521778 creator A5081586342 @default.
• W2104521778 creator A5090128680 @default.
• W2104521778 date "2002-03-01" @default.
• W2104521778 modified "2023-10-17" @default.
• W2104521778 title "Left ventricular assist device in end-stage heart failure: persistence of structural myocyte damage after unloading" @default.
• W2104521778 cites W1525707088 @default.
• W2104521778 cites W1964283249 @default.
• W2104521778 cites W1968956483 @default.
• W2104521778 cites W1970031998 @default.
• W2104521778 cites W1972390595 @default.
• W2104521778 cites W1972860791 @default.
• W2104521778 cites W1992540995 @default.
• W2104521778 cites W2003733359 @default.
• W2104521778 cites W2004923301 @default.
• W2104521778 cites W2022940081 @default.
• W2104521778 cites W2030412225 @default.
• W2104521778 cites W2030920504 @default.
• W2104521778 cites W2031369770 @default.
• W2104521778 cites W2032822213 @default.
• W2104521778 cites W2039660780 @default.
• W2104521778 cites W2048184684 @default.
• W2104521778 cites W2049422477 @default.
• W2104521778 cites W2049443869 @default.
• W2104521778 cites W2050839858 @default.
• W2104521778 cites W2056804173 @default.
• W2104521778 cites W2058647883 @default.
• W2104521778 cites W2065756510 @default.
• W2104521778 cites W2066020583 @default.
• W2104521778 cites W2073873067 @default.
• W2104521778 cites W2078904330 @default.
• W2104521778 cites W2091349813 @default.
• W2104521778 cites W2093149476 @default.
• W2104521778 cites W2098644652 @default.
• W2104521778 cites W2107425890 @default.
• W2104521778 cites W2115607473 @default.
• W2104521778 cites W2138080145 @default.
• W2104521778 cites W2140709961 @default.
• W2104521778 cites W2157460773 @default.
• W2104521778 cites W2163098898 @default.
• W2104521778 cites W2165336496 @default.
• W2104521778 cites W2172010440 @default.
• W2104521778 cites W2394632822 @default.
• W2104521778 doi "https://doi.org/10.1016/s0735-1097(02)01713-8" @default.
• W2104521778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11897437" @default.
• W2104521778 hasPublicationYear "2002" @default.
• W2104521778 type Work @default.
• W2104521778 sameAs 2104521778 @default.
• W2104521778 citedByCount "73" @default.
• W2104521778 countsByYear W21045217782012 @default.
• W2104521778 countsByYear W21045217782013 @default.
• W2104521778 countsByYear W21045217782014 @default.
• W2104521778 countsByYear W21045217782015 @default.
• W2104521778 countsByYear W21045217782017 @default.
• W2104521778 countsByYear W21045217782018 @default.
• W2104521778 countsByYear W21045217782019 @default.
• W2104521778 countsByYear W21045217782020 @default.
• W2104521778 countsByYear W21045217782021 @default.
• W2104521778 countsByYear W21045217782022 @default.
• W2104521778 countsByYear W21045217782023 @default.
• W2104521778 crossrefType "journal-article" @default.
• W2104521778 hasAuthorship W2104521778A5032942149 @default.
• W2104521778 hasAuthorship W2104521778A5040972846 @default.
• W2104521778 hasAuthorship W2104521778A5071116527 @default.
• W2104521778 hasAuthorship W2104521778A5071607731 @default.
• W2104521778 hasAuthorship W2104521778A5075731048 @default.
• W2104521778 hasAuthorship W2104521778A5081586342 @default.
• W2104521778 hasAuthorship W2104521778A5090128680 @default.
• W2104521778 hasBestOaLocation W21045217781 @default.
• W2104521778 hasConcept C115725540 @default.
• W2104521778 hasConcept C125473707 @default.
• W2104521778 hasConcept C12554922 @default.
• W2104521778 hasConcept C125705527 @default.
• W2104521778 hasConcept C126322002 @default.
• W2104521778 hasConcept C144469398 @default.
• W2104521778 hasConcept C164705383 @default.
• W2104521778 hasConcept C204232928 @default.
• W2104521778 hasConcept C207200792 @default.
• W2104521778 hasConcept C2778198053 @default.
• W2104521778 hasConcept C2778774980 @default.
• W2104521778 hasConcept C36036425 @default.
• W2104521778 hasConcept C39133596 @default.
• W2104521778 hasConcept C500558357 @default.
• W2104521778 hasConcept C68731436 @default.
• W2104521778 hasConcept C6997183 @default.
• W2104521778 hasConcept C71924100 @default.
• W2104521778 hasConcept C7301908 @default.
• W2104521778 hasConcept C86803240 @default.
• W2104521778 hasConcept C8880881 @default.
• W2104521778 hasConcept C90671521 @default.
• W2104521778 hasConcept C95444343 @default.
• W2104521778 hasConceptScore W2104521778C115725540 @default.

• next