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- W2104537018 abstract "✓ To test the hypothesis that concussive brain injury impairs autoregulation of cerebral blood flow (CBF), 24 cats were subjected to hemorrhagic hypotension in 10-mm Hg increments while measurements were made of arterial and intracranial pressure, CBF, and arterial blood gases. Eight cats served as controls, while eight were subjected to mild fluid percussion injury of the brain (1.5 to 2.2 atmospheres) and eight to severe injury (2.8 to 4.8 atmospheres). Injury produced only transient changes in arterial and intracranial pressure, and no change in resting CBF. Impairment of autoregulation was found in injured animals, more pronounced in the severe-injury group. This could not be explained on the basis of intracranial hypertension, hypoxemia, hypercarbia, or brain damage localized to the area of the blood flow electrodes. It is, therefore, concluded that concussive brain injury produces a generalized loss of autoregulation for at least several hours following injury." @default.
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- W2104537018 date "1980-10-01" @default.
- W2104537018 modified "2023-10-10" @default.
- W2104537018 title "Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain" @default.
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- W2104537018 doi "https://doi.org/10.3171/jns.1980.53.4.0500" @default.
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