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• W2104540904 abstract "Although it has long been known that human CD4(+) T cells can express functional class II MHC molecules, the role of lysosomal proteases in the T cell class II MHC processing and presentation pathway is unknown. Using CD4(+) T cell clones that constitutively express class II MHC, we determined that cathepsin S is necessary for invariant chain proteolysis in T cells. CD4(+)HLA-DR(+) T cells down-regulated cathepsin S expression and activity 18 h after activation, thereby ceasing nascent class II MHC product formation. This blockade resulted in the loss of the invariant chain fragment CLIP from the cell surface, suggesting that-like professional APC-CD4(+) HLA-DR(+) cells modulate self-Ag presentation as a consequence of activation. Furthermore, cathepsin S expression and activity, and concordantly cell surface CLIP expression, was reduced in HLA-DR(+) CD4(+) T cells as compared with B cells both in vitro and ex vivo." @default.
• W2104540904 created "2016-06-24" @default.
• W2104540904 creator A5004216670 @default.
• W2104540904 creator A5004313141 @default.
• W2104540904 creator A5081514135 @default.
• W2104540904 date "2009-07-15" @default.
• W2104540904 modified "2023-10-10" @default.
• W2104540904 title "Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells" @default.
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• W2104540904 doi "https://doi.org/10.4049/jimmunol.0900921" @default.
• W2104540904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2752291" @default.
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• W2104540904 hasPublicationYear "2009" @default.
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